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Devilstongue gulcomannan hemostatic sponge and preparation method thereof

A technology of konjac glucomannan and hemostatic sponge, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of uneven pore size, poor color and rough konjac sponge, etc., and achieve uniform pore size, good flexibility, and air permeability. The effect of high rate and water absorption

Active Publication Date: 2015-01-07
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patent application whose publication number is CN102389584A discloses a kind of konjac sponge medical dressing that adopts konjac powder as a raw material. The obtained konjac sponge is rough, hard, poor in color and uneven in pore size

Method used

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  • Devilstongue gulcomannan hemostatic sponge and preparation method thereof
  • Devilstongue gulcomannan hemostatic sponge and preparation method thereof
  • Devilstongue gulcomannan hemostatic sponge and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0014] formula:

[0015]

[0016] Preparation process: Weigh konjac powder, add it to deionized water, heat at 40°C, dissolve and expand for 30 minutes, stir until the colloid is smooth and fine, then add sodium bicarbonate to dissolve, add Tween 80 and glycerin while it is hot, and stir to produce uniform Fine foam, then add 60% ethanol to solidify, transfer the resulting solution to a mold, control the thickness of 1mm, pre-freeze at -20°C for 24 hours, then vacuum dry for 24 hours, cut, pack, Co 60 Sterilize by irradiation to obtain konjac glucomannan hemostatic sponge.

Embodiment 2

[0018] formula:

[0019]

[0020] Preparation process: Weigh konjac powder, add it to deionized water, heat at 45°C, dissolve and expand for 35 minutes, stir until the colloid is smooth and fine, then add sodium bicarbonate to dissolve, add Tween 80 and glycerin while it is hot, and stir to produce uniform Fine foam, then add 60% ethanol to solidify, transfer the resulting solution to a mold, control the thickness of 2mm, pre-freeze at -20°C for 24 hours, then vacuum dry for 30 hours, cut, pack, Co 60 Sterilize by irradiation to obtain konjac glucomannan hemostatic sponge.

Embodiment 3

[0022] formula:

[0023]

[0024] Preparation process: Weigh konjac powder, add it to deionized water, heat at 50°C, dissolve and expand for 40 minutes, stir until the colloid is smooth and fine, then add sodium bicarbonate to dissolve, add Tween 80 and glycerin while it is hot, and stir to produce uniform Fine foam, then add 60% ethanol to solidify, transfer the resulting solution to a mold, control the thickness of 3mm, pre-freeze at -20°C for 24 hours, then vacuum dry for 36 hours, cut, pack, Co 60 Sterilize by irradiation to obtain konjac glucomannan hemostatic sponge.

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Abstract

The invention discloses a devilstongue gulcomannan hemostatic sponge. The devilstongue gulcomannan hemostatic sponge comprises 2-4g of devilstongue fine powder, 1-3g of sodium bicarbonate, 0.2-0.6mL of Tween 80, 0.6mL of glycerinum, 8-12mL of ethyl alcohol with volume fraction being 60%, and 100g of water. According to the devilstongue gulcomannan hemostatic sponge, the devilstongue fine powder containing high-purity gulcomannan (>90%) serves as raw materials, gel with even froth is prepared by regulating the amount of the sodium bicarbonate, the amount of the Tween 80 and the amount of the glycerinum, and then the thickness of gel solution in a grinding tool, the pre-freezing temperature and time and time of vacuum freeze and drying are controlled to prepare the devilstongue gulcomannan hemostatic sponge which is good in flexibility, even in pore diameter and high in air permeability and water absorption. The prepared devilstongue gulcomannan hemostatic sponge has water-absorbing quality, can not be dissolved in water, and can not be cracked after being seriously rubbed. When the devilstongue gulcomannan hemostatic sponge is immerged in water at the temperature of 20 DEG C, the amount of water absorbed by the sponge is 25 times larger than the weight of a sample.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a medical hemostatic sponge degradable in vivo and a preparation method thereof. Background technique [0002] The mechanism of action of the hemostatic sponge is that the hydrophilic polymer material that makes up the sponge has collagen-like properties. When it is applied to a damaged blood vessel, the platelets will adhere and coagulate when they encounter collagen, and then form a platelet thrombus, and then coagulate. Fibrin embolism blocks the damaged part of the blood vessel to achieve hemostasis; in addition, it also stops bleeding due to external pressure and mechanical blockage of the sponge. Commonly used auxiliary materials for hemostatic sponges are gelatin, starch, etc. With the continuous development of pharmaceutical polymer materials, more and more hydrophilic colloid materials are used in clinical experiments. For example, the Chinese patent ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44C08J9/08C08L5/02C08K5/053
Inventor 罗永煌姜草罗雷王翠园王帅谭明国龙飞曾海春骆晓宏
Owner SOUTHWEST UNIV