Clindamycin hydrochloride preparation for injection and preparation method thereof

A technology for clindamycin hydrochloride and injections, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problem of no relative drug advantage and inability to effectively control drug release Speed, adverse drug reactions and other issues, to achieve the effect of reducing the occurrence of adverse reactions, improving bioavailability, and maintaining pharmacological activity
CN103432087BActive Publication Date: 2015-02-18WUHAN PUSHENG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN PUSHENG PHARMA
Publication Date
2015-02-18

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Abstract

The invention discloses a clindamycin hydrochloride preparation for injection and a preparation method thereof. The preparation is prepared from clindamycin hydrochloride and auxiliary materials such as Fe3O4 magnetic powder and carboxymethyl glucose. In the preparation process, Fe3O4 magnetic powder and carboxymethyl glucose mixed are stable in property to easily form microballoons with certain strength and can be fully encapsulated or the medicine completely enters into a carrier framework, relatively. After injection, the medicine can be reasonably released in human body, so that the pharmacological activity of the medicine is maintained and the bioavailability of the medicine is improved. Meanwhile, the time of deliveries of medicines to be used for a long time can be reduced due to the sustained-release preparation, so that balance of blood concentration can be maintained, the peak valley phenomenon is avoided, and untoward effects of the medicine are reduced. In addition, the iron content of the carrier in the preparation does not affect normal total iron supplementing amount of the patient, and magnetic particles can be safely discharged outside the human body through normal excretion of the human body.
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Description

technical field

[0001] The invention belongs to a pharmaceutical preparation, in particular to a clindamycin hydrochloride preparation for injection and a preparation method thereof. Background technique

[0002] Clindamycin Hydrochloride (Clindamycin Hydrochloride) chemical name 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7(S)-chloro-6, 7,8-trideoxy-L-threo-α-D-galactosoctopyranoside hydrochloride is a derivative obtained after the hydroxyl group at the 7-position of lincomycin is replaced by chlorine, which belongs to antibiotic drugs. Synthesized by Magerlein et al. in 1966, its antibacterial activity is 4-8 times stronger than that of lincomycin. Clindamycin hydrochloride has antibacterial activity against gram-positive aerobic bacteria, streptococcus and staphylococcus, and also has antibacterial activity against various anaerobic bacteria, chlamydia, mycoplasma, plasmodium and toxoplasma. The 50s subunit of the ribosome inhibits the synthesis of bac...

Claims

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