Method for rapidly preparing forsythin from forsythia suspense leaves
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A technology for forsythia leaves and forsythin, which is applied in the field of rapidly preparing forsythin from forsythia leaves, can solve the problems of low purity, long time consumption, cumbersome methods and the like
Inactive Publication Date: 2013-12-18
SHANXI UNIV
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[0014] The purpose of the present invention is to overcome the problems of long time consumption, cumbersome methods and low purity in the prior art, and provide a method for preparing forsythin from forsythia leaves with simple method, high purity and fast
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Embodiment 1
[0031] 1) Take forsythia leaves, crush them, and pass through a 10-20 mesh sieve to obtain powder;
[0032] 2) Weigh 200g of forsythia leaf powder, add 2000mL of absolute ethanol to extract by back distillation, extract twice, filter with three layers of gauze, and obtain the filtrate;
[0033] 3) Concentrate the filtrate to a paste. Part of the paste was dried and detected by HPLC as figure 1 shown. Add 8 times the volume of distilled water to the rest of the paste, filter under reduced pressure on filter paper, and obtain the filtrate;
[0034] 4) Concentrate the filtrate obtained in step 3) to 40% of the original volume, refrigerate at 4°C for 8 hours, filter under reduced pressure on filter paper, and obtain a precipitate;
[0035] 5) Dissolve the precipitate with ethanol solution, add petroleum ether, the volume ratio of petroleum ether and ethanol is 1:1, mix well, stand for extraction for 8 hours, and obtain upper and lower layers of solution; figure 2 For the abso...
Embodiment 2
[0039] In step 2), absolute ethanol was back distilled and extracted 3 times, and the others were the same as in Example 1. 2.01 g of forsythin was obtained, and its purity was measured by HPLC, and the purity reached 98.4%.
Embodiment 3
[0041] In step 5), petroleum ether is added for extraction, the volume ratio of petroleum ether to ethanol is 0.5:1, and the others are the same as in Example 1. 1.97 g of forsythin was obtained, and its purity was measured by HPLC, and the purity reached 98.2%.
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Abstract
The invention provides a method for rapidly preparing forsythin from forsythia suspense leaves and aims at solving the problems that forsythin can be easily decomposed, a preparation process is tedious and long time is consumed in the prior art. The method for rapidly preparing the forsythin from the forsythia suspense leaves comprises the following steps: preparing forsythia suspense leaf powder, firstly carrying out reflux extracting for 2-3 times by adopting absolute ethyl alcohol, concentrating filtrate into paste, then dissolving by adopting distilled water and filtering, concentrating obtained filtrate, refrigerating, filtering to obtain precipitate, dissolving the precipitate by adopting an ethyl alcohol solution, adding petroleum ether for extracting, and concentrating, drying and recrystallizing a solution at the lower layer for 2-4 times, thus the forsythin is obtained. Purity of the obtained forsythin is more than 98% when being detected by virtue of HPLC (high performance liquid chromatography). By adopting the method for rapidly preparing the forsythin from the forsythia suspense leaves, impurities can be greatly reduced, and great convenience is provided for subsequent purification operation; the petroleum ether is adopted for extracting, so that interference of chlorophyll is eliminated, and the purify of the forsythin is greatly increased; no column chromatography is used during separation, so that consumed time is greatly shortened, and manpower and time are saved for production.
Description
technical field [0001] The invention relates to a method for extracting forsythin from forsythia leaves, in particular to a method for rapidly preparing forsythin from forsythia leaves. Background technique [0002] Forsythia suspensa (Thunb.) Vahl is a plant of the genus Forsythia in the family Oleaceae, and it is one of the traditional Chinese medicines commonly used in clinical practice. The first part of "Chinese Pharmacopoeia 2010" describes on page 159: Forsythia has the functions of clearing away heat and detoxification, reducing swelling and dispelling stagnation, and evacuating wind-heat. For carbuncle, scrofula, acute mastitis, erysipelas, wind-heat cold, febrile disease at the onset, warm heat enters the camp, high fever and polydipsia, dizziness and spotting, hot stranguria and astringent pain. Modern pharmacological research shows that Forsythia has antibacterial properties (Li Zhongxing et al. Tianjin Traditional Chinese Medicine. 2007, 24 (4): 328-331; Liu Sh...
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