Method for rapidly preparing forsythin from forsythia suspense leaves

Abstract

The invention provides a method for rapidly preparing forsythin from forsythia suspense leaves and aims at solving the problems that forsythin can be easily decomposed, a preparation process is tedious and long time is consumed in the prior art. The method for rapidly preparing the forsythin from the forsythia suspense leaves comprises the following steps: preparing forsythia suspense leaf powder, firstly carrying out reflux extracting for 2-3 times by adopting absolute ethyl alcohol, concentrating filtrate into paste, then dissolving by adopting distilled water and filtering, concentrating obtained filtrate, refrigerating, filtering to obtain precipitate, dissolving the precipitate by adopting an ethyl alcohol solution, adding petroleum ether for extracting, and concentrating, drying and recrystallizing a solution at the lower layer for 2-4 times, thus the forsythin is obtained. Purity of the obtained forsythin is more than 98% when being detected by virtue of HPLC (high performance liquid chromatography). By adopting the method for rapidly preparing the forsythin from the forsythia suspense leaves, impurities can be greatly reduced, and great convenience is provided for subsequent purification operation; the petroleum ether is adopted for extracting, so that interference of chlorophyll is eliminated, and the purify of the forsythin is greatly increased; no column chromatography is used during separation, so that consumed time is greatly shortened, and manpower and time are saved for production.

Description

technical field

[0001] The invention relates to a method for extracting forsythin from forsythia leaves, in particular to a method for rapidly preparing forsythin from forsythia leaves. Background technique

[0002] Forsythia suspensa (Thunb.) Vahl is a plant of the genus Forsythia in the family Oleaceae, and it is one of the traditional Chinese medicines commonly used in clinical practice. The first part of "Chinese Pharmacopoeia 2010" describes on page 159: Forsythia has the functions of clearing away heat and detoxification, reducing swelling and dispelling stagnation, and evacuating wind-heat. For carbuncle, scrofula, acute mastitis, erysipelas, wind-heat cold, febrile disease at the onset, warm heat enters the camp, high fever and polydipsia, dizziness and spotting, hot stranguria and astringent pain. Modern pharmacological research shows that Forsythia has antibacterial properties (Li Zhongxing et al. Tianjin Traditional Chinese Medicine. 2007, 24 (4): 328-331; Liu Sh...

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