Photoacoustic endoscope

An endoscope and laser technology, used in catheters, operations, etc., can solve the problems of low imaging resolution, low soft tissue contrast, and can not fully meet clinical needs, and achieve the effect of high image resolution and good optical resolution.

Active Publication Date: 2013-12-25
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The optical endoscope can only image the surface of the internal biological tissue through the CCD, and cannot observe the tissue below the epidermis, which limits its ability to diagnose diseases to a certain extent
New optical endoscopes, such as OCT endoscopes, can image the section of the digestive tract or coronary arteries through focused beams, and have high resolution, but because they can only be used without tissue scattering or only through a few Subscattered ballistic photon imaging has an imaging depth of only about 1 mm, which cannot fully meet clinical needs
More importantly, OCT endoscopes cannot directly distinguish between scattered photons and absorbed photons, so they cannot directly detect important physiological parameters such as blood oxygen content and oxygen metabolism that are closely related to light absorption with high sensitivity.
Ultrasonic endoscopy has a large penetration depth in tissue by using acoustics, and can image several centimeters deep tissue, but it has limitations such as low imaging resolution, low soft tissue contrast, and inability to reflect changes in physiological functions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Such as image 3 and Figure 4 As shown, an optical fiber 212 is disposed within a fiber optic guide 214 . Further, in this embodiment, the fiber optic guide 214 is provided with a flexible guide 216 . The optical fibers are wrapped in a flexible conduit 216 .

[0042] The endoscopic probe 220 includes an optical component and a fixing component (not shown in the figure). Wherein, the optical components include a self-focusing lens 221 and a reflector 222 . The fixing assembly includes a rigid conduit 224 with a photoacoustic window 223 at its free end and a plastic sleeve 225 inside the rigid conduit 224 .

[0043] Fiber optic conduit 214 is partially inserted into rigid conduit 224 . The outer wall of the fiber optic guide 214 inserted into the rigid guide 224 is socketed with the inner wall of the rigid guide 224 . The ends of the flexible conduit 216 and the optical fiber 212 are flush, and pass through the optical fiber conduit 214 , partly inserted into the ...

Embodiment 2

[0048] Such as Figure 5 As shown, the structure of the endoscopic probe and optical fiber of the present embodiment is similar to that of Embodiment 1, and the difference is that the rectangular prism 422 in the present embodiment is different from the reflector 222 of the isosceles rectangular prism used in Embodiment 1, Therefore, in this embodiment, without the adjustment member 228, it can be ensured that the ultrasonic transducer 426 can vertically receive the excited ultrasonic signal of the target tissue.

Embodiment 3

[0050] Such as Figure 6 As shown, an optical fiber 512 is disposed within a fiber optic guide 514 . Further, in this embodiment, a flexible conduit 516 is provided in the fiber optic conduit 514 . The optical fibers are wrapped in a flexible conduit 516 .

[0051] The endoscopic probe 520 includes an optical component and a fixing component (not shown in the figure). Wherein, the optical components include a self-focusing lens 521 and a reflector 522 . The fixing assembly includes a rigid conduit 524 with a photoacoustic window 523 at its free end and a plastic sleeve 525 inside the rigid conduit 524 .

[0052] The ends of the flexible conduit 516 and the optical fiber 512 are flush, and pass through the optical fiber conduit 514 , partly inserted into the plastic sleeve 525 , and coaxially connected with the self-focusing lens 521 at the end. The self-focusing lens 521 is wrapped in a plastic sleeve 525 and coaxially connected with the flexible conduit 516 and the optica...

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Abstract

The invention relates to a photoacoustic endoscope comprising a control system, a laser source, an optical path system, an endoscope probe, a probe scanning system, a data acquisition system, an image reconstruction system and a display system, wherein the photoacoustic endoscope tightly focuses lasers into a target tissue, detects ultrasonic signals generated after the lasers are absorbed by the target tissue, carries out the analysis process and images; the optical absorption characteristic of a biomass tissue is closely related with the change of physiological functions, so that the photoacoustic endoscope can more accurately react the image characteristic of the target tissue, has higher image resolution, contrast ratio and sensitivity, can effectively improve the resolution of the traditional photoacoustic endoscopic imaging by 10-100 times, and has better optical resolution effect.

Description

technical field [0001] The invention relates to the field of biomedical devices, in particular to a photoacoustic endoscope. Background technique [0002] Endoscopic imaging, as a non-invasive imaging method, is widely used in many fields of biomedicine and clinical diagnosis. Endoscopes effectively extend the human line of sight and can accurately observe the surface and / or internal features of biological tissues. [0003] Traditionally commonly used endoscopes mainly include optical and ultrasonic. The optical endoscope can only image the surface of the internal biological tissue through the CCD, and cannot observe the tissue conditions below the epidermis, which limits its ability to diagnose diseases to a certain extent. New optical endoscopes, such as OCT endoscopes, can image the section of the digestive tract or coronary arteries through focused beams, and have high resolution, but because they can only be used without tissue scattering or only through a few Subscat...

Claims

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Application Information

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IPC IPC(8): A61B8/12
Inventor 宋亮白晓淞
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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