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Preparation method for medical polymer material with blood compatibility

A technology of polymer materials and blood compatibility, applied in the field of surface modification of medical polymer materials, can solve the problems of unsuitable surface modification of polymer materials, achieve excellent blood compatibility, improve blood compatibility and biological Compatibility and structural stability

Active Publication Date: 2015-04-15
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the invention uses implanted N + Ions improve its blood compatibility, but it only treats pyrolytic carbon with good blood compatibility, and is not suitable for surface modification of other polymer materials with complex structures

Method used

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  • Preparation method for medical polymer material with blood compatibility
  • Preparation method for medical polymer material with blood compatibility
  • Preparation method for medical polymer material with blood compatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing a blood-compatible medical polymer material, comprising the following steps:

[0035] Place a medical polyethylene non-woven fabric with a thickness of 1.0mm and a size of 10.0cm×10.0cm on the sample stage in the ion implantation equipment, seal the vacuum chamber of the equipment, and evacuate to 2.5×10 -3 Pa, through argon, the pressure is maintained at 1.0×10 -2Pa, turn on the power supply of the gas source, implant argon ions into the surface of the material under the conditions of accelerating voltage 2.5kv, accelerating current 1mA, arc voltage 70v, and extraction voltage 600v, the implantation time is 5min, and the implantation dose is 2×10 15 ions / cm 2 , after the injection, turn off all the power sources of the gas source, and keep it under the argon atmosphere for 10 minutes, then take out the material to obtain a blood-compatible polyethylene non-woven fabric.

[0036] figure 1 It is the physical picture of the blood-compatible polye...

Embodiment 2

[0040] A method for preparing a blood-compatible medical polymer material, comprising the following steps:

[0041] Place a medical polypropylene sheet with a thickness of 0.2mm and a size of 5.0cm×10.0cm on the sample stage in the ion implantation equipment, seal the vacuum chamber of the equipment, and evacuate to 1×10 -3 Pa, through argon, the pressure is maintained at 1.0×10 -3 Pa, turn on the power supply of the gas source, implant argon ions into the surface of the material under the conditions of accelerating voltage 10kv, accelerating current 1mA, arc voltage 90v, and extraction voltage 500v, the implantation time is 10min, and the implantation dose is 4×10 15 ions / cm 2 After the injection, turn off the power supply of the gas source, and keep it under the argon atmosphere for 10 minutes, then turn off the argon gas; feed nitrogen gas, and maintain the pressure at 4.0×10 -3 Pa, turn on the gas source again, implant nitrogen ions into the surface of the material under...

Embodiment 3

[0044] A method for preparing a blood-compatible medical polymer material, comprising the following steps:

[0045] Place a medical polystyrene membrane with a thickness of 0.1mm and a size of 5.0cm×10.0cm on the sample stage in the ion implantation equipment, seal the vacuum chamber of the equipment, and evacuate to 1×10 -4 Pa, through helium, the pressure is maintained at 4.0×10 -3 Pa, turn on the power supply of the gas source, implant helium ions into the surface of the material under the conditions of accelerating voltage 10kv, accelerating current 1mA, arc voltage 90v, and extraction voltage 600v, the implantation time is 20min, and the implantation dose is 5×10 16 ions / cm 2 , after the injection, turn off the power supply of the gas source, and keep it under the helium atmosphere for 10 minutes; turn off the helium and inject ammonia gas, and maintain the pressure at 4.0×10 -3 Pa, turn on the gas source again, implant nitrogen ions into the surface of the material und...

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Abstract

The present invention discloses a preparation method for a medical polymer material with blood compatibility, wherein under a vacuum condition, inert gas ions are injected into the surface of a polymer material to form a carbon chain structure having C=C bond and C[triple-bond]C bond so as to finally obtain the medical polymer material with blood compatibility. According to the present invention, operations of the method are simple, physical and chemical structures of the material are not affected, and the medical film obtained after the treatment has characteristics of stable surface structure and excellent blood compatibility.

Description

technical field [0001] The invention relates to a preparation method of a blood-compatible medical polymer material, which belongs to the field of surface modification of medical polymer materials. Background technique [0002] At present, medical polymer materials are widely used in materials that come into contact with blood. Among them, the polymer materials implanted in the body include artificial blood vessels, vascular sutures, artificial heart valves, hernia repair sheets, artificial bone substitute materials, etc.; Wait. In the process of contact with blood, in order to avoid material contact thrombosis and coagulation, the material is required to have excellent blood compatibility, including a small adhesion to blood platelets, not to activate coagulation factors, or even to destroy blood red blood cells, so that Conducive to blood circulation or storage. Under such strict requirements, there are relatively few medical polymer materials that can be used in contac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/00C08J7/12C08L23/06C08L23/12C08L25/06C08L27/18C08L27/16C08L67/04C08L77/02C08L75/04C08L61/16C08L83/04D06M10/06
Inventor 张维季君晖
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI