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Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof

A technology for lowering blood sugar and composition, which is applied in the field of traditional Chinese medicine composition with lowering blood sugar effect and its preparation, which can solve problems such as gastrointestinal irritation, hypoglycemia reaction, blood phase liver function, kidney function damage, etc., and achieve non-toxic Effects of side effects, strict compatibility, and reasonable design

Inactive Publication Date: 2014-01-08
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of these oral chemicals are mainly manifested in the damage to the blood phase, liver function, and kidney function, which will cause diabetic cardiovascular and cerebrovascular complications, prone to hypoglycemia, irritating the gastrointestinal tract, and producing anorexia , nausea, vomiting, and even diarrhea
Therefore, it is urgent to choose high-efficiency and long-term use without any toxic and side effects, reliable curative effect, and convenient hypoglycemic drugs to take. Chinese medicine has certain curative effect for treating diabetes. The efficacy of traditional Chinese medicine preparations in treating diabetes is not significant, and the advantages of traditional Chinese medicine in treating diabetes cannot be brought into play

Method used

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  • Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof
  • Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof
  • Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of granule

[0024] Weigh and mix the medicinal materials according to the amount of each medicinal material in the above table, add water to decoct twice, add water for the first time to 8 times the weight of the medicinal materials, decoct for 1.5 hours, add water for the second time to 6 times the weight of the medicinal materials, and decoct for 1 hour , combined decoction, filtered, the filtrate was concentrated to a relative density of 1.10 (65°C), added an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 65%, stirred, left to stand for 24 hours, filtered, the filtrate recovered ethanol and concentrated to The concentrated solution with a relative density of 1.20 (65°C) is spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 70°C, the atomization pressure is 0.2 MPa, and the spray speed is 5ml / s.), crushed into dry extract...

Embodiment 2

[0025] Embodiment 2: the preparation of tablet

[0026] Weigh and mix the medicinal materials according to the amount of each medicinal material in the above table, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal materials, decoct for 1 hour, and combine Decoction, filter, concentrate the filtrate to a relative density of 1.15 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 75%, stir, let stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to a relative density 1.25 (65°C) concentrated solution, spray-dried (conditions are that the inlet air temperature is 120°C, the outlet air temperature is 90°C, the material temperature is 80°C, the atomization pressure is 0.3 MPa, and the spray speed is 7.5 / s. ), crushed into dry extract powder, then add an appropriate a...

Embodiment 3

[0027] Embodiment 3: the preparation of oral liquid

[0028] Weigh and mix the medicinal materials according to the amount of each medicinal material in the above table, add water to decoct twice, add water for the first time to 12 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal materials, and decoct for 2 hours, Combine the decoctions, filter, concentrate the filtrate to a relative density of 1.20 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 85%, stir, let stand for 24 hours, filter, recover the ethanol from the filtrate and concentrate to a relative The concentrated solution with a density of 1.30 (65° C.) is added with sucrose and 0.1% propionic acid or 0.1% to 0.25% sodium benzoate as preservatives to obtain a finished oral solution.

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Abstract

The invention discloses a traditional Chinese medicine composition with the effect of reducing blood sugar. The traditional Chinese medicine composition is prepared from the following active ingredients in parts by weight: 30-40 parts of membranous milkvetch root, 20-30 parts of sungrass, 15-25 parts of herb of goldencup St. John wort, 15-25 parts of Indian buead, 8-12 parts of largehead atractylodes rhizome and 8-12 parts of liquorice root. The traditional Chinese medicine composition can be in the form of granules, tablets, oral liquid and capsules. The invention further discloses a preparation method of the traditional Chinese medicine composition. The preparation method comprises the following steps: adding water for decoction, concentrating, performing alcohol precipitation, performing spray-drying, and adding auxiliary materials to prepare the composition. The invention also discloses application of the traditional Chinese medicine composition to preparation of medicaments with the effect of reducing blood sugar.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with hypoglycemic effect and its preparation method and application. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is due to defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. In addition to insulin, the current clinical treatment of type 2 drugs is mainly oral hypoglycemic drugs, which are roughly divided into sulfonylureas, biguanides, traditional Chinese medicine preparations, other hypoglycemic drugs and auxiliary drugs. However, the side effects of these oral chemicals are mainly manifested in the damage to the blood phase, liver function, and kidney function, which w...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K36/8969A61K36/484A61P3/10
Inventor 沈林林张畅斌
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE