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Pharmaceutical composition and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of increasing adverse reactions such as skin allergies, palpitations, shortness of breath, influence of blood and hematopoietic system, and unclear interaction, so as to improve hemodynamic function and myocardial hypoxia Effects of tolerance function, reduction of damage to brain tissue, and improvement of immune function

Inactive Publication Date: 2014-01-22
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] 2. Effects on blood and hematopoietic system
The patent also describes the preparation method of the composition. This invention adopts the method of separating and purifying the components first, and then mixing them. This not only discards many active ingredients, but also makes the preparation cost quite high
[0026] In addition, the prior art Panax notoginseng total saponins contain 5 quantifiable components with a total content of 65% to 80%, and also contain a considerable proportion of unknown impurities. It has brought many problems in application and application, and increased the probability of adverse reactions such as skin allergies, chills, papules, heart palpitations, shortness of breath, etc.

Method used

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  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof

Examples

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Embodiment 1

[0052] Embodiment 1, preparation pharmaceutical composition of the present invention

[0053] Weigh 10 kg of Panax notoginseng, infiltrate with 60-85% ethanol with a weight ratio of 1 times, soak softly, grind into a coarse powder by wet method, add 70% ethanol with 5, 6, and 6 times the weight of dry medicinal materials, and reflux extraction 3 times, 1 hour each time, collect the extract and filter. Take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, put it on a macroporous adsorption resin column D101 or HPD100, elute with water and 70% ethanol respectively, concentrate the alcohol eluent, and then put it on a macroporous adsorption resin column D101 or HPD100 Pore ​​ion exchange resin column, elute with 70% ethanol solution, collect the ethanol eluted part, concentrate under reduced pressure, concentrate the eluent, put it on an aluminum oxide column, elute with 85% ethanol, and concentrate...

Embodiment 2

[0066] Example 2 Preparation of the pharmaceutical composition of the present invention

[0067] Weigh 10 kg of Panax notoginseng, infiltrate with 60-85% ethanol with a weight ratio of 1 times, soak softly, wet grind into a coarse powder, add 80% ethanol with an amount of 8, 10, and 10 times the weight of the medicinal material, and reflux extraction 3 times, 1 hour each time, collect the extract and filter. Take the filtrate to recover ethanol until there is no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, put it on a macroporous adsorption resin column, elute with water and 75% ethanol respectively, concentrate the alcohol eluate, and then put it on a macroporous ion exchange Resin column, eluted with 75% ethanol, collected ethanol eluted part, concentrated under reduced pressure, concentrated eluent, put on aluminum oxide column, eluted with 80% ethanol, concentrated eluent. Recrystallize and refine with acetone, and dry to obtain the p...

Embodiment 3

[0070] Example 3 Preparation of the pharmaceutical composition of the present invention

[0071] Weigh 10 kg of Panax notoginseng, infiltrate with 1 times the weight of 85% ethanol, soak it softly, wet grind it into a coarse powder, add 85% ethanol whose weight is 13 times the weight of the dry medicinal material each time, and reflux extraction 4 times, Each time for 2 hours, the extract was collected and filtered. Take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, put it on a macroporous adsorption resin column, elute with water and 80% ethanol respectively, concentrate the alcohol eluate, and then put it on a macroporous ion exchange Resin column, eluted with 80% ethanol, collected ethanol eluted part, concentrated under reduced pressure, concentrated eluent, put on aluminum oxide column, eluted with 80% ethanol, concentrated eluent. Recrystallize and refine with acetone, and dry to obtain...

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Abstract

The invention provides a pharmaceutical composition. The pharmaceutical composition comprises the following components: ginsenoside Rb1, ginsenoside Rg1, notoginsenoside R1, ginsenoside Rd, ginsenoside Re, ginsenoside Rf, ginsenoside Rc, ginsenoside Rh1, ginsenoside Rb2 and ginsenoside Rg3. The invention further provides a preparation method of the pharmaceutical composition. The pharmaceutical composition disclosed by the invention has clear components, stable quality, good controllability, acute toxicity, undue toxicity and hemolysis in comparison with panax notoginseng saponins in the prior art. Test results indicate that the pharmaceutical composition disclosed by the invention has high safety and wide clinical application prospect.

Description

[0001] This application is a divisional application of a Chinese patent application submitted to the China Patent Office on September 24, 2009 with the application number 200910175602.x and the title of the invention "a pharmaceutical composition and its preparation method", the entire contents of which are incorporated by reference in this application. technical field [0002] The invention relates to the field of medicine, in particular to a pharmaceutical composition and a preparation method thereof. Background technique [0003] Panax notoginseng, ginseng and American ginseng belong to the genus Araliaceae, and all three are valuable Chinese medicinal materials. Modern studies on the chemical constituents of Panax notoginseng and ginseng have shown that Panax notoginseng saponins are similar to ginsenosides, both of which are mainly dammarane-type saponins, but the total saponins content of Panax notoginseng is high, and the meaningful ginsenoside Rb1 and Rg1 was higher...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/10A61P25/00A61P3/06
Inventor 张国丽王子幼杨兆祥
Owner KPC PHARM INC
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