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Porous material for tissue engineering stent

A tissue engineering scaffold and porous technology, applied in the field of biomedical materials, can solve problems such as unfavorable cell migration and growth

Inactive Publication Date: 2014-01-22
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since the internal interconnected channels between cells are mainly formed by the leaching of the co-continuous phase formed by biopolymers and water-soluble polymers, and the size of the co-continuous phase of water-soluble polymers is small, usually several Therefore, although the pores of the obtained product are connected to each other, the size of the connecting channel is small, only in the micron scale, and the obtained scaffold material is not conducive to the migration and growth of cells into the material, see figure 1

Method used

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  • Porous material for tissue engineering stent
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Examples

Experimental program
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Effect test

Embodiment 1

[0020] Polycaprolactone (granule), polyethylene oxide (powder), and sodium bicarbonate (powder) were prepared at a volume ratio of 1:1:1, and blended on a twin-screw extruder (BMP, US) and For granulation, the blending temperature was set at 100°C to prevent the premature decomposition of sodium bicarbonate. Then, injection foam molding was performed on a micro-foaming injection molding machine (Arburg Allrounder 320S equipped with Drexel Mucell gas supply system), and the molding temperature was set at 155°C (at this temperature, the thermal decomposition rate of sodium bicarbonate reached the maximum), and micropores were obtained. Foam injection molding products. Then put the injection molded product in a circulating water bath and leach for 72 hours to leach out sodium carbonate, the decomposition product of polyethylene oxide and sodium bicarbonate, and finally dry it in a vacuum oven for 48 hours to obtain an interconnected porous material . The porosity of the resulti...

Embodiment 2

[0022] Polycaprolactone (granular), polyethylene oxide (powder), and sodium bicarbonate (powder) were prepared according to the volume ratio of 3:2:3. Under the same steps and conditions as in Example 1, the internal The interconnected porous material has a porosity of 73.8%, a cell size of 20 microns to 250 microns, and an internal interconnected channel size of 20 microns to 200 microns.

Embodiment 3

[0024] Polycaprolactone (granular), polyethylene oxide (powder), and sodium bicarbonate (powder) were prepared according to a volume ratio of 2:3:2, and under the same steps and conditions as in Example 1, prepared The internal interconnected porous material has a porosity of 70.9%, a cell size of 20 microns to 250 microns, and an internal interconnected channel size of 20 microns to 200 microns.

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Abstract

The invention discloses a porous material for a tissue engineering stent. The porous material for the tissue engineering stent is prepared from 25-40% of polycaprolactone, 30-45% of polyethylene oxide and 25-40% of sodium bicarbonate according to a method as follows: uniformly mixing the raw materials; extruding in a twin-screw extruder for granulating; foaming and moulding by a conventional microporous foaming and moulding technology to obtain an intermediate product; leaching the obtained intermediate product in a circulating water bath; and performing vacuum drying to obtain a porous material with the porosity of 68-74.0%, the pore size of 20-200 microns, and the sizes of internal intercommunicating passages of about 20-200 microns. The porous material for the tissue engineering stent has the advantages as follows: in the foaming process, not only supercritical carbon dioxide for microporous foaming and moulding can generate a foaming action, but also gas obtained by decomposing sodium bicarbonate can generate a foaming action, so that by a combined physical and chemical foaming method, the finally obtained porous material can meet a growth requirement of a biological cell.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a porous material for tissue engineering scaffolds interconnected inside. Background technique [0002] Tissue engineering scaffold material is a material that can be combined with tissue living cells and can be implanted in organisms. It can provide cells with a place to obtain nutrients, gas exchange, excrete waste, and grow and develop. The material basis of organs. [0003] The interconnected porous structure is one of the structural characteristics of tissue engineering scaffolds. The porous structure is conducive to the attachment and growth of cells on the scaffold, and the internal interconnection provides channels for the nutrients and waste metabolism required by cells, and also ensures that cells migrate into the scaffold material. At present, there are many methods for producing porous materials, such as thermally induced phase separation, freeze drying, 3D print...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/56
Inventor 李倩王小峰刘斐斐赵娜蒋晶侯建华徐轶洋
Owner ZHENGZHOU UNIV
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