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Surface direct mesoporous modification method used for multi-morphology rear earth-doped up-conversion luminescent nanocrystallines

A rare earth up-conversion and nanocrystalline technology, which is applied in the fields of nanotechnology, nanotechnology, nano-optics, etc. for materials and surface science, can solve the problems of many processes, difficulties, long periods, etc., to simplify the synthesis process and synthesis method. Simple, easy-to-repeat effects

Inactive Publication Date: 2014-01-29
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, rare earth upconversion luminescent nanocrystals coated with mesoporous SiO 2 Most of the preparation methods are "two-step method", that is, a layer of non-porous SiO is grown on the surface of nanocrystals first. 2 , and then use this as the nucleus to grow mesoporous SiO 2 , but the above method has many procedures and a long cycle
In addition, it is difficult to control the dispersion of nanoparticles in the process of ammonia water-catalyzed mesoporous modification reaction, and the phenomenon of "one pack" is easy to appear, and the particle size is large, so the morphology and stability of the obtained materials are easily affected

Method used

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  • Surface direct mesoporous modification method used for multi-morphology rear earth-doped up-conversion luminescent nanocrystallines
  • Surface direct mesoporous modification method used for multi-morphology rear earth-doped up-conversion luminescent nanocrystallines
  • Surface direct mesoporous modification method used for multi-morphology rear earth-doped up-conversion luminescent nanocrystallines

Examples

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Embodiment 1

[0038] This embodiment provides a preparation method for direct mesoporous modification of the surface of multi-morphological rare earth upconversion luminescent nanocrystals, which includes the following steps:

[0039] (1) Convert hydrophobic rare earth up-conversion nanocrystals to hydrophilic to form the first dispersion;

[0040] (2) Thoroughly mix CTAB, deionized water, ethanol and sodium hydroxide solution to form a second dispersion, add the first dispersion to the second dispersion, stir and heat;

[0041] (3) Add silicon source TEOS to the mixed solution of the first and second dispersion liquids to generate mesoporous fluorescent multifunctional nanorod products;

[0042] (4) The template agent CTAB was removed from the nanorod-shaped product to obtain a multifunctional mesoporous nanoluminescent material in which the mesoporous directly coated the upconversion nanocrystal.

[0043] The step (1) specifically includes the following steps:

[0044] (1.1) Prepare 10-...

Embodiment 2

[0062] This example provides a preparation method for direct mesoporous modification of the surface of multi-morphological rare earth upconversion luminescent nanocrystals. The basic steps are the same as those in Example 1, except that the following specific steps are different:

[0063] (1) Prepare 10-15 mg of hydrophobic NaYF with a particle size of 30-60 nm 4 : Yb, Er, Mn crystals are dispersed in cyclohexane to form the first mixed solution; prepare 100 mg CTAB and 20 mL deionized water, mix and dissolve CTAB and deionized water to form the second mixed solution; 1. The second mixed liquid was mixed and fully stirred for 3 hours, while stirring, it was heated to 80° C. to evaporate and remove cyclohexane until a colorless and transparent solution was formed, that is, the first dispersion liquid.

[0064] (2) Prepare 0.2g CTAB, 3mL ethanol, 10-30mL deionized water, and 0.5mL 0.4mol / L NaOH solution, and mix the four substances evenly to prepare the second dispersion liquid....

Embodiment 3

[0068] This example provides a preparation method for direct mesoporous modification of the surface of multi-morphological rare earth upconversion luminescent nanocrystals. The basic steps are the same as those in Example 1, except that the following specific steps are different:

[0069] (1) Prepare 10-15 mg of hydrophobic NaYF with a particle size of 30-60 nm 4 : Yb, Er are dispersed in cyclohexane to form the first mixed solution; prepare 100 mg CTAB and 20 mL deionized water, mix and dissolve CTAB and deionized water to form the second mixed solution; mix the first and second The mixture was mixed and fully stirred for 3 hours, while stirring, it was heated to 80° C. to evaporate and remove cyclohexane until a colorless and transparent solution was formed, that is, the first dispersion.

[0070] (2) Prepare 0.2g CTAB, 3mL ethanol, 10-30mL deionized water, and 0.5mL 0.4mol / L NaOH solution, and mix the four substances evenly to prepare the second dispersion liquid.

[0071]...

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Abstract

The invention discloses a surface direct mesoporous modification method used for multi-morphology rare earth up-conversion luminescent nanocrystallines. The surface direct mesoporous modification method comprises following steps: firstly, the multi-morphology rare earth up-conversion luminescent nanocrystallines are taken as a core, hexadecyl trimethyl ammonium bromide is taken as an adjuvant agent, and the hydrophobic rare earth up-conversion luminescent nanocrystallines are transformed into hydrophilic rare earth up-conversion luminescent nanocrystallines; the hydrophilic rare earth up-conversion luminescent nanocrystallines are dispersed in a mixed solution; ethyl orthosilicate is added dropwise so as to obtain rare earth up-conversion luminescent nanocrystallines directly coated by mesoporous silica; and the template agent is removed so as to obtain a multi-functional mesoporous nano fluorescent material. The multi-functional mesoporous nano fluorescent material prepared by the ''one-step method'' is uniform in size, and stable in structure, and possesses advantages such as high fluorescence intensity and large specific surface area. The obtained multi-functional mesoporous nano fluorescent material possesses potential application values in fields of up-conversion luminescent mark of cells or tissues, medicine carrying and targeted tumor therapy.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to a preparation method for direct mesoporous modification on the surface of multi-morphology rare earth up-conversion luminescent nanocrystals. Background technique [0002] The combination and assembly of different functional nanomaterials can well promote the development of multifunctional nanoplatforms for multimodal bioimaging and therapy. With the development of nanotechnology, multifunctional nanoorganisms with fluorescence and mesoporous structure properties have received extensive attention. Multifunctional mesoporous nanomaterials have many advantages. On the one hand, biological tissues can be labeled for real-time observation in vivo. On the other hand, through further targeted modification, the anticancer drugs loaded in the mesoporous structure can be released to specific tumors under targeted action. Cells or cancer cell areas, kill canc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/85G01N21/64B82Y30/00B82Y20/00B82Y40/00
Inventor 孙丽宁施利毅刘涛仇衍楠刘金亮王志娟
Owner SHANGHAI UNIV