Preparation method of nucleotide-rare earth coordination polymer light-emitting material

A technology of coordination polymers and luminescent materials, applied in luminescent materials, chemical instruments and methods, compounds containing elements of Group 3/13 of the periodic table, etc., can solve problems such as poor hydrophilicity and biocompatibility, and achieve Good hydrophilicity and biocompatibility, high luminescence intensity, avoiding the effect of complex synthesis

Active Publication Date: 2014-02-05
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Deficiencies in the prior art: The reported preparation of rare earth coordination polymers is mainly through hydrothermal reaction, the reaction temperature is above 100°C, the reaction time is as long as ten hours to several days, and some requir

Method used

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  • Preparation method of nucleotide-rare earth coordination polymer light-emitting material
  • Preparation method of nucleotide-rare earth coordination polymer light-emitting material
  • Preparation method of nucleotide-rare earth coordination polymer light-emitting material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of adenosine monophosphate-terbium-pyridinedicarboxylic acid (AMP-Tb-DPA) coordination polymer

[0025] In 0.5mL N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) buffer (100mM, pH7.4) containing 10mM adenosine monophosphate (AMP), add 0.5mL concentration of 10mM Tb(NO 3 ) 3 Aqueous solution and 0.5mL dipicolinic acid (DPA) aqueous solution with a concentration of 10mM produced a white precipitate. The solution continued to react for 3 hours under stirring, and the precipitate was collected by centrifugation (6000rpm×10min). The obtained precipitate was washed with deionized water and centrifuged. Separation, washing with deionized water was repeated three times, and finally, the precipitate was dried in an oven at 70°C, and stored in a desiccator after drying.

[0026] figure 1 It is the transmission electron microscope image of the prepared adenosine monophosphate-terbium-pyridinedicarboxylic acid (AMP-Tb-DPA) coordination polymer, ...

Embodiment 2

[0027] Example 2: Preparation of adenosine monophosphate-europium-tetracycline (AMP-Eu-Tc) coordination polymer

[0028] In 2 mL of N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) buffer (100 mM, pH 7.4) containing 10 mM adenosine monophosphate (AMP), add 1.5 mL of 10 mM Eu(NO 3 ) 3 Aqueous solution and 0.5mL tetracycline (Tc) aqueous solution with a concentration of 10mM produced a white precipitate, the solution continued to react for 3 hours under stirring, centrifuged (14000rpm×10min) to collect the precipitate, the obtained precipitate was washed with deionized water, centrifuged, repeated Wash with deionized water three times, and finally, dry the precipitate in an oven at 70°C, and store it in a desiccator after drying.

[0029] image 3 It is a transmission electron micrograph of the prepared adenosine monophosphate-europium-tetracycline (AMP-Eu-Tc) coordination polymer, and the coordination polymer shows a network nanostructure. Figure 4 It is the flu...

Embodiment 3

[0030] Example 3: Preparation of adenosine diphosphate-terbium-phenanthroline (ADP-Tb-Phen) coordination polymer

[0031] In 1 mL of N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) buffer (100 mM, pH 7.4) containing 3 mM adenosine diphosphate (ADP), add 1 mL of 3 mM Tb(NO 3 ) 3 Aqueous solution, then add 2mL of 1.5mM o-phenanthroline (Phen) aqueous solution, stir the mixed solution at room temperature for 3h, centrifuge at 10000rpm for 20min to collect the precipitate, wash the resulting precipitate with deionized water to remove unreacted reagents, centrifuge, Washing with deionized water was repeated three times, and finally, the precipitate was dried in an oven at 70°C, and stored in a desiccator after drying.

[0032] Figure 5 It is the transmission electron micrograph of the prepared adenosine diphosphate-terbium-phenanthroline (ADP-Tb-Phen) coordination polymer, and the coordination polymer shows a network nanostructure. Figure 6 It is the fluorescence sp...

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Abstract

The invention relates to a preparation method of a nucleotide-rare earth coordination polymer light-emitting material. According to the method, a hydrophilic light-emitting rare earth coordination polymer material is prepared from biomolecules including nucleotide, rare earth ions and micromolecule ligands through molecular self-assembling. According to the preparation method, because biomolecules are used as components, the prepared nucleotide-rare earth coordination polymer light-emitting material not only has a high light-emitting intensity, but also has good biocompatibility and hydrophily; through adoption of molecular self-assembling for preparation, the reaction is performed at room temperature and the conditions of a high temperature and a long reaction time, required by usual preparation, are not needed; therefore, the method is simple and easy to operate. The prepared light-emitting material has a good application prospect on the aspects of molecular sensing, tracer imaging, drug delivery, and the like.

Description

technical field [0001] The invention relates to a preparation method of a nucleotide rare earth coordination polymer luminescent material. The prepared nucleotide rare earth coordination polymer luminescent material can be used for sensing, marking and imaging of molecules / ions, and belongs to the preparation of rare earth luminescent nanomaterials field. Background technique [0002] Fluorescence technology has a wide range of applications in life sciences, medicine, food safety, environmental protection and other fields. Traditional fluorescence analysis mainly uses various organic dye molecules. Since the excitation wavelength of organic dye molecules is close to the emission wavelength, the Stokes shift is small (20-30nm), and the detection is easily interfered by excitation light; organic dye molecules are also prone to photobleaching. and quenching effect, leading to a decrease in fluorescence intensity. In addition, in fluorescence analysis, especially the fluoresce...

Claims

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Application Information

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IPC IPC(8): C07F5/00C09K11/06
Inventor 陈扬尤其刘保霞
Owner SOUTHEAST UNIV
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