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Electrochemical detection method of acetaminophen medicine by PEDOT (Polymer Ethylenedioxy Thiophene)/GO (Graphene Oxide)/GCE (Glassy Carbon Electrode)

A paracetamol and detection method technology, applied in the field of electrochemical analysis and detection, can solve the problem of no peak shape, etc., achieve low detection limit, wide linear range, and good electroactivity

Active Publication Date: 2014-02-26
昆山市华滤环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The detection of acetaminophen by electrochemical method has been reported earlier, Hanieh Ghadimi et al. - Vinylpyridine) / multi-walled carbon nanotube modified glassy carbon electrode as the working electrode for electrochemical determination of acetaminophen in phosphate buffer solution with pH=7.0, high response sensitivity, good stability, linear range of 0.02-450 μmol / L, the biggest disadvantage of this modified electrode to detect acetaminophen is that there is no good peak shape

Method used

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  • Electrochemical detection method of acetaminophen medicine by PEDOT (Polymer Ethylenedioxy Thiophene)/GO (Graphene Oxide)/GCE (Glassy Carbon Electrode)
  • Electrochemical detection method of acetaminophen medicine by PEDOT (Polymer Ethylenedioxy Thiophene)/GO (Graphene Oxide)/GCE (Glassy Carbon Electrode)
  • Electrochemical detection method of acetaminophen medicine by PEDOT (Polymer Ethylenedioxy Thiophene)/GO (Graphene Oxide)/GCE (Glassy Carbon Electrode)

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Experimental program
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Embodiment 1

[0021] A kind of electrochemical detection method based on PEDOT / GO / GCE electrode to drug paracetamol, described method comprises the following steps:

[0022] (1) Preparation of PEDOT / GO / GCE electrode: Add pure 3,4 ethylenedioxythiophene monomer dropwise to the graphene oxide dispersion, and then ultrasonicate for half an hour to obtain 3,4 ethylenedioxythiophene monomer and graphene oxide mixed solution, the clean glassy carbon electrode was placed in the mixed solution, the potential range was 0.2 ~ 1.2V cyclic voltammetry polymerization for 5 cycles, and the scan rate was 100 mV / s to obtain the PEDOT / GO / GCE electrode.

[0023] (2) Place the PEDOT / GO / GCE electrode obtained in step (1) in a buffer solution with a pH value of 2.8, add a certain amount of acetaminophen, and use cyclic voltammetry at a scan rate of 100 mV / s to detect Electrochemical response of PEDOT / GO / GCE electrode to acetaminophen.

[0024] Among them, the amount of pure 3,4 ethylenedioxythiophene monom...

Embodiment 2

[0031] A kind of electrochemical detection method based on PEDOT / GO / GCE electrode to drug paracetamol, described method comprises the following steps:

[0032] (1) Preparation of PEDOT / GO / GCE electrode: Add pure 3,4 ethylenedioxythiophene monomer dropwise to the graphene oxide dispersion, and then ultrasonicate for half an hour to obtain 3,4 ethylenedioxythiophene monomer and graphene oxide mixed solution, the clean glassy carbon electrode was placed in the mixed solution, the potential range was 0.2 ~ 1.2V cyclic voltammetry polymerization for 30 cycles, and the scan rate was 100 mV / s to obtain the PEDOT / GO / GCE electrode.

[0033] (2) Place the PEDOT / GO / GCE electrode obtained in step (1) in a buffer solution with a pH value of 7.0, add a certain amount of acetaminophen, and use cyclic voltammetry with a scanning speed of 300 mV / s to detect Electrochemical response of PEDOT / GO / GCE electrode to acetaminophen.

[0034] Among them, the amount of pure 3,4 ethylenedioxythiophe...

Embodiment 3

[0038] A kind of electrochemical detection method based on PEDOT / GO / GCE electrode to drug paracetamol, described method comprises the following steps:

[0039] (1) Preparation of PEDOT / GO / GCE electrode: Add pure 3,4 ethylenedioxythiophene monomer dropwise to the graphene oxide dispersion, and then ultrasonicate for half an hour to obtain 3,4 ethylenedioxythiophene monomer and graphene oxide mixed solution, the clean glassy carbon electrode was placed in the mixed solution, the potential range was 0.2 ~ 1.2V cyclic voltammetry polymerization for 15 cycles, and the scan rate was 100 mV / s to obtain the PEDOT / GO / GCE electrode.

[0040](2) Place the PEDOT / GO / GCE electrode obtained in step (1) in a buffer solution with a pH value of 5.0, add a certain amount of acetaminophen, and use cyclic voltammetry with a scanning speed of 200 mV / s to detect Electrochemical response of PEDOT / GO / GCE electrode to acetaminophen.

[0041] Among them, the amount of pure 3,4-ethylenedioxythiophen...

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Abstract

The invention discloses an electrochemical detection method of an acetaminophen medicine by a PEDOT (Polymer Ethylenedioxy Thiophene) / GO (Graphene Oxide) / GCE (Glassy Carbon Electrode). The electrochemical detection method comprises the steps of ultrasonically dispersing oxidized graphene and 3,4 ethylene dioxo thiophene monomer in an aqueous solution, preparing PEDOT / GO / GCE in a three-electrode system through electrochemical polymerization and carrying out electrochemical detection on the acetaminophen by the modified electrode. A preparation method of the PEDOT / GO / GCE is simple in process, non-toxic, environment-friendly and low in cost. The modified electrode can be used for detecting the acetaminophen medicine and has the characteristics of rapid response time, wide linear range, good reproducibility, high stability and the like.

Description

technical field [0001] The invention belongs to the technical field of electrochemical analysis and detection, and in particular relates to an electrochemical detection method for paracetamol by a PEDOT / GO / GCE electrode. Background technique [0002] Graphene is a single-layer two-dimensional crystal composed of carbon atoms arranged in a honeycomb lattice with sp2 hybridization. It has unique electronic properties, thermal properties, mechanical properties and large specific surface area. It has been used in electrochemical supercapacitors, electrochemical sensors and widely used in biosensors. Graphene oxide (GO) is the most important derivative of graphene, which introduces a large number of oxygen-containing groups while maintaining the graphene sheet structure and mechanical properties, making it easier to modify. PEDOT is a conductive polymer with excellent performance. The special structure of the monomer makes PEDOT have many characteristics, mainly including the fo...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
Inventor 雷武韩振司维蒙郝青丽夏明珠王风云
Owner 昆山市华滤环保科技有限公司
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