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A kind of preparation method of Analgin tablet

An analgin and adhesive technology, applied in the field of medicine, can solve problems such as inability to guarantee product quality and drug safety, inability to guarantee quality standards, and influence of product content detection, and achieve simple methods, convenient operation, and guaranteed stability. sexual effect

Active Publication Date: 2016-02-03
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The original production process of Analgin tablets has a certain impact on the content detection of the product, and it cannot guarantee that the relevant substances meet the quality standards during the storage period of the product. Ensure product quality and drug safety

Method used

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  • A kind of preparation method of Analgin tablet
  • A kind of preparation method of Analgin tablet
  • A kind of preparation method of Analgin tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Analgin 40.00%

[0072] Sodium Carboxymethyl Cellulose 36.00%

[0073] Hypromellose 11.00%

[0074] Dextrin 5.00%

[0075] Microcrystalline Cellulose 3.00%

[0076] Crospovidone 2.00%

[0077] Magnesium Stearate 1.20%

[0078] Silica 1.80%

[0079] Take Sulpyrine, carboxymethylcellulose, sodium hypromellose, dextrin, microcrystalline cellulose, crospovidone, magnesium stearate, and silicon dioxide and sieve through 60 meshes respectively, and hypromellose Add 95% ethanol to cellulose to prepare a binder solution with a mass concentration of 30%, mix metamizol, carboxymethyl cellulose, dextrin, microcrystalline cellulose, and crospovidone, and add the aforementioned binder Solution-made soft material, granulated with 12 mesh, dried at 60°C, granulated with 12 mesh, added magnesium stearate and silicon dioxide, mixed evenly, and compressed into tablets.

Embodiment 2

[0081] Analgin 89.00%

[0082] Starch 2.10%

[0083] Microcrystalline Cellulose 0.70%

[0084] Hypromellose 2.90%

[0085] Carboxymethyl starch sodium 2.70%

[0086] Magnesium Stearate 0.90%

[0087] Talc powder 1.70%

[0088] Analgin, starch, microcrystalline cellulose, hydroxypropyl cellulose, carboxymethyl starch sodium, magnesium stearate, and talcum powder were sieved to 80 meshes respectively, and the starch was added with water to prepare a binder solution with a mass concentration of 16%. Mix Analgin with microcrystalline cellulose and hydroxypropyl cellulose, add the aforementioned binder solution to make a soft material, granulate at 16 mesh, dry at 80°C, granulate at 16 mesh, add sodium carboxymethyl starch and stearic acid Magnesium and talcum powder are mixed uniformly and pressed into tablets.

Embodiment 3

[0090] Analgin 42.00%

[0091] Calcium sulfate 47.70%

[0092] Starch 2.30%

[0093] Microcrystalline Cellulose 3.40%

[0094] Hypromellose 1.20%

[0095] Carboxymethyl Starch Sodium 1.30%

[0096] Magnesium Stearate 0.70%

[0097] Talc powder 1.40%

[0098] Analgin, calcium sulfate, starch, microcrystalline cellulose, hydroxypropyl cellulose, carboxymethyl starch sodium, magnesium stearate, and talcum powder were sieved to 80 meshes respectively, and the starch was added with water to make a 16% mass concentration adhesive agent solution, mix analgin, calcium sulfate, microcrystalline cellulose, and hydroxypropyl cellulose, add the above-mentioned adhesive solution to make a soft material, granulate at 16 mesh, dry at 80°C, granulate at 16 mesh, add carboxymethyl Sodium starch, magnesium stearate, and talcum powder are mixed evenly, and compressed into tablets.

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Abstract

The invention relates to a preparation method of an analgin tablet. The method comprises the following steps: respectively passing analgin, a filler, an adhesive, a disintegrant and a lubricant through a 60-100-mesh screen, adding water or 50-95 wt% ethanol into 40-100 wt% of the adhesive to prepare a 1-30 wt% adhesive solution, evenly mixing the rest of adhesive with the filler, analgin and 40-100 wt% of disintegrant, adding the adhesive solution to prepare a soft material, making 12-30-mesh granules, drying at 60-80 DEG C, finishing the 12-30-mesh granules, adding the rest of disintegrant, lubricant and a flow aid, uniformly mixing and tabletting. By adopting the reasonable technological operation sequence, the method is simple and convenient to operate, and suitable for industrial production. The method ensures the stability of analgin and can ensure that all the indexes of the product are acceptable, and related substances of the product are not overproof in the storage period.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a method for preparing Analgin tablets. Background technique [0002] Analgin (MetamizoleSodium Tablets), a common prescription medical insurance drug. It is a compound combining aminopyrine and sodium sulfite, easily soluble in water, and has faster and stronger antipyretic and analgesic effects than aminopyrine. It is generally used for emergency fever reduction in cases of acute high fever, severe illness, and no other effective antipyretic drugs available. [0003] Analgin belongs to antipyretic analgesic and non-steroidal anti-inflammatory analgesic drugs. Analgin acts on the thermoregulation center to dilate blood vessels in the skin, accelerate blood flow, increase sweating, accelerate heat dissipation and lower body temperature. [0004] The content determination of Analgin Tablets has long been based on the iodometric method. The first supplementary edition of the 2...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4152A61P29/00
Inventor 李俊朱光花梅艳冯春杨丽芬李云仙叶亚斌段昆花张雅婷
Owner YUNNAN PHYTOPHARML