Method for preparing nano-fiber-based guided bone regeneration membrane
A technology for guiding bone regeneration and nanofibers, which is used in medical science, textiles and papermaking, non-woven fabrics, etc. It can solve problems such as insufficient adhesion, failure, and poor mechanical properties of materials, and achieve good tensile properties. The effect of mechanical properties
Inactive Publication Date: 2014-03-05
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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The invention relates to the preparation of a hydroxyapatite-grafted polylactide/polylactic acid-copolymerized glycolic acid electrospun nano-fiber-based guided bone regeneration membrane. The membrane is prepared from a mixture of HA-g-PLLA (hydroxyapatite-grafted poly-L-lactic acid) nanoparticles and PLGA (poly(L-co-glycolic acid) by an electrospinning method, i.e., the novel biodegradable guided bone regeneration membrane is constructed. Compared with PLGA and HAP/PLA fiber membranes, the prepared HA-g-PLLA/PLGA composite fiber membrane has the advantages that high mechanical performance is achieved, the adhesion and ductility of osteoblasts on the surface of the membrane are superior to those of the other composite membranes, and the HA-g-PLLA/PLGA composite fiber membrane has a broad application prospect in the treatment of guided bone regeneration.
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