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Method for preparing nano-fiber-based guided bone regeneration membrane

A technology for guiding bone regeneration and nanofibers, which is used in medical science, textiles and papermaking, non-woven fabrics, etc. It can solve problems such as insufficient adhesion, failure, and poor mechanical properties of materials, and achieve good tensile properties. The effect of mechanical properties

Inactive Publication Date: 2014-03-05
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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Problems solved by technology

However, the insufficient adhesion between HA nanoparticles and PLGA substrates also led to the failure of early studies on the HA-polymer interface, that is, the mechanical properties of the prepared materials were not good.

Method used

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Embodiment Construction

[0009] In order to deepen the understanding of the present invention, the present invention will be further described in detail below in conjunction with specific examples:

[0010] (1) Solution preparation: A certain amount of HA grafted PLLA or HA powder is dispersed into 25 times (weight) of chloroform, and then the suspension is poured into a 10wt% PLGA / chloroform solution to obtain 15wt% HA grafts PLLA or a mixture of HA, and the resulting mixture is dissolved in chloroform to form a milky suspension. The mass fraction of the initial PLGA in each solution was maintained at 10% by weight, and triethylphenylammonium chloride with a polymer concentration of 8% by weight was added to the above suspension to improve the spinnability of electrospinning. 10% by weight PLGA solution is used as a control liquid.

[0011] (2) Preparation of the electrospun fiber membrane: The solution is put into a 10mL syringe equipped with a metal needle, the inner diameter of the needle is 0.5mm, th...

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Abstract

The invention relates to the preparation of a hydroxyapatite-grafted polylactide / polylactic acid-copolymerized glycolic acid electrospun nano-fiber-based guided bone regeneration membrane. The membrane is prepared from a mixture of HA-g-PLLA (hydroxyapatite-grafted poly-L-lactic acid) nanoparticles and PLGA (poly(L-co-glycolic acid) by an electrospinning method, i.e., the novel biodegradable guided bone regeneration membrane is constructed. Compared with PLGA and HAP / PLA fiber membranes, the prepared HA-g-PLLA / PLGA composite fiber membrane has the advantages that high mechanical performance is achieved, the adhesion and ductility of osteoblasts on the surface of the membrane are superior to those of the other composite membranes, and the HA-g-PLLA / PLGA composite fiber membrane has a broad application prospect in the treatment of guided bone regeneration.

Description

Technical field [0001] The invention relates to a preparation of a guided bone regeneration membrane, in particular to a preparation of a guided bone regeneration membrane based on hydroxyapatite grafted polylactide / polylactic acid copolymer polyglycolic acid electrospun nanofiber. Background technique [0002] Guided bone regeneration (GBR) is a treatment method for bone rehabilitation in the clinical field. Guided bone regeneration uses a barrier membrane to organize the ingrowth of fibrous tissue to guide bone reconstruction to achieve new bone growth. . A membrane used to guide bone regeneration is non-degradable polytetrafluoroethylene, but it must be removed by a second operation, which increases the patient's risk of infection and other harmful side effects. [0003] Bioabsorbable membrane has attracted a lot of attention because it can avoid secondary operations, and it can also reduce the incidence of tissue and the loss of new bone. Biodegradable polymers, such as polyl...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/02D04H1/4382D04H1/728
Inventor 韩志超许杉杉佴刚
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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