Method for preparing nano-fiber-based guided bone regeneration membrane
A technology for guiding bone regeneration and nanofibers, which is used in medical science, textiles and papermaking, non-woven fabrics, etc. It can solve problems such as insufficient adhesion, failure, and poor mechanical properties of materials, and achieve good tensile properties. The effect of mechanical properties
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[0009] In order to deepen the understanding of the present invention, the present invention will be further described in detail below in conjunction with specific examples:
[0010] (1) Solution preparation: A certain amount of HA grafted PLLA or HA powder is dispersed into 25 times (weight) of chloroform, and then the suspension is poured into a 10wt% PLGA / chloroform solution to obtain 15wt% HA grafts PLLA or a mixture of HA, and the resulting mixture is dissolved in chloroform to form a milky suspension. The mass fraction of the initial PLGA in each solution was maintained at 10% by weight, and triethylphenylammonium chloride with a polymer concentration of 8% by weight was added to the above suspension to improve the spinnability of electrospinning. 10% by weight PLGA solution is used as a control liquid.
[0011] (2) Preparation of the electrospun fiber membrane: The solution is put into a 10mL syringe equipped with a metal needle, the inner diameter of the needle is 0.5mm, th...
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