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Application of anhydroicaritin in preparation of drugs used for treating asthma

A technology of icariin and usage, which is applied in the field of medicine, can solve the problem that the anti-asthma effect of guinea pig bronchial asthma is not ideal, and achieve the effect of reducing IgE content and EOS cell rate, reducing treatment costs, and low price

Inactive Publication Date: 2014-03-12
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have proved that Epimedium extract has certain antitussive and expectorant effects, but the antiasthmatic effect on guinea pig bronchial asthma is not ideal
There is no report on the treatment of asthma with icarigenin

Method used

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  • Application of anhydroicaritin in preparation of drugs used for treating asthma
  • Application of anhydroicaritin in preparation of drugs used for treating asthma
  • Application of anhydroicaritin in preparation of drugs used for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 icarigenin injection

[0018]

[0019]

[0020] Preparation Process:

[0021] Mix the prescribed amount of propylene glycol and ethanol evenly, add icariin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain the product.

Embodiment 2

[0022] Embodiment 2 icarigenin tablet

[0023]

[0024] Preparation process: icariin is passed through a 100-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose are passed through a 80-mesh sieve, and the prescribed amount of icariin and low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and microcrystalline cellulose are weighed. Mix crystal cellulose evenly, add appropriate amount of 8% hydroxypropyl methylcellulose solution to granulate, dry at 60°C, sieve through a 16-mesh sieve, add prescription amount of magnesium stearate to the dry granules, mix evenly, and compress into tablets.

Embodiment 3

[0025] Example 3 Icarigenin enteric-coated tablet

[0026]

[0027] Preparation process: According to the conventional tablet process, it is made into tablets (ball cores) of required specifications, and then coated with enteric coating powder.

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Abstract

The invention provides application of anhydroicaritin in preparation of drugs used for treating asthma, which belongs to the field of medicine. Anhydroicaritin is a Chinese herbal monomer extracted from the traditional Chinese medicine epimedium; when used for treating asthma, anhydroicaritin can substantially reduce total IgE content in the serum of a patient with asthma and the rates of IL-4, IFN-r and eosinophilic granulocytes in the pulmonary alveoli of the patient, and anhydroicaritin has a better treatment effect on the patient with asthma compared with those of an epimedium extract and icariin. Anhydroicaritin has the advantages of comprehensive effects, small side effects and wide clinical application prospects when used for treatment of asthma.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new medical application of icariin, in particular to the application of icariin in preparing medicine for treating asthma. Background technique [0002] Bronchial asthma (referred to as asthma) is a common and frequently-occurring disease. At present, there are about 300 million asthma patients in the world, and about 30 million asthma patients in China. Asthma is a chronic disease that has a significant impact on patients, their families and society. If it is not treated in a timely and non-standard manner, it is very likely to be life-threatening. The risk factors for the onset of asthma include host factors and environmental factors, but the specific pathogenesis is still not completely clear. The possible pathogenesis includes allergy, chronic airway inflammation, airway hyperresponsiveness, and airway neuroregulation disorders. , genetic mechanism, respiratory virus infection, neura...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/06
Inventor 赵志全刘奋徐真真
Owner LUNAN PHARMA GROUP CORPORATION
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