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Cool massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain and preparation method thereof

A technology for promoting blood circulation and removing blood stasis and reconciling collaterals, applied in the field of medicine, can solve the problems that massage ointment cannot fully exert its medicinal effect, cold resistance and heat resistance oil-water separation, poor particle size distribution uniformity, etc. The effect of stable quality and high yield

Active Publication Date: 2018-05-01
SHINEWAY PHARMA GRP SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, the preparation method given by Pharmacopoeia Massage Ointment also has certain defects.
The characteristic of this pharmacopoeia method is that after mixing the raw and auxiliary materials, add the traditional Chinese medicine extract, add water, heat, stir, and emulsify. Sexual oil-water separation phenomenon, and centrifugal test layering phenomenon, the yield of the product needs to be improved
In addition, the particle size of the cream prepared by this method is relatively large, and the uniformity of the particle size distribution is poor, which affects the transdermal absorption of the drug, and the massage ointment cannot fully exert the drug effect.

Method used

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  • Cool massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain and preparation method thereof
  • Cool massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain and preparation method thereof
  • Cool massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]

[0031] The preparation method of massage ointment comprises: (1) preparation of Chinese medicine extract: get frankincense, myrrh, black medicine, chuanxiong, turmeric decoction pieces, add 50% ethanol of 5 times the amount of decoction pieces, soak and extract 5 times, each time After 10 days, combine the extracts, add rue extract and belladonna liquid extract, stir well, filter, and adjust the relative density of the filtrate to 20°C to be 0.85 for later use; (2) prepare the oil phase: stearic acid, mono Glyceryl stearate, stearyl alcohol, methyl salicylate, menthol, peppermint oil, azone, camphor, clove oil, borneol, menthyl lactate, menthyl amide, simethicone, polyoxyethylene fatty alcohol ether Heat and mix, keep at 70°C for later use; (3) Preparation of water phase: heat and mix water, glycerin, sodium lauryl sulfate, and triethanolamine, keep at 70°C for later use; (4) Composite phase: under stirring conditions (speed 100-140r / min) to add the water phase to ...

Embodiment 2

[0042]

[0043] The preparation method of massage ointment comprises: (1) preparation of traditional Chinese medicine extract: get frankincense, myrrh, black medicine, chuanxiong, turmeric decoction pieces, add 2 times the amount of 85% ethanol of the decoction pieces, soak and extract 3 times, each 5 day, combine the extracts, add rue extract, belladonna liquid extract, stir well, filter, and adjust the relative density of the filtrate to 20 ℃ to be 0.80 for later use; (2) prepare the oil phase: stearic acid, monohard Glyceryl fatty acid, stearyl alcohol, methyl salicylate, menthol, peppermint oil, azone, camphor, clove oil, borneol, menthyl lactate, menthyl amide, simethicone, polyoxyethylene fatty alcohol ether heating Mix well and keep at 80°C for later use; (3) Preparation of water phase: heat and mix water, glycerin, sodium lauryl sulfate, and triethanolamine and keep at 80°C for later use; (4) Combine phases: under stirring conditions (speed 100~140r / min) to add the ...

Embodiment 3

[0054]

[0055] The preparation method of massage ointment comprises: (1) preparation of traditional Chinese medicine extract: get frankincense, myrrh, black medicine, chuanxiong, turmeric decoction pieces, add 1 times the amount of 90% ethanol of the decoction pieces, soak and extract 4 times, each 2 day, combine the extracts, add rue extract, belladonna liquid extract, stir well, filter, and adjust the relative density of the filtrate to 20 ℃ to be 0.80 for later use; (2) prepare the oil phase: stearic acid, monohard Glyceryl fatty acid, stearyl alcohol, methyl salicylate, menthol, peppermint oil, azone, camphor, clove oil, borneol, menthyl lactate, menthyl amide, simethicone, polyoxyethylene fatty alcohol ether heating Mix well and keep at 90°C for later use; (3) Preparation of water phase: heat and mix water, glycerin, sodium lauryl sulfate, and triethanolamine and keep at 90°C for later use; (4) Combine phases: under stirring conditions (the speed is 100~140r / min) to a...

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Abstract

The invention relates to a cool massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain. , menthol, peppermint oil, borneol, clove oil, and camphor are prepared from twelve traditional Chinese medicines. In addition, the present invention also relates to a preparation method of the cooling massage ointment, which mainly includes the following steps: (1) preparation of traditional Chinese medicine extract, (2) preparation of oil phase, (3) preparation of water phase and (4) synthesis. The massage ointment of the invention is more suitable for treating acute soft tissue injury. The massage ointment preparation method of the present invention has the characteristics of strong process operability, good product reproducibility, and high yield, and the massage ointment prepared by it has the characteristics of small emulsion particle size, uniform particle size distribution, and high transdermal absorption rate. The fuller characteristics of the medicinal effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain and a preparation method thereof. Background technique [0002] Acute soft tissue injury refers to the direct or indirect action of various external violence on the body, resulting in damage to the skin, subcutaneous tissue, fascia, muscle, tendon and ligament, periosteum, joint capsule, synovial bursa and other soft tissues, resulting in a series of pathological changes. disease. Its pathological changes are characterized by local acute inflammation and repair. The main clinical manifestations are local swelling, pain, functional impairment, bruising and ecchymosis. Acute soft tissue injury often causes fever due to stagnant blood stasis, resulting in intertwined blood stasis and heat. There is a pathogenesis of "blood stasis and fever". Therefore, in the treatment of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/9066A61P19/04A61P29/00A61K31/045A61K31/125A61K31/618
Inventor 倪永良杨宝翠刘铁军戎艳艳庞丽华陈光辉蔡向杰杨斯斯宋娜娜王娇高晗关秀伟
Owner SHINEWAY PHARMA GRP SHANDONG
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