Production technology for concentrating raw material extract of traditional Chinese medicine preparation of anti-inflammation and cholagogic tablet

Abstract

The invention relates to a production technology for concentrating a raw material extract for a traditional Chinese medicine preparation of an anti-inflammation and cholagogic tablet. According to the production technology, separating membranes with the selective active pharmaceutical ingredient retaining performance are used for performing membrane separation and concentration on the raw material extract under pressure, types of the separating membranes include ultrafiltration membranes, nanofiltration membranes and reverse osmosis membranes, and materials of the separating membranes include cellulose membranes, polysulfone membranes, polyamide membranes, ceramic membranes and the like. During membrane separation and concentration, the concentration of the extract is in a range of 0.1%-16% by the solid content, the operating temperature is in a range of 3 DEG C-80 DEG C, and the operating pressure is in a range of 0.1 MPa-6.0 MPa; and factors such as the extract concentration, the operating temperature, the operating pressure and the like can influence the permeation flux, and the permeation flux can be increased by reduction of the extract concentration, increase of the temperature and increase of the pressure. According to the production technology, heating is not required, no phase change occurs, the biological activity is not damaged, energy conservation and consumption reduction can be realized, the medicine quality can be improved, the production efficiency can be improved, and the production cost can be remarkably reduced.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and relates to a new process for concentrating raw material extracts during production of the traditional Chinese medicine preparation Xiaoyan Lidan Tablets. [0002] Background technique [0003] Xiaoyan Lidan Tablets, a traditional Chinese medicine preparation, is a traditional Chinese medicine commonly used clinically to treat acute cholecystitis and cholangitis; The conventional process for extracting and concentrating traditional Chinese medicines in enterprises is as follows: heat and reflux extraction with 10 to 12 times the amount of 80% to 85% ethanol for Andrographis paniculata and Bitterwood, each time for 2 hours, and recover the ethanol from the extract and concentrate it into an extract; Add 12-16 times the amount of drinking water to the yellow grass and decoct twice, each time for 2 hours, the extract is concentrated to a relative density of 1...

AI Technical Summary

Problems solved by technology

Since the concentration of the raw material extract is usually low, and the solid content is generally between 0.1% and 16%, the energy consumption in the subsequent stage of concentration by heating and evaporation is very large; and because the medicinal liquid is heated for a long time, it will lead to The degradation and destruction of active ingredients will also cause a large amount of extract to adhere to the inner wall of the tank and the inner wall of the pipeline, and even the extract is often scorched and denatured; the traditional method of concentrating traditional Chinese medicine extract has high energy consumption and low Low production efficiency, long production time, large solvent loss, low quality extracts, etc., low production efficiency, unstable drug quality, and high production costs

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