Preparation method of mesoporous silica spherical nano particles with dendritic pore structure

A technology of mesoporous silica and pore structure, applied in the directions of silica, silica, nanotechnology, etc., can solve the problems of complex synthesis method, high synthesis cost, lack of precise control of particle size, etc., and achieves simple preparation method, low cost synthesis

Active Publication Date: 2014-03-26
EAST CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The synthesis of dendritic mesoporous nanoparticles has made some progress. How to make full use of these multifunctional nanomaterials to replace or improve some existing nanomaterials with obvious defects or disadvantages requires more efforts, especially The precise control of particle size (20-200 nm) and the research on the formation mechanism are still quite lacking
In 2009, Japanese scientist Okuyama's research group first reported the synthesis of large-diameter dendritic mesoporous silica spherical particles using lysine (Lysine) as an a

Method used

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  • Preparation method of mesoporous silica spherical nano particles with dendritic pore structure
  • Preparation method of mesoporous silica spherical nano particles with dendritic pore structure
  • Preparation method of mesoporous silica spherical nano particles with dendritic pore structure

Examples

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Embodiment 1

[0025] First, 2.74g of cetyltrimethylammonium p-toluenesulfonate (CTATos) and 8.33g of F127 were added to 144ml of deionized water, 14.92g of triethanolamine (TEAH 3 ) in a beaker, stirred at 80°C for 1 hour until the solution became clear, then quickly added 20.83g of tetraethoxysilicate (TEOS) into the beaker, and continued to stir at 80°C for 2 hours to obtain a stable gel state suspension, the molar composition of the mixture is SiO 2 :CTATos:TEAH 3 :F127:H 2 O = 1:0.06:1:0.0095:80; the resulting mixture was centrifuged, washed, and dried to obtain mesoporous SiO with a dendritic pore structure 2 Nanoparticles, yield 65%, average particle size 50 nm. attached figure 1 and 2 It shows that the mesoporous SiO2 nanoparticles synthesized by this method have a uniform size and a specific surface area of ​​1300m 2 / g, the pore volume is 2.3ml / g, and the pore diameter is between 3 and 20nm; the pore has an obvious divergent pore structure from the inside to the outside, whic...

Embodiment 2

[0027] First, 2.74g of cetyltrimethylammonium p-toluenesulfonate (CTATos) was added to a solution containing 144ml of deionized water, 0.15g of triethanolamine (TEAH 3 ) in a beaker, stirred at 80°C for 1 hour until the solution became clear, then quickly added 20.83g of tetraethoxysilicate (TEOS) into the beaker, and after stirring for 30 minutes, added 8.33g of F127 into the mixed solution. Continue to stir at a constant temperature of 80°C for 1.5 hours to obtain a stable colloidal suspension. The molar composition of the mixture is SiO 2 :CTATos:TEAH 3 :F127:H 2 O=1:0.06:1:0.0095:80; the obtained mixture was centrifuged at high speed, washed, and dried to obtain mesoporous SiO2 nanoparticles with a dendritic pore structure of large particle size, with a yield of 73% and an average particle diameter of 120 nm ; specific surface area 1200m 2 / g, the pore volume is 1.8ml / g, and the pore diameter is between 3.1 and 20nm. image 3 and 4 .

Embodiment 3

[0029] Except that tetramethoxysilicate (TMOS) was used instead of tetraethoxysilicate (TEOS) in Example 1, other preparation conditions were the same as in Example 1, and the mesoporous SiO with dendritic pore structure was obtained. 2 The average particle size of nanoparticles is 30nm.

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Abstract

The invention discloses a preparation method of mesoporous silica spherical nano particles with a dendritic pore structure. A template agent adopted by the method is cetyltrimethyl p-methylbenzene ammonium sulfonate, an alkali source is organic small-molecular amine, and a silicon source is tetra-alkyl silicate ester; the added co-surfactant is a three-block neutral polymer F127; in the raw materials, the molar ratio of the silicon source to the template agent to organic small-molecular amine to F127 to water is 1:(0.03-0.06):(0.001-8.0):(0.0001-0.1):(20-1,000); the particle sizes of the particles can be effectively controlled from 20nm to 200nm. By simply controlling the addition amount of the co-surfactant F127 and the addition order before and after the silicon source, the particle size of the mesoporous silica with a dendritic pore structure can be effectively controlled. The synthesis method provided by the invention is simple and low in cost, has a short period and good repeatability, and is environment-friendly.

Description

technical field [0001] The invention relates to a preparation method of mesoporous molecular sieve, in particular to a preparation method of highly stable monodisperse mesoporous silicon dioxide spherical nanoparticles with dendritic pore structure. Background technique [0002] Dendrimers and polymer (Denderimer) materials have broad application prospects in medical fields such as targeted drug delivery, tissue engineering, gene transfer therapy, molecular imaging, and non-invasive surgery enhancement therapy. They are useful for early diagnosis and treatment of major diseases such as cancer. Efficient treatment is of great significance. However, due to the inherent poor thermal and chemical stability of the organic material carrier, the coated drug is prone to explosive release of the drug due to the decomposition of the organic carrier in the human body, and the organic carrier has the disadvantage of low drug coating . Inorganic nano-drug carriers with nano-pore struct...

Claims

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Application Information

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IPC IPC(8): C01B33/18B82Y30/00B82Y40/00
Inventor 张坤蒋金刚杨太群宋正芳虞叶骏刑俊玲马晓静
Owner EAST CHINA NORMAL UNIVERSITY
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