Hemostatic powder and preparation method thereof

Abstract

The invention relates to the technical field of biological medicines, in particular to a preparation method of hemostatic powder. The preparation method comprises the following steps: uniformly mixing chitosan extracted from an antarctic krill shell with an antimicrobial medicine in a mass ratio of (2-4): 1, sterilizing at 120 DEG C, and packaging. The invention further provides components and contents of the hemostatic powder. The chitosan extracted from the antarctic krill shell as a raw material is used as a main component of the hemostatic powder; and compared with ordinary chitosan, the chitosan extracted from the antarctic krill shell has a better hemostatic effect because a chitosan source is small in pollution, chitosan quality is greatly optimized and a raw material with high degree of deacetylation can be extracted.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a hemostatic powder using chitosan as one of its components and a preparation method thereof. Background technique [0002] Bleeding is one of the causes of death in trauma patients. Rapid and effective control of bleeding can significantly reduce the mortality rate. Simple surgery cannot completely control the bleeding, and the use of hemostatic materials can greatly reduce the amount of bleeding. At present, the local hemostatic materials widely used clinically mainly include powders (such as zeolite, collagen powder, and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose, and fibrin glue (such as instant gauze). ), hemostatic gauze, etc. [0003] These hemostatic materials have certain deficiencies: gelatin collagen material comes from cowhide, which is prone to allergies due to species differences and increases the infectio...

AI Technical Summary

Problems solved by technology

[0003] These hemostatic materials have certain deficiencies: gelatin collagen material comes from cowhide, which is prone to allergies due to species differences and increases the infection rate of wounds, especially for polluted wounds, so the application is limited; From the blood, it may cause virus infection; the structure of oxidized regenerated cellulose is loose, the adhesion to the bleeding point is poor, it may cause rebleeding, and the hemostasis time is longer, the effect on the rapid bleeding is poor, so it is not suitable as a wound alone Therefore, the application of hemostatic materials is limited; porous zeolite and potato starch will release a lot of heat after absorbing the water in the blood, leading to local necrosis of the wound, inflammation, etc.

However, the hemostatic effect of chitosan is related to its degree of deacetylation. It is difficult to extract high-quality medical chitosan from common sources such as shrimp shells and crab shells, which affects the hemostatic effect of chitosan.

[0005] The existing chitosan hemostatic powder has the following disadvantages: the source of raw materials is quite different. The raw material source of existing chitosan mainly comes from offshore shrimp shells and crab shells, and the waters where offshore crustaceans live are directly discharged into the sea by chemical plants. , waste water containing nitrogen and heavy metals, pesticides washed into the sea by rainwater on farmland and untreated domestic sewage pollution, causing great harm to human health

The existing chitosan is relatively low in quality and cannot meet the needs of high-quality medical chitosan