Hemostatic powder and preparation method thereof

A technology for hemostatic powder and production method, applied in the field of biomedicine, can solve the problems of increasing wound infection rate, long hemostasis time, domestic sewage pollution, etc., and achieve the effects of good hemostasis effect, optimized quality and less source pollution

Inactive Publication Date: 2014-04-02
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology

[0003] These hemostatic materials have certain deficiencies: gelatin collagen material comes from cowhide, which is prone to allergies due to species differences and increases the infection rate of wounds, especially for polluted wounds, so the application is limited; From the blood, it may cause virus infection; the structure of oxidized regenerated cellulose is loose, the adhesion to the bleeding point is poor, it may cause rebleeding, and the hemostasis time is longer, the effect on the rapid bleeding is poor, so it is not suitable as a wound alone Therefore, the application of hemostatic materials is limited; porous zeolite and potato starch will release a lot of heat after absorbing the water in the blood, leading to local necrosis of the wound, inflammation, etc.
However, the hemostatic effect of chitosan is re

Method used

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Embodiment Construction

[0025] The hemostatic powder of the present invention and its preparation method will be described in detail below.

[0026] The ingredients of this hemostatic powder are chitosan and antibacterial drugs extracted from Antarctic krill. The specific preparation method is as follows:

[0027] First, chitosan is extracted from Antarctic krill.

[0028] Step 1: Take 10 g of Antarctic krill shells, add 150 ml of 1 mol / L sodium hydroxide solution to boil for 1 hour, then wash with water until neutral, and obtain the first filter residue after solid-liquid separation.

[0029] Step 2: Soak the first filter residue in 100ml, 2mol / L hydrochloric acid solution at room temperature (23±2°C) for 1 hour, then wash with water until neutral, and obtain the second filter residue after solid-liquid separation.

[0030] Step 3: Boil the second filter residue in 100ml, 1mol / L sodium hydroxide solution for 1 hour, then wash with water until neutral, and obtain the third filter residue after solid...

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Abstract

The invention relates to the technical field of biological medicines, in particular to a preparation method of hemostatic powder. The preparation method comprises the following steps: uniformly mixing chitosan extracted from an antarctic krill shell with an antimicrobial medicine in a mass ratio of (2-4): 1, sterilizing at 120 DEG C, and packaging. The invention further provides components and contents of the hemostatic powder. The chitosan extracted from the antarctic krill shell as a raw material is used as a main component of the hemostatic powder; and compared with ordinary chitosan, the chitosan extracted from the antarctic krill shell has a better hemostatic effect because a chitosan source is small in pollution, chitosan quality is greatly optimized and a raw material with high degree of deacetylation can be extracted.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a hemostatic powder using chitosan as one of its components and a preparation method thereof. Background technique [0002] Bleeding is one of the causes of death in trauma patients. Rapid and effective control of bleeding can significantly reduce the mortality rate. Simple surgery cannot completely control the bleeding, and the use of hemostatic materials can greatly reduce the amount of bleeding. At present, the local hemostatic materials widely used clinically mainly include powders (such as zeolite, collagen powder, and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose, and fibrin glue (such as instant gauze). ), hemostatic gauze, etc. [0003] These hemostatic materials have certain deficiencies: gelatin collagen material comes from cowhide, which is prone to allergies due to species differences and increases the infectio...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/722C08B37/08A61P7/04A61P31/04
Inventor 赵晓丽吴帅黄卓瑶潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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