Tissue regeneration-guidable biomembrane and preparation method thereof

Abstract

The invention discloses a tissue regeneration-guidable biomembrane and a preparation method thereof. The tissue regeneration guidable biomembrane adopts a collagen membrane as a support, and adopts a natural three-dimensional space structure; the thickness of a protection layer formed by aluminium oxide or zirconium oxide granules arranged on one surface of the collagen membrane is 0.01-0.5 mum; the thickness of a hydroxyapatite strengthening layer arranged on the other surface of the collagen membrane is 0.01-0.1 mm. Compared with the tensile failure strength detection of the conventional pure collagen membrane, the mechanical strength of the biomembrane provided by the invention is raised by 7.5 times on average; animal reparation experiment effects have shown that the degradation time of the pure collagen membrane inside an animal body is 3-4 weeks, while the degradation time of the biomembrane provided by the invention inside the animal body can last for 12 weeks without collapsing; the biomembrane is fit closely on the reparation area through the strengthening layer without displacement and can ensure space for new tissues inside the animal body for a long period, and has good mechanical strength, can provide a good environment for growth of new bones to a greater extent, and the length of an newly-grown bone is the same as that of the original bone, so that an obviously optimal reparation effect compared with the pure collagen membrane is obtained.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering biomedical materials, and in particular relates to a biofilm capable of guiding tissue regeneration and a preparation method thereof. Background technique [0002] The biofilm that can guide tissue regeneration is mainly used for tissue regeneration when repairing tissue defects. It can be used as a physical barrier to prevent the surrounding tissue from growing into the defect area, and at the same time, it can be used as a protective film to protect the defect area and provide protection for the defect area. Allow space for tissue growth. [0003] Early guided tissue regeneration membranes were made of nonabsorbable materials (represented by polyethylene), which required secondary surgery to remove them, which added pain to patients. Subsequently, artificially synthesized absorbable materials (such as polylactic acid, aliphatic polyester and other degradable polymers) were developed....

AI Technical Summary

Problems solved by technology

Because chemical cross-linking will increase reagent residue, and physical cross-linking (such as thermal cross-linking) is difficult to achieve the ideal mechanical properties of the collagen film, so it still cannot solve the problem that the collagen film degrades too quickly and is prone to collapse

In Chinese patent application 201110145229.0, acetone is used to improve the density of the dense layer of the membrane, but the mechanical performance of the membrane cannot be solved.

There are clinical reports that due to the smooth surface of the membrane, membrane displacement occurs due to insufficient fixation of the membrane, leading to infection and ultimately treatment failure

Moreover, the membrane material should not be exposed to the external environment during use, otherwise it will lead to accelerated degradation of the material and increase the risk of infection of new tissue under the membrane

[0007] After searching, no report was found on technical measures to fully fit the membrane to the defect site. It was reported that multi-layer membrane coverage was used for prevention, which meant an increase in surgical costs and caused economic and psychological pressure on patients.

Images