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Absorbable orthopedic instrument material capable of prompting growth of bone tissues and preparation method thereof

A technology for bone tissue growth and orthopedics, which is applied in the field of orthopedic devices and can solve the problems of poor polarization effect and piezoelectric effect of piezoelectric ceramics, poor dielectric and electrical conductivity of polymers, and poor infiltration of piezoelectric ceramics and polymers. , to achieve high elastic modulus, improve stress sensitivity, polarization effect and good stress sensitivity

Inactive Publication Date: 2015-01-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, due to the poor dielectric and electrical properties of the polymer and the low elastic modulus, BaTiO 3 Piezoelectric ceramics have poor polarization and piezoelectric effects, and the weak electrical signals generated are not easily transmitted to body tissues; at the same time, BaTiO 3 Piezoelectric ceramics and polymers have poor wettability, and the interface bonding is not ideal. The addition of piezoelectric ceramics will deteriorate the unsatisfactory mechanical properties of this type of orthopedic device itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The selected biodegradable polymer is polylactic acid PLLA, and pure magnesium wire is used as the loaded BaTiO 3 The carrier and conductor of the piezoelectric ceramic functional film, the volume fraction is 25%, and the preparation process is as follows:

[0030] 1) Drawing pure magnesium into a wire with a diameter of 0.3mm;

[0031] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: at room temperature, weigh 0.25mol of Ba(OH) 2 ·8H 2 O dissolved in 170ml of CH 3 In COOH, heat to 70°C and stir vigorously, and cool to reflux for 1 hour at the same time, cool to room temperature, measure 85ml of tetrabutyl titanate, add 250ml of absolute ethanol, stir and cool quickly, add dropwise to the cooling reflux solution, and at the same time Stir vigorously for 20min to obtain BaTiO 3 Sol solution. Measure 200mL of colloidal solution and add it to 4L of micro-arc oxidation electrolyte. The main components of the electrolyte are 10g...

Embodiment 2

[0035] The degradable and absorbable polymer is selected as the copolymer PGLA of polylactic acid and polyglycolic acid, and the AZ31B magnesium alloy plate is used as the loaded BaTiO 3 The carrier and conductor of the piezoelectric ceramic film, the volume fraction is 40%, the preparation process is as follows:

[0036] 1) Hot rolling the magnesium alloy into a 0.5mm plate;

[0037] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: at room temperature, weigh 0.25mol of Ba(OH) 2 ·8H 2 O dissolved in 200 mL of CH 3 In COOH, heat to 70°C and stir vigorously, and cool to reflux for 2 hours at the same time, cool to room temperature, measure 85ml of tetrabutyl titanate, add 250ml of absolute ethanol, stir and cool quickly, add dropwise to the cooling reflux solution, and at the same time Stir vigorously for 30min to obtain BaTiO 3 Sol solution. Measure 200mL of colloidal solution and add it to 5L micro-arc oxidation electrolyte. The m...

Embodiment 3

[0041] The selected degradable absorbent polymer is polyglycolic acid (PGA), and QE22 magnesium alloy wire is used as the load BaTiO 3 The carrier and conductor of the piezoelectric ceramic functional film, the volume fraction is 30%, and the preparation process is as follows:

[0042] 1) Draw the magnesium alloy into a wire with a diameter of 0.5mm;

[0043] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: at room temperature, weigh 0.25mol of Ba(OH) 2 ·8H 2 O dissolved in 200 mL of CH 3 In COOH, heat to 70°C and stir vigorously, and cool to reflux for 2 hours at the same time, cool to room temperature, measure 100ml of tetrabutyl titanate, add 300ml of absolute ethanol, stir and cool quickly, then add dropwise to the cooling reflux solution, at the same time Stir vigorously for 30min to obtain BaTiO 3 Sol solution. Measure 300mL of colloidal solution and add it to 5L of micro-arc oxidation electrolyte. The main components of the...

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Abstract

The invention discloses an absorbable orthopedic instrument material capable of prompting growth of bone tissues and a preparation method thereof. The material is prepared by compounding a medical absorbable high-molecular polymer, a degradable pure magnesium or magnesium alloy which is loaded with BaTiO3 piezoelectric ceramics, can conduct piezoelectric signals and serves as a conductive carrier material, and grapheme for improving the electric polarization effect. When the absorbable orthopedic instrument material is in use, an electric signal produced by the piezoelectric ceramics under the action of an external load can be effectively conducted to organism tissues around an orthopedic instrument by the conductive carrier material to stimulate the growth of early hard tissues at a bone injury position and promote healing of the bone tissues. The BaTiO3 piezoelectric ceramics is loaded on the conductive carrier material through a dual loading technology consisting of electrophoresis-micro-arc oxidation and sol sealing, coating and film forming. Meanwhile, the conductive carrier material and the grapheme can also enhance the polarization effect and stress sensitivity of the piezoelectric ceramics. A bar material or a plate material is prepared firstly by means of a thermal die pressing, extruding or pulling method, and the orthopedic instrument is made by means of polarization and machining.

Description

technical field [0001] The invention relates to an absorbable orthopedic instrument with special functions and a preparation method thereof. During use, piezoelectric signals can be formed to promote fracture healing and bone tissue growth, belonging to the technical field of orthopedic instruments, specifically an absorbable orthopedic instrument for promoting bone tissue growth Orthopedic devices and methods of making the same. Background technique [0002] In recent years, orthopedic internal fixation devices such as absorbable bone screws and bone plates prepared by processing degradable polymer materials such as polylactic acid and polyglycolic acid have attracted more and more attention due to their advantages of degradability and small stress shielding effect. . However, when used as orthopedic instruments, they also have problems such as weak X-ray absorption ability and poor imaging effect. At the same time, they cannot generate electrical signals that can stimulat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61L31/18A61L31/02C25D13/02C25D15/00C25D11/30
Inventor 储成林李旋郭超白晶薛烽林萍华
Owner SOUTHEAST UNIV
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