Preparation method for microcapsules with magnetic nanoparticles-containing capsule walls

A technology of magnetic nanoparticles and microcapsules, which is applied in the field of biomedical materials, can solve the problems of complicated preparation process and affect the targetability of magnetic substances in drug efficacy, and achieve the effect of avoiding agglomeration, not easy to impurity, and achieving magnetic targeting ability.

Inactive Publication Date: 2014-04-23
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of magnetic microcapsules has been reported, either by introducing magnetic substances into the capsule wall by layer-by-layer self-assembly, or by directly embedding magnetic substances in the capsule core material by sonochemical methods. However, the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In 30ml of pH=6.0 phosphate buffer solution, 50mg Fe 3 o 4 Ultrasonic dispersion of nanoparticles; at N 2 Under protection, inject 5ml of a mixed solution of cysteine ​​with a concentration of 10mg / ml and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride with a concentration of 10mg / ml, without oxygen Under the condition of stirring and reacting for 12 hours, repeated adsorption and washing to remove unreacted cysteine, the obtained cysteine-Fe 3 o 4 Nanoparticles. 50mg prepared cysteine-Fe 3 o 4 Ultrasonic dispersion of nanoparticles in 25ml of deionized water; disperse 10mg of paclitaxel in 10ml of hydroxyl silicone oil; 3 o 4 The aqueous solution of nanoparticles and the hydroxyl silicone oil containing paclitaxel were placed in an ice-water bath; then the ultrasonic probe was placed at the oil / water two-phase interface, and ultrasonic irradiation was performed for 5 minutes at a power of 200W; the reaction solution was adsorbed several times and wa...

Embodiment 2

[0024] In 30ml of pH=6.0 phosphate buffer solution, 50mg Fe 3 o 4 Ultrasonic dispersion of nanoparticles; at N 2 Under protection, inject 5ml of a mixed solution of glutathione with a concentration of 10mg / ml and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride with a concentration of 10mg / ml, without oxygen Under the condition of stirring and reacting for 12 hours, repeated adsorption and washing to remove unreacted glutathione, the obtained glutathione-Fe 3 o 4 Nanoparticles. Glutathione-Fe prepared by 50mg 3 o 4 Ultrasonic dispersion of nanoparticles in 25ml of deionized water; disperse 10mg of paclitaxel in 10ml of hydroxyl silicone oil; 3 o 4 The aqueous solution of nanoparticles and the hydroxyl silicone oil containing paclitaxel were placed in an ice-water bath; then the ultrasonic probe was placed at the oil / water two-phase interface, and ultrasonic irradiation was performed for 5 minutes at a power of 200W; the reaction solution was adsorbed several ...

Embodiment 3

[0026] In 30ml of pH=6.0 phosphate buffer solution, 50mg of γ-Fe 2 o 3 Ultrasonic dispersion of nanoparticles; at N 2 Under protection, inject 5ml of a mixed solution of cysteine ​​with a concentration of 10mg / ml and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride with a concentration of 10mg / ml, without oxygen Under the condition of stirring and reacting for 12 hours, repeated adsorption and washing to remove unreacted cysteine, the obtained cysteine-γ-Fe 2 o 3 Nanoparticles. Cysteine-γ-Fe prepared by 50mg 2 o 3 Ultrasonic dispersion of nanoparticles in 25ml of deionized water; disperse 10mg of lomustine in 10ml of hydroxyl silicone oil; 2 o 3 The aqueous solution of nanoparticles and the hydroxyl silicone oil containing lomustine were placed in an ice-water bath; then the ultrasonic probe was placed at the oil / water two-phase interface, and ultrasonic irradiation was performed for 5 minutes at a power of 200W; the reaction solution was subjected to multipl...

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Abstract

The invention relates to a preparation method for microcapsules with magnetic nanoparticles-containing capsule walls. The microcapsules are medicine-carried microcapsules which take cross-linked films of sulfydryl-containing amino acid or peptide-modified magnetic nanoparticles as capsule walls and take an oil phase loaded with hydrophobic medicines as a core material. According to the preparation method, the magnetic nanoparticles are directly loaded on the capsule walls of the microcapsules, so that the agglomeration of the magnetic nanoparticles is avoided; the magnetic nanoparticles are uniformly distributed on the capsule walls of the microcapsules, so that the contact between the magnetic nanoparticles and the medicines loaded in capsule cores is reduced to the maximum; therefore, the influence on the medicine effect and the targeting caused by the magnetic nanoparticles is reduced; the controllable targeting transmission of the medicines is realized by utilizing the magnetic targeting of the magnetic nanoparticles; the controllable targeting release of the medicines is realized by utilizing the reduction responsiveness of disulfide bonds; the preparation method is easy to operate, efficient and quick, and moreover, impurities are not easily introduced.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a preparation method of a microcapsule whose capsule wall contains magnetic nanoparticles. Background technique [0002] Microcapsules are micro-containers or packages with a specific geometric structure composed of capsule-forming substances. Due to their special structure, variability in performance and wide range of applications, they are widely used in the fields of agriculture, food and biomedicine. Significant application. There are various materials for preparing microcapsules, mainly natural polymer materials (proteins, lipids, etc.) or synthetic polymer materials (PMMA, polylactic acid, etc.), or inorganic compounds (SiO 2 , CaCO 3 Wait). Among them, natural polymer materials have important application value in the preparation of microcapsules due to their good biocompatibility, non-toxicity and easy degradation. There are many methods for preparing microcapsules. According t...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/42A61K47/18A61K47/02
Inventor 崔学军李占锋高岩王洪艳
Owner JILIN UNIV
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