A kind of preparation method of self-gelling hydrogel freeze-dried powder

A technology of hydrogel and freeze-dried powder, which is applied in medical science, absorbent pads, bandages, etc. It can solve the problem of difficult gelation, damage to molecular structure and stability, and difficulty in completely removing residual components of small molecule monomer cross-linking agents. and other issues to achieve good biocompatibility

Active Publication Date: 2016-04-13
广东省科学院生物与医学工程研究所
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Problems solved by technology

[0003] There are many methods for preparing hydrogels, among which cross-linking by monomer polymerization is the most commonly used method. The disadvantage of this method is that residual components such as small molecule monomers, initiators, and cross-linking agents are difficult to completely remove.
The disadvantage of radiation crosslinking is that the molecular chain will be degraded during the irradiation process, which will destroy the molecular structure and stability. This technology has limitations for easily degradable polymer materials.
There are also literatures that point out that PVP with a molecular weight of not less than K-60 undergoes high-temperature and high-pressure ring-opening treatment to generate -COOH groups, and then reacts with chitosan to form a hydrogel through the hydrogen bond between the two molecules. It is difficult for polyvinylpyrrolidone to form a gel directly with chitosan without ring-opening treatment

Method used

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Examples

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preparation example Construction

[0023] A preparation method of a self-gelling hydrogel freeze-dried powder, comprising the following steps:

[0024] 1) chitosan is formulated into an aqueous solution to obtain solution A;

[0025] 2) dissolving polyvinylpyrrolidone or its copolymer in water to obtain solution B;

[0026] 3) Mix solution A and solution B, and let stand at room temperature for 10 to 20 days, or stand in vacuum for 3 to 5 days to obtain a gel-like system;

[0027] 4) Pre-freezing the gel-like system, freeze-drying, and grinding to obtain freeze-dried powder.

[0028] Preferably, in step 1), volatile acid is used to adjust the pH to 1-6, and the chitosan is dissolved in water to prepare solution A.

[0029] Preferably, in solution A, the concentration of chitosan is 0.01-0.04 g / mL.

[0030] Preferably, in solution B, the concentration of polyvinylpyrrolidone or its copolymer is 0.1-0.4 g / mL.

[0031] Preferably, the weight ratio of chitosan to polyvinylpyrrolidone or its copolymer is 1: (8-1...

Embodiment 1

[0040] 1) Disperse 2g of chitosan in 50mL of deionized water, add acetic acid dropwise under stirring conditions, adjust the pH to 6, and let it stand to obtain a clear and transparent aqueous solution, which is solution A;

[0041] 2) Under stirring conditions, dissolve 16g of polyvinylpyrrolidone (PVP-K30) in 160mL of deionized water to obtain a clear and transparent aqueous solution, which is solution B;

[0042] 3) Mix solution A and solution B, and let stand at room temperature for 14 days to obtain a gel-like system;

[0043] 4) The gel-like system was pre-frozen at -30°C for 10 hours, and then freeze-dried for 15 hours to obtain a light yellow brittle spongy solid, which was ground and pulverized to obtain a fine freeze-dried powder.

Embodiment 2

[0045] 1) Disperse 1 g of chitosan in 100 mL of deionized water, add hydrochloric acid dropwise under stirring conditions, adjust the pH to 3, and let stand to obtain a clear and transparent aqueous solution, which is solution A;

[0046] 2) Under stirring conditions, dissolve 15g of polyvinylpyrrolidone (PVP-K30) in 40mL of deionized water to obtain a clear and transparent aqueous solution, which is solution B;

[0047] 3) Mix solution A and solution B, and let stand at room temperature for 10 days to obtain a gel-like system;

[0048] 4) The gel-like system was pre-frozen at -20°C for 24 hours, and then freeze-dried for 10 hours to obtain a light yellow brittle spongy solid, which was ground and pulverized to obtain a fine freeze-dried powder.

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Abstract

The invention discloses a preparation method of hydrogel freeze-dried powder capable of self-gelling. The aqueous solution of chitosan is directly mixed with the aqueous solution of polyvinylpyrrolidone or its copolymer, and then left to stand for 10 to 20 days, or Under vacuum condition, stand still for 3-5 days, then freeze-dry and grind to obtain freeze-dried powder. The freeze-dried powder prepared by the method of the invention has good water absorption, and after absorbing water, it swells and coagulates rapidly to form a monolithic hydrogel. The freeze-dried powder is used for wounds and can play a role in hemostasis. Since the formed hydrogel is self-adaptive, the freeze-dried powder is suitable for complex-shaped wounds and cave-type wounds. The hydrogel freeze-dried powder prepared by the method of the invention has good biocompatibility because it does not contain components such as small molecular monomers, initiators, crosslinking agents, and has greater advantages as dressing materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a preparation method of self-gelling hydrogel freeze-dried powder. Background technique [0002] Hydrogel materials are a class of polymers with a three-dimensional network structure that have hydrophilic groups and are water-swellable but insoluble in water. Hydrogels can hold a large amount of water and are very soft, similar to biological tissues. They have good biocompatibility and can be directly used in human tissues, so they have broad application prospects in the field of biomedicine, such as wound dressings , drug carrier materials, medical coatings, cell culture substrates, anti-adhesion materials and the fixation of biological enzymes, etc. [0003] There are many methods for preparing hydrogels, among which crosslinking by monomer polymerization is the most commonly used method. The disadvantage of this method is that residual components such as small mole...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L39/06C08L5/08A61L15/24A61L15/28A61L15/42
Inventor 刘群峰陈军张佳泳许少波耿志杰张泽荣张锦
Owner 广东省科学院生物与医学工程研究所
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