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Corneal contact lens drug carrier with bionic characteristics, and preparation method thereof

A technology of contact lenses and characteristics, applied in medical science, surgery, etc., can solve the problems of limited drug loading and controlled release capabilities, and achieve the effect of improving hydrophilic performance, large social and economic benefits, and increased comfort

Active Publication Date: 2014-05-21
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because traditional hydrogel contact lenses also lack ligands that interact with drugs, their ability to load and control drug release is limited

Method used

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  • Corneal contact lens drug carrier with bionic characteristics, and preparation method thereof
  • Corneal contact lens drug carrier with bionic characteristics, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Add hydroxyethyl methacrylate (HEMA), cyclodextrin derivatives (the functionality of the double bond is 1.3) monomers into the container at a mass ratio of 1:1, and then add 1wt% MPC aqueous solution, wherein the mass of MPC 0.5% of the total mass of HEMA and cyclodextrin (M MPC :M HEMA+CD ); then add ammonium persulfate (APS), tetramethylethylenediamine (TMEDA) redox initiator with a molar ratio of 1:1, wherein the quality of the initiator is 0.5% of the total mass of HEMA and cyclodextrin derivatives (M APS+TMEDA :M HEMA+CD ); the whole system adds or maintains the mass content of solvent water to 35% (M Water :M 总体系 ). Stir the reaction system evenly and pour it into a mold, react at 60° C. for 1 hour, then soak in water for demoulding to obtain a terpolymer hydrogel. The equilibrium water content of the hydrogel is between 52% and 60%, the amount of adsorbed protein (BSA) is 6.8±0.3mg / g hydrogel, and the amount of drug loaded is 27±3.1mg / g. The drug release cu...

Embodiment 2

[0052] Add hydroxyethyl methacrylate (HEMA), cyclodextrin derivatives (the functionality of the double bond is 1.3) monomers into the container at a mass ratio of 4:1, and then add 1wt% MPC aqueous solution, wherein the mass of MPC 0.5% of the total mass of HEMA and cyclodextrin (M MPC :M HEMA+CD ); then add ammonium persulfate (APS), tetramethylethylenediamine (TMEDA) redox initiator with a molar ratio of 1:1, wherein the quality of the initiator is 0.5% of the total mass of HEMA and cyclodextrin derivatives (M APS+TMEDA :M HEMA+CD ); the whole system adds or maintains the mass content of solvent water to 35% (M Water :M 总体系 ). Stir the reaction system evenly and pour it into a mold, react at 60° C. for 1 hour, then soak in water for demoulding to obtain a terpolymer hydrogel. The equilibrium water content of the hydrogel is between 52% and 60%, the amount of adsorbed protein (BSA) is 7.0±0.2mg / g hydrogel, and the amount of drug loaded is 22±1.7mg / g. The drug release cu...

Embodiment 3

[0054] Add hydroxyethyl methacrylate (HEMA), cyclodextrin derivatives (the functionality of the double bond is 1.3) monomers into the container at a mass ratio of 9:1, and then add 1wt% MPC aqueous solution, wherein the mass of MPC 0.5% of the total mass of HEMA and cyclodextrin (M MPC :M HEMA+CD ); then add ammonium persulfate (APS), tetramethylethylenediamine (TMEDA) redox initiator with a molar ratio of 1:1, wherein the quality of the initiator is 0.5% of the total mass of HEMA and cyclodextrin derivatives (M APS+TMEDA :M HEMA+CD ); the whole system adds or maintains the mass content of solvent water to 35% (M Water :M 总体系 ). Stir the reaction system evenly and pour it into a mold, react at 60° C. for 1 hour, then soak in water for demoulding to obtain a terpolymer hydrogel. The equilibrium water content of the hydrogel is between 52% and 60%, the amount of adsorbed protein (BSA) is 7.1±0.3mg / g hydrogel, and the amount of drug loaded is 18±1.5mg / g. The drug release cu...

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Abstract

The invention discloses a corneal contact lens drug carrier with bionic characteristics. The carrier is formed by carrying out polymerization on a cyclodextrin derivative containing double bonds, phosphorylcholine, hydroxyethyl methacrylate and an initiator, wherein the average functionality of the double bonds in the cyclodextrin derivative containing the double bonds is 1.1-1.5; the mass of phosphorylcholine is 0.1-1% of the total mass of the cyclodextrin derivative containing the double bonds and hydroxyethyl methacrylate; the mass ratio of hydroxyethyl methacrylate to the cyclodextrin derivative containing the double bonds is (1-20): 1; the initiator comprises ammonia sulfate and tetramethyl ethylenediamine. The invention provides the novel corneal contact lens drug carrier with good oxygen permeation performance and drug controlled release capability; the obtained product is in accordance with the basic requirements of a corneal contact lens and is capable of controlling the release of eye ointment. The corneal contact lens drug carrier with bionic characteristics has higher social benefit and economic benefit.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to a drug carrier for corneal contact lenses with bionic properties and a preparation method thereof. Background technique [0002] The treatment of eye diseases is mainly done by drugs at present. In this process, too low drug concentration cannot play a therapeutic role; too high drug concentration will cause side effects and even damage normal tissues and organs. In addition, the therapeutic effect also depends on whether the drug can remain in the affected area for a sufficient time. Among the currently used ophthalmic preparations, more than 90% are eye drops or eye ointments, which stay in the eyes for only about 2 minutes, and only 1-7% of the drugs can be effectively utilized. Most of the drugs are discharged through the nasolacrimal duct or The nasal cavity enters the blood system, causing disadvantages such as inconvenient use, low utilization rate, and...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/04C08F290/10C08F220/28C08F4/40C08B37/16
Inventor 胡小红陈频马小涵王昕董岩
Owner JINLING INST OF TECH
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