Synthesis method for biphenyl compounds

A synthesis method and compound technology, which is applied in the field of synthesis of biphenyl compounds, can solve the problems of expensive, unstable ligands, and Pd cannot be recycled, and achieve the effects of low cost, simple recycling, and prevention of agglomeration
CN103804105AInactive Publication Date: 2014-05-21SHAOXING UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHAOXING UNIVERSITY
Publication Date
2014-05-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of organic synthesis, and discloses a synthesis method for biphenyl compounds. The method comprises the following steps: in the presence of an inorganic base, in a mixed solvent of ethanol and water, adding arylboronic acid, aryl halide and a heterogeneous catalyst ZrO2-Pd(OAc)2; reacting 30-180 min while the temperature is controlled at 60-120 DEG C; after reaction liquid is cooled to room temperature, filtering the reaction liquid, washing, and recovering the catalyst; adding a NaOH aqueous solution into filtrate, and carrying out extraction, drying and concentration on the obtained product so as to obtain a high-purity biphenyl compound. According to the invention, the heterogeneous catalyst ZrO2-Pd(OAc)2 which is high in catalytic activity and reusable is used for the first time, the quick coupling of aryl halide and arylboronic acid is realized by taking green and non-toxic ethanol and water as solvents under mild conditions, and then excessive arylboronic acid is removed by using the NaOH aqueous solution, so that the high-purity biphenyl compound is obtained. The method is good in catalytic effect, simple in operation, and environment-friendly.
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Description

technical field

[0001] The invention relates to the field of organic synthesis, in particular to a method for synthesizing biphenyl compounds. Background technique

[0002] Biphenyl compounds are a very important class of compounds, which are widely used in medicine, dyes, advanced functional materials and other fields. The development of green, low-cost and easy-to-operate synthetic methods is a research hotspot in organic synthesis. The Pd-catalyzed coupling reaction of halogenated aromatic hydrocarbons and arylboronic acids—Suzuki reaction is one of the effective methods for the synthesis of biphenyls. The classic Suzuki reaction uses palladium as a catalyst, and in the presence of ligands and bases, halogenated aromatic hydrocarbons and arylboronic acids are coupled in a homogeneous system to obtain biaryl compounds. Although the homogeneous Suzuki reaction has the advantages of high catalytic activity and good reaction selectivity, it has the disadvantages that the cat...

Claims

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