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Memantine hydrochloride preparation method

A technology of memantine hydrochloride and hydrochloric acid is applied in the preparation of organic compounds, the preparation of amino compounds, chemical instruments and methods, etc., and can solve the problems of instability, difficult post-processing, and excessively long reaction time.

Active Publication Date: 2014-06-04
SHANGHAI JINGXIN BIOLOGICAL MEDICAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] US5599998 reports the lithiation and ammoniation method, which requires the use of metal lithium, and the strong oxidizing, unstable toxic reagent chloramine. WO2010007351 discloses the Gabriel method, which has no advantages in reaction, difficult deprotection, and difficult post-processing. CN101768085 and other publications The nitrification reduction method is adopted, the nitrification reaction conditions are harsh, and the reaction time is too long
CN102050744 discloses a nitrogen trichloride-aluminum chloride method, which requires the use of highly toxic and explosive nitrogen trichloride, which is not suitable for selection and is difficult to industrialize

Method used

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  • Memantine hydrochloride preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Put 24 grams of 1-bromo-3,5-dimethyladamantane and 8 grams of methyl carbamate into a reaction bottle, add 50 ml of 98% formic acid, stir and dissolve at room temperature, protect with argon, and heat to 90°C for reaction 0.5 hours. Cool to room temperature, distill off formic acid under reduced pressure, then add 24 ml of concentrated hydrochloric acid, stir, heat to 90°C, and react for 3 hours. Cool to 25°C, crystals slowly precipitate out, and after the crystallization is complete, filter to obtain memantine hydrochloride.

[0044] GC purity: 99.5%, yield: 76%;

[0045] GC conditions: instrument Agilent 6960; column: Agilent HP-5; Int:340 o C; Det: 340 o C flow: 3.0 ml / min; GC purity: 99.8%;

[0046] MS(ESI): m / z = 180.2 [M+H + ];

[0047] 1 HNMR (400 MHz, CDCl 3 ):δ 0.793 (s, 6H), 1.161-1.064 (dd, 2H ), 1.283-1.279 (dd, 4H), 1.455-1.372 (dd,4H), 1.621-1.615 (d, 2H), 2.148-2.132 ( t,1H);

[0048] 13 C NMR (400MHz, CDCl 3): δ21.32 (CH3), 27.30 (CH2), 32.51...

Embodiment 2

[0050] Put 24 grams of 1-bromo-3,5-dimethyladamantane and 36 grams of ethyl carbamate into a reaction flask, add 240 ml of 98% formic acid, stir and dissolve at room temperature, protect with argon, and heat to 90°C for reaction 1 hour. Cool to room temperature, evaporate the formic acid under reduced pressure, then add 60 ml of hydrochloric acid with a mass concentration of 10%, stir, heat to 110°C, and react for 4 hours. After cooling to 0°C, crystals precipitate out. After the crystallization is complete, filter to obtain memantine hydrochloride.

[0051] GC purity: 99.0%, yield: 85%.

Embodiment 3

[0053] Put 24 grams of 1-bromo-3,5-dimethyladamantane and 15 grams of methyl carbamate into a reaction flask, add 100 ml of 88% formic acid, stir and dissolve at room temperature, protect with argon, and heat to 140°C for reaction 1.5 hours. Cool to room temperature, evaporate formic acid under reduced pressure, then add 50 ml of 20% hydrochloric acid, stir, heat to 105°C, and react for 3 hours. After cooling to 5°C, crystals precipitate out. After the crystallization is complete, filter to obtain memantine hydrochloride.

[0054] GC purity: 99.2%, yield: 79%.

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Abstract

The present invention discloses a memantine hydrochloride preparation method, which is characterized by comprising: A, adopting formic acid as a solvent, and carrying out a reaction of carbamate and a compound II for 0.25-4 h at a temperature of 50-150 DEG C to obtain a mixture a; and B, evaporating the mixture a to remove the formic acid, adding hydrochloric acid, carrying out hydrolysis for 0.5-10 h at a temperature of 40-110 DEG C, carrying out cooling crystallization at a temperature of -5-30 DEG C, and filtering to obtain the memantine hydrochloride, wherein the carbamate is as the follow, the compound II is 1-bromo-3,4-dimethyl adamantane, and R is methyl or ethyl. According to the present invention, the carbamate and the compound II are adopted as the raw materials without use of toxic, harmful and hazardous raw materials; the carbamate is adopted as the amino source in the reaction, such that the reaction can be performed in the rapid, homogeneous-phase and stable manner; and characteristics of simple reaction condition, low reaction temperature, short reaction time, high final product collection rate and low cost are provided.

Description

technical field [0001] The invention relates to a preparation method of memantine hydrochloride, which belongs to the field of medicine preparation. Background technique [0002] 3,5-Dimethyl-1-amantadine hydrochloride (Memantine hydrochloride), CAS No. 41100-52-1, has the following structure: [0003] [0004] Its free amine form, 3,5-dimethyl-1-adamantanamine, has a CAS number of 19982-08-2 and has the following structure: [0005] [0006] Memantine hydrochloride is a non-competitive NMDA (N-methyl-D-aspartate) receptor antagonist. The drug is the first drug with significant efficacy in the treatment of AD and vascular dementia, and the only NMDA antagonist developed for Alzheimer's disease. [0007] There are currently several methods of preparing memantine hydrochloride: [0008] Ritter method; [0009] US3391142 discloses the Ritter method of synthesizing memantine hydrochloride and its intermediate 1-acetylamino-3,5-dimethyladamantane. A large amount (17 mol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C211/38C07C209/62
Inventor 黄悦郑飞
Owner SHANGHAI JINGXIN BIOLOGICAL MEDICAL
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