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Method for preparing lipid-lowering chewable tablet of four leaves

A technology of chewable tablets and lotus leaves, which is applied in the field of preparation of lipid-lowering and weight-loss drugs, can solve the problems of affecting lipid-lowering activity, leaching out many impurities, and difficulty in extracting active ingredients, etc., and achieve the effect of reducing body weight, increasing the beauty of pigment, and moderate hardness

Inactive Publication Date: 2014-06-25
ANHUI XINHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current application of four medicines in reducing blood lipids is mainly based on brewing tea, and more impurities are dissolved out, which affects the lipid-lowering activity; on the other hand, a certain preparation is prepared by traditional extraction. Mainly, affected by solvent and high temperature, it is difficult to extract high-purity active ingredients

Method used

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  • Method for preparing lipid-lowering chewable tablet of four leaves
  • Method for preparing lipid-lowering chewable tablet of four leaves
  • Method for preparing lipid-lowering chewable tablet of four leaves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] 1) After drying, 52 mass parts of lotus leaves, 12 mass parts of mulberry leaves, 21 mass parts of ginkgo leaves and 35 mass parts of chrysanthemum leaves are pulverized and passed through a 24-mesh sieve to obtain powder a. The extract was obtained by critical carbon dioxide extraction, refrigerated at 4°C for 10 hours, suction filtered, the filtrate recovered ethanol, added an equal volume of petroleum ether and water, extracted 4 times, the water layer was concentrated under reduced pressure and dried in vacuo to obtain a dry extract; supercritical The process parameters of carbon dioxide extraction are: extraction time 120min, extraction temperature 45°C, CO 2 The flow rate is 16L / h, the entrainer is 100ml of 95vt% ethanol, the separation pressure is 6MPa, and the separation temperature is 35°C.

[0013] 2) Dried the lotus leaves and pulverized them with a superfine pulverizer, and passed through a 300-mesh sieve to obtain lotus leaf superfine powder;

[0014] 3) P...

Embodiment 2

[0016] 1) After drying, 52 mass parts of lotus leaves, 12 mass parts of mulberry leaves, 21 mass parts of ginkgo leaves and 35 mass parts of chrysanthemum leaves are pulverized and passed through a 24-mesh sieve to obtain powder a. The extract was obtained by critical carbon dioxide extraction, refrigerated at 2°C for 8 hours, suction filtered, the filtrate recovered ethanol, added an equal volume of petroleum ether and water, extracted 5 times, the water layer was concentrated under reduced pressure and dried in vacuo to obtain a dry extract; supercritical The process parameters of carbon dioxide extraction are: extraction time 130min, extraction temperature 50°C, CO 2 The flow rate is 17L / h, the entrainer is 150ml of 95vt% ethanol, the separation pressure is 6MPa, and the separation temperature is 35°C.

[0017] 2) Dried the lotus leaves and pulverized them with a superfine pulverizer, and passed through a 300-mesh sieve to obtain lotus leaf superfine powder;

[0018] 3) Pu...

Embodiment 3

[0020] 1) After drying, 52 mass parts of lotus leaves, 12 mass parts of mulberry leaves, 21 mass parts of ginkgo leaves and 35 mass parts of chrysanthemum leaves are pulverized and passed through a 24-mesh sieve to obtain powder a. The extract was obtained by critical carbon dioxide extraction, refrigerated at 5°C for 12 hours, suction filtered, the filtrate recovered ethanol, added an equal volume of petroleum ether and water, extracted 4 times, the water layer was concentrated under reduced pressure and dried in vacuo to obtain a dry extract; supercritical The process parameters of carbon dioxide extraction are: extraction time 140min, extraction temperature 55°C, CO 2 The flow rate is 18L / h, the entrainer is 200ml of 95vt% ethanol, the separation pressure is 6MPa, and the separation temperature is 35°C.

[0021] 2) Dried the lotus leaves and pulverized them with a superfine pulverizer, and passed through a 300-mesh sieve to obtain lotus leaf superfine powder;

[0022] 3) P...

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Abstract

The invention discloses a method for preparing a lipid-lowering chewable tablet of four leaves. The method comprises the following steps: firstly, crushing lotus leaf, folium mori, ginkgo leaf and chrysanthemum leaf to obtain powder a; carrying out supercritical CO2 extraction on the powder a to obtain an extract solution; refrigerating at 0-5 DEG C for 12 hours; carrying out suction filtration, extraction, vacuum concentration and vacuum drying to obtain a dry extract; crushing to obtain extract powder; then drying the lotus leaf and smashing by using an ultrafine grinder to obtain lotus leaf superfine powder; putting skim milk powder and microcrystalline cellulose into a mortar to grind and evenly mix, so as to obtain powder b; evenly mixing the extract powder with the powder b; adding the lotus leaf superfine powder, and evenly mixing to obtain a mixture; adding polyvinylpyrrolidone to the mixture to prepare a soft material; adding superfine silica powder after pelletizing and straightening, and then tabletting, so as to obtain the lipid-lowering chewable tablet of the four leaves. The lipid-lowering chewable tablet of the four leaves disclosed by the invention can be used for effectively reducing the weight, the fat and the liver weight of mice, and has latent effects of reducing weight and lowering lipid.

Description

1. Technical field [0001] The invention relates to a preparation method of a lipid-lowering and weight-reducing drug, in particular to a preparation method of a four-leaf lipid-lowering chewable tablet. 2. Background technology [0002] The formula of Four Leaf Chewable Tablets is derived from the addition and subtraction formula of Xianmei Slimming Tea. Chrysanthemum leaves and lotus leaves are selected in the formula, and mulberry leaves and ginkgo leaves are added to form this formula. The lotus leaf in the prescription is the main medicine, and the other three medicines are supplementary medicines. The four leaves are both medicinal and edible medicinal materials, mainly containing flavonoids. [0003] The lotus leaf in the prescription is the dried leaf of the lotus (Nelumbo nucifera Gaertn), a plant of the water lily family. The flavonoids of the lotus leaf have the functions of reducing fat and losing weight, resisting free radicals, antioxidation, antibacterial, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A23L1/29A61K9/20A61P3/06A61P3/04A23L33/00
Inventor 卫强杨春燕尹伟戴一张国升甘艳娇陆灿杨淑芹
Owner ANHUI XINHUA UNIV
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