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Lincomycin hydrochloride gel and preparation process thereof

A technology of lidocaine gel and lincomycin, which is applied in the direction of anesthetics, aerosol delivery, and medical preparations containing active ingredients, etc., can solve problems such as the decrease of skin penetration rate, and achieve improved drug efficacy and preparation The process is simple and the effect of improving the transdermal penetration rate

Inactive Publication Date: 2014-07-09
王敦亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, menthol is easy to sublimate, and high temperature needs to be avoided, so after long-term or accelerated inspection of lidocaine gel, the skin penetration rate decreases

Method used

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  • Lincomycin hydrochloride gel and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Lincomycin-Lidocaine Gel

[0037] Lincomycin Hydrochloride 0.5%

[0038] Lidocaine Hydrochloride 0.4%

[0039] Macrogol Glyceride Oleate 5.8%

[0040] Caprylic Capric Triglyceride 20%

[0041] Caprylic Capric Macrogol Glycerides 20%

[0042] 5% xanthan gum aqueous solution balance.

[0043] Preparation Process:

[0044] (1) Add lincomycin hydrochloride and lidocaine hydrochloride to 5% (W / V) xanthan gum aqueous solution, stir to dissolve, and obtain a clear solution, which is used as the water phase for later use;

[0045] (2) Weigh oleic acid macrogol glyceride and caprylic capric acid triglyceride, add caprylic acid capric acid macrogol glyceride, stir to obtain a clear solution, and use it as the oil phase for later use;

[0046] (3) Add the oil phase to the water phase, and stir evenly to obtain lincomycin lidocaine gel.

Embodiment 2

[0047] Example 2 Preparation of Lincomycin-Lidocaine Gel

[0048] Lincomycin Hydrochloride 0.5%

[0049] Lidocaine Hydrochloride 0.4%

[0050] Macrogol Glyceride Oleate 13.1%

[0051] Caprylic Capric Triglyceride 27%

[0052] Caprylic Capric Macrogol Glycerides 30%

[0053] 10% xanthan gum aqueous solution balance.

[0054] Preparation Process:

[0055] (1) Add lincomycin hydrochloride and lidocaine hydrochloride to 10% (W / V) xanthan gum aqueous solution, stir to dissolve, and obtain a clear solution, which is used as the water phase for later use;

[0056] (2) Weigh oleic acid macrogol glyceride and caprylic capric acid triglyceride, add caprylic acid capric acid macrogol glyceride, stir to obtain a clear solution, and use it as the oil phase for later use;

[0057] (3) Add the oil phase to the water phase, and stir evenly to obtain lincomycin lidocaine gel.

Embodiment 3

[0058] Example 3 Preparation of Lincomycin-Lidocaine Gel

[0059] Lincomycin Hydrochloride 0.5%

[0060] Lidocaine Hydrochloride 0.4%

[0061] Macrogol Glyceride Oleate 10%

[0062] Caprylic Capric Triglyceride 18%

[0063] Caprylic Capric Macrogol Glycerides 24%

[0064] 7% xanthan gum aqueous solution balance.

[0065] (1) Add lincomycin hydrochloride and lidocaine hydrochloride to 7% (W / V) xanthan gum aqueous solution, stir to dissolve, and obtain a clear solution, which is used as the water phase for later use;

[0066] (2) Weigh oleic acid macrogol glyceride and caprylic capric acid triglyceride, add caprylic acid capric acid macrogol glyceride, stir to obtain a clear solution, and use it as the oil phase for later use;

[0067] (3) Add the oil phase to the water phase, and stir evenly to obtain lincomycin lidocaine gel.

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Abstract

The invention discloses lincomycin hydrochloride gel and a preparation process thereof. Lincomycin hydrochloride and lidocaine hydrochloride are used as main drugs of the gel, oleic macrogolglyceride is used as a permeation enhancer, caprylic capric triglyceride is used as a surfactant, and octanoate decanoate macrogolglyceride is used as an oil solvent. The preparation process of the preparation disclosed by the invention is simple, no special storage condition is needed, the product stability is good, and more importantly, the transdermal permeability of the lidocaine hydrochloride is improved, so as to further improve the efficacy.

Description

[0001] technical field [0002] The invention belongs to the technical field of pharmaceutical preparations, in particular to an external pharmaceutical preparation containing lincomycin hydrochloride and lidocaine hydrochloride. [0003] Background technique [0004] Lincomycin lidocaine gel is used for various skin infections caused by minor burns, wounds and mosquito bites. Lincomycin hydrochloride (lincomycin) is an antibiotic with a similar antibacterial spectrum to erythromycin. It mainly has high antibacterial activity against Gram-positive bacteria, and its mechanism of action is to inhibit bacterial protein synthesis. Lidocaine, as a local anesthetic, has analgesic and antipruritic effects for external use; lidocaine hydrochloride is a commonly used amide local anesthetic in clinical practice. [0005] The gel is a transdermal preparation, and the transdermal accelerators used mainly include azone, propylene glycol, urea, and menthol. But above-mentioned transde...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/06A61P31/04A61P23/00A61K31/167
Inventor 张德芳
Owner 王敦亮
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