Method used for taking pollen and triblock copolymer as templates for synthesizing of mesoporous silica microspheres

A technology of mesoporous silica and copolymers, which is applied in the directions of silica, silica, medical preparations with inactive ingredients, etc. Ability, effect of large-scale industrial promotion value

Inactive Publication Date: 2014-07-09
RES INST OF XIANGCHENG SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Search patents, although some patents disclose the method of preparing mesoporous silica microspheres by composite template method, but the above method has certain shortcomings, and the template selection is not cheap and easy to obtain

Method used

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  • Method used for taking pollen and triblock copolymer as templates for synthesizing of mesoporous silica microspheres
  • Method used for taking pollen and triblock copolymer as templates for synthesizing of mesoporous silica microspheres
  • Method used for taking pollen and triblock copolymer as templates for synthesizing of mesoporous silica microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Synthesis process of mesoporous silica microspheres:

[0034] (1) Clean rapeseed pollen with ethanol ultrasonically for 3 times, take it out, rinse it repeatedly with ethanol and water and dry it;

[0035] (2) Add 1 g of triblock copolymer P123 and 5 g of hydrochloric acid solution with a concentration of 2 mol / L into 95 g of deionized water, stir to dissolve, add 1 g of rapeseed pollen, stir for 1 day, then add 2.08 g of ethyl orthosilicate, Stir in a water bath at 40°C for 3 days;

[0036] (3) The impregnated product is taken out, washed and dried in sequence, and the washing can be done by first washing with absolute ethanol aqueous solution, and then washing with deionized water. Calcined at 550° C. for 3 hours, cooled naturally to obtain mesoporous silica microspheres.

[0037] The resulting mesoporous silica microspheres were characterized as follows:

[0038] Such as figure 1 shown, from figure 1 It can be seen that the material is a spherical shape with r...

Embodiment 2

[0043] Synthesis process of mesoporous silica microspheres:

[0044] (1) Ultrasonic cleaning of camellia powder with ethanol for 3 times, after taking it out, rinse it with ethanol and water repeatedly and dry it;

[0045] (2) Add 2 g of triblock copolymer P123 and 8 g of hydrochloric acid solution with a concentration of 2 mol / L into 110 g of deionized water, stir to dissolve, add 1.5 g of camellia powder, stir for 3 days, then add 3 g of tetraethyl orthosilicate, Stir in a water bath at 40°C for 3 days;

[0046] (3) Take out the impregnated product, wash and dry in sequence. The cleaning can be done by first washing with anhydrous ethanol aqueous solution, then washing with deionized water, calcining at 700°C for 3 hours, taking out after natural cooling to obtain mesoporous silica Microspheres.

[0047] The mesoporous silica microspheres prepared by the above method are shown in Figure 4 , it can be seen that the diameter of a single ball is about 15 μm, there is basica...

Embodiment 3

[0049] Synthesis process of mesoporous silica microspheres:

[0050] (1) Clean rapeseed pollen with ethanol ultrasonically for 3 times, take it out, rinse it repeatedly with ethanol and water and dry it;

[0051] (2) Add 2 g of triblock copolymer F127 and 10 g of hydrochloric acid solution with a concentration of 2 mol / L into 120 g of deionized water, stir to dissolve, add 2 g of rapeseed pollen, stir for 1 day, add 4 g of tetraethyl orthosilicate, 40 Stir in a water bath for 1 day;

[0052] (3) Take out the impregnated product, wash and dry in sequence. The cleaning can be washed with anhydrous ethanol aqueous solution first, then washed with deionized water, calcined at 600°C for 5 hours, and taken out after natural cooling to obtain mesoporous silica Microspheres.

[0053] The mesoporous silica microspheres prepared by the above method are shown in Figure 5 , it can be seen that the diameter of a single sphere is about 12 μm, there is basically no breakage and agglomera...

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Abstract

The invention discloses a method used for taking pollen and a triblock copolymer as templates for synthesizing of mesoporous silica microspheres. The method comprises following steps: (1) pollen are washed and dried in the air; (2) the triblock copolymer and hydrochloric acid solution are added into water, an obtained mixture is stirred for dissolving, pollen is added, an obtained mixed material is stirred continuously, ethyl orthosilicate is added, and an obtained material is subjected to water bath, and is stirred again; (3) a product obtained via dipping is collected, and is subjected to cleaning, drying, roasting, and natural cooling so as to obtain the mesoporous silica microspheres. The mesoporous silica microspheres prepared via the method possesses nano-grade mesoporous channels, and micron-grade hollow capsule structures. The micron-grade hollow capsule structures of the mesoporous silica microspheres are capable of providing medicines with large storage space; outer wall mesoporous structures can be used as delivering channels for the medicines; and slow release effect is realized. According to the method, double-template method is adopted, the required biotemplate and the required polymer template are easy to remove, no pollution is caused to the environment; no complex equipment is needed for reaction; the method is simple and convenient; experimental repeatability is high; and industrial popularization value is relatively high.

Description

technical field [0001] The invention belongs to the technical field of synthesis methods of mesoporous materials, in particular to a method for synthesizing mesoporous silicon oxide microspheres using pollen and tri-block copolymers as templates. Background technique [0002] Drug embedding and controlled release has always been one of the difficult problems in biomedicine and material science research. In recent years, ordered porous materials, especially mesoporous materials, have become a research hotspot as carriers for drug embedding and controlled release. However, the traditional mesoporous silica still has great limitations in practical applications due to its single pore structure and limited pore volume. Therefore, a considerable number of researchers are devoted to the development of ordered porous SiO with special morphology and structure. 2 materials in order to obtain better drug loading capacity and release effect. Among them, SiO with a hollow thin shell s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/12A61K47/04
Inventor 陈志刚陈丰吴正颖刘成宝陆秋月王赛
Owner RES INST OF XIANGCHENG SUZHOU UNIV OF SCI & TECH
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