Kelp-amino composite tablet for lowering content of uric acid and preparation method thereof

The technology of kelp amino group and compound tablet is applied in the field of biotechnology preparation, which can solve the problems of tolerance damage to the kidney, obvious side effects, etc., and achieve the effect of simple synthesis, obvious effect and reducing uric acid.

Active Publication Date: 2014-07-16
QINGDAO KUNBU BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of Western medicines that lower uric acid has obvious side effects, and long-term use of medicines by patients will cause tolerance, or in turn damage the function of the kidneys

Method used

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  • Kelp-amino composite tablet for lowering content of uric acid and preparation method thereof
  • Kelp-amino composite tablet for lowering content of uric acid and preparation method thereof
  • Kelp-amino composite tablet for lowering content of uric acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kelp amino compound tablet for reducing uric acid content, including kelp extract, short peptide, vitamin C and auxiliary materials, the weight ratio of the four is 1:1:1:0.5.

[0040] The auxiliary materials include folic acid, white rake tooth fungus and hawthorn, and their weight ratio is 0.01:1:1:1.

[0041] The preparation method of above-mentioned composite sheet, comprises the following steps:

[0042] (1) Preparation of kelp extract: kelp with a wet weight of 1000kg, put in a large seawater steamer at 80-90 degrees for 1 minute, take out the kelp, cool the seawater, add neutral potassium salt equivalent to 40% of the wet weight of kelp, After marinating for 24 hours, as the temperature and salinity in the water increase, the kelp cell wall will shrink violently and secrete a large amount of body fluids. The centrifuge dehydrates to obtain 300 liters of liquid containing kelp extract, and then adds water and alcohol to precipitate to obtain kelp extract.

[00...

Embodiment 2

[0045] Embodiment 2 Animal experiments

[0046] Experiment (1): 6 female rats (8 weeks, body weight 180g) per group; the composite sheet in Example 1.

[0047] Adding adenine with a concentration of 0.75% in the feed will cause uric acid excretion disorder in the kidneys of rats, resulting in hyperuricemia.

[0048] Add 0.75% adenine to the feed of the control group, and the input dose is 1 mg / kg, and add 0.75% adenine to the compound tablet.

[0049] Blood uric acid was tested on the first day and 24 days after the start of the experiment. The blood uric acid in the control group was 0.57 mg / ml on the first day and 2.33 mg / ml after 24 days. Correspondingly, the blood uric acid in the administration group was 0.67 mg / ml on the 24th. It can be seen that the effect of the composite sheet is obvious.

[0050] experiment (2)

[0051] Rats in the experimental group were fed with drugs: Adenine, lot number 000606 was purchased from Sigama Company; ethambutol tablets (Ethambutol)...

Embodiment 3

[0053] Embodiment 3 human body test

[0054] experiment (1)

[0055] The experimental population consisted of 14 people, 8 males aged 50-60, 3 males aged 60-70, and 3 females aged 55-65. All patients with high uric acid take 700mg of kelp compound tablets every day, see figure 2 :

[0056] Experimental conclusion: Kelp compound tablet has obvious effect on reducing uric acid.

[0057] experiment (2)

[0058] Organize people with high uric acid to take kelp, amino, and vitamin C compound tablets for 3 months to see the effect image 3 , the same effect is obvious.

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PUM

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Abstract

The invention discloses a kelp-amino composite tablet for lowering content of uric acid and a preparation method thereof. The composite tablet comprises a kelp extract, a nutrient with amino and vitamin C in a weight ratio of 1:(0.5-1.5):(0.5-1.5). The preparation method of the composite tablet comprises the following steps of: (1), preparing the kelp extract: adding 1000kg (based on wet weight) of the kelps and seawater of 80-90 DEG C into a large steaming pot for one minute, cooling the seawater after taking out the kelps, adding neutral potassium salt which accounts for 20%-60% of the wet kelps, salting for 24 hours, centrifuging by a centrifugal machine to obtain 300 L of liquid containing the kelp extract, and then adding water and alcohol to precipitate to obtain the kelp extract; (2), adding the nutrient with the amino into the kelp extract prepared in the step (1); (3), adding vitamin C and pressing into the composite sugar tablet. The composite tablet disclosed by the invention is simple in extracting process and concise in synthesis. The product is synthesized by pure natural food, free of side effect and obvious in effect for lowering uric acid.

Description

technical field [0001] The invention relates to a kelp amino compound tablet for reducing uric acid content and a preparation method thereof, belonging to the field of biotechnology preparation. Background technique [0002] Gout is a group of diseases caused by the increase of uric acid production and / or the decrease of uric acid excretion caused by the disorder of purine metabolism. Modern medicine has made it clear that the onset of gout is directly related to the increase of uric acid concentration in the blood caused by the disorder of purine metabolism in the body. A serious metabolic disease of health. Gouty arthritis is due to the increase of uric acid in the body, resulting in the deposition of urate in the joint capsule, synovium, cartilage, bone or / and accompanied by urate deposition in the kidney, subcutaneous, and other tissues, causing tissue damage and inflammation. Elevated blood uric acid is an important feature of gouty arthritis. [0003] With the improv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K36/02A23L1/29A61K9/20A61K47/22A61P19/06A61K31/195A23L33/00
Inventor 赵英伟赵基恩徐祖洪
Owner QINGDAO KUNBU BIOLOGICAL ENG
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