Injection type directional sustained-release paeonol thermosensitive gel and its preparation method

A phenol temperature-sensitive gel and injection-type technology, which is applied in the field of injection-type sustained-release paeonol temperature-sensitive gel and its preparation, can solve problems such as the inability to guarantee long-term effective drug concentration at the patient site, and achieve long-lasting drug effects

Inactive Publication Date: 2014-07-23
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the paeonol injection in the prior art cannot guarantee the long-term effective concentration of the drug at the affected part, the present invention provides an injection-type directional slow-release paeonol temperature-sensitive gel and a preparation method thereof. Quickly dissolves in water-based solution at 40°C to form an injectable mix...

Method used

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  • Injection type directional sustained-release paeonol thermosensitive gel and its preparation method
  • Injection type directional sustained-release paeonol thermosensitive gel and its preparation method
  • Injection type directional sustained-release paeonol thermosensitive gel and its preparation method

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Embodiment 1

[0025] An injection-type directional sustained-release paeonol temperature-sensitive gel is formed by dissolving paeonol in a water-based solution and solidifying it. The water-based solution is composed of chitosan, sodium β-glycerophosphate, hydrochloric acid solution, and sodium hydroxide solution. Prepared with deionized water, wherein the ratio of chitosan, β-sodium glycerophosphate, hydrochloric acid solution and deionized water is 85mg: 0.45ml: 450mg: 0.45ml;

[0026] The ratio of paeonol to the water-based solution is that 1 g of paeonol is added to every 99 g of the water-based solution, that is, the mass percentage of paeonol in the cured composite hydrogel is 1%.

[0027] The preparation method of the above-mentioned injection-type directional slow-release paeonol thermosensitive gel comprises the following steps:

[0028] 1) Weigh chitosan, sodium β-glycerophosphate, hydrochloric acid solution, sodium hydroxide solution and deionized water according to the above ra...

Embodiment 2

[0047] An injection-type directional sustained-release paeonol temperature-sensitive gel is formed by dissolving paeonol in a water-based solution and solidifying it. The water-based solution is composed of chitosan, sodium β-glycerophosphate, hydrochloric acid solution, and sodium hydroxide solution. Prepared with deionized water, wherein the ratio of chitosan, β-sodium glycerophosphate, hydrochloric acid solution and deionized water is 90mg: 0.5ml: 500mg: 0.5ml;

[0048] The ratio of paeonol to the water-based solution is that 1.5 g of paeonol is added to every 98.5 g of the water-based solution, that is, the mass percentage of paeonol in the cured composite hydrogel is 1.5%.

[0049] The preparation method of the above-mentioned injection-type directional slow-release paeonol thermosensitive gel comprises the following steps:

[0050] 1) Weigh chitosan, sodium β-glycerophosphate, hydrochloric acid solution, sodium hydroxide solution and deionized water according to the abov...

Embodiment 3

[0058] An injection-type directional sustained-release paeonol temperature-sensitive gel is formed by dissolving paeonol in a water-based solution and solidifying it. The water-based solution is composed of chitosan, sodium β-glycerophosphate, hydrochloric acid solution, and sodium hydroxide solution. Prepared with deionized water, wherein the ratio of chitosan, β-sodium glycerophosphate, hydrochloric acid solution and deionized water is 95mg: 0.55ml: 550mg: 0.55ml;

[0059] The ratio of paeonol to the water-based solution is that 2g of paeonol is added to every 98g of the water-based solution, that is, the mass percentage of paeonol in the cured composite hydrogel is 2%.

[0060] The preparation method of the above-mentioned injection-type directional slow-release paeonol thermosensitive gel comprises the following steps:

[0061] 1) Weigh chitosan, sodium β-glycerophosphate, hydrochloric acid solution, sodium hydroxide solution and deionized water according to the above rati...

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Abstract

The invention relates to an injection type directional sustained-release paeonol thermosensitive gel and its preparation method. The gel is obtained by dissolving paeonol in a water based solution, and solidifying, and the water based solution is prepared by using chitosan, sodium beta-glycerophosphate, a hydrochloric acid solution, a sodium hydroxide solution and deionized water through certain steps according to a certain ratio. The method concretely comprising the following steps: rapidly dissolving paeonol in the water based solution at 40DEG C to form an injection mixed solution, and injecting the mixed solution into 37DEG C environment to solidify in order to obtain the gel, and the above drug is uniformly dispersed in a gel matrix in a dissolving state in order to realize the slow drug release, so it is beneficial for realizing the minimally invasive filling of defect tissues, and directionally slowly release the paeonol drug to realize antibiosis, antiphlogosis and pain easing in order to make the drug effect more lasting.

Description

technical field [0001] The invention relates to a paeonol drug and a preparation method thereof, in particular to an injection-type directional slow-release paeonol temperature-sensitive gel and a preparation method thereof. Background technique [0002] Paeonol is white or yellowish lustrous crystal, melting point 49°C-51°C, easily soluble in ethanol and methanol, slightly soluble in water, soluble in hot water, insoluble in cold water. It is mainly extracted from the dry root or whole plant of Xu Changqing of Asclepiaceae or the root bark or stem bark of Paeoniaceae plant peony. [0003] Paeonol has the functions of expelling wind and analgesia, detoxifying and reducing swelling, calming the central nervous system, anti-inflammatory, anti-allergy and regulating immunity, etc. It can be used for various pains, and can also be used for pruritus. The dosage forms of paeonol include oral paeonol tablets, soft capsules, and dripping pills, paeonol ointment, plaster, and patch ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/12A61K47/36A61K47/24
Inventor 李光大张建丽杜浩赵三团宋卫东安君岭宋宵薇张玲郭静玉何华伟刘信平
Owner HENAN UNIV OF SCI & TECH
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