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Isoxazole derivative, preparation method and insecticidal composition

A derivative and isoxazole technology, applied in the field of isoxazole derivatives, preparation methods and insecticidal compositions, can solve the problems of increased cost of agricultural products, reduced crop productivity, destruction of agricultural products, etc., and achieve high prevention and control of invertebrate pests, The effect of reducing production cost and environmental load

Inactive Publication Date: 2015-11-18
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Invertebrate pests harm the growth of crops, cause a decrease in crop productivity, damage stored agricultural products, and increase the cost of agricultural products

Method used

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  • Isoxazole derivative, preparation method and insecticidal composition
  • Isoxazole derivative, preparation method and insecticidal composition
  • Isoxazole derivative, preparation method and insecticidal composition

Examples

Experimental program
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preparation example Construction

[0073] The present invention also provides a preparation method of the isoxazole derivative, and its synthetic route is as follows:

[0074]

[0075] Wherein, the position substituted by R is one of ortho, meta and para, and R is selected from Cl, CF 3 , F, Br, OCH 3 、OCF 3 and CH 3 One of them, n=1 or 2 or 3.

[0076] The preparation method of compound 1

[0077] Dissolve 12.2mmol of sodium acetate in 24ml of 50% aqueous hydroxylamine solution, 10mmol of p-chlorobenzaldehyde in 10ml of ethanol, mix the two solutions, and react at 25°C for 40 minutes; use 15ml of the reaction solution After dilution with dichloromethane, extract with water three times (15 ml each time), remove the lower organic phase, combine the lower organic phase, and then distill the organic phase under reduced pressure to obtain the first intermediate.

[0078] NMR data of the first intermediate: 1 HNMR, 300MHz, internal standard TMS, solvent CDCl 3 , δ (mixture of diastereomers) 8.1 (s, 1H), 7....

Embodiment 1

[0146]A pesticidal mixture comprising component (a) and component (b), wherein said component (a) is a compound of formula I, and component (b) is a compound selected from (b1) neonicotinoids pest control agent, and the mass ratio of the component (a) to the component (b) is 25:1-1:20.

Embodiment 2

[0148] A pesticidal mixture comprising component (a) and component (b), wherein said component (a) is a compound of formula I, and component (b) is a choline ester selected from (b2) An enzyme inhibitor, and the mass ratio of the component (a) to the component (b) is 30:1-1:15.

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PUM

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Abstract

The invention discloses an isoxazole derivative, a preparation method thereof and a pesticidal composition. The pesticidal composition comprises a component (a) and a component (b), wherein the component (a) is selected from the isoxazole derivative of a formula I; the component (b) is selected from one of the following invertebrate pest prevention and control agents: (b1) neonicotinoids, (b2) a cholinesterase inhibitor, (b3) a GABA-adjusted chloride ion channel blocker, (b4) a sodium channel adjustor, (b5) a ryanicide acceptor ligand, (b6) an octopamine acceptor ligand, (b7) a nereistoxin analog, and (b8) a biological agent. The pesticidal composition disclosed by the invention shows a high effect of preventing and controlling invertebrate pests, and can be used for lowering the production cost of crops and the environmental load as an arthropod killing agent.

Description

technical field [0001] The invention relates to the field of pest control, in particular to an isoxazole derivative, a preparation method and a pesticidal composition. Background technique [0002] Invertebrate pests harm the growth of crops, reduce crop productivity, destroy agricultural products in storage, and increase the cost of agricultural products. Therefore, controlling invertebrate pests is extremely important to improve crop yield and quality. Invertebrate pests also affect forestry production, greenhouse crops, ornamental plants, livestock, household products, public health and animal hygiene, therefore, the control of invertebrate pests in non-agronomic environments is also very important. [0003] Many products for controlling invertebrate pests are commercially available and can be used alone or as a mixture in production. However, as people pay more and more attention to the environment, it is more and more urgent to seek more economical and safer pest cont...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/653A01N57/16A01N63/00A01P7/04A01P7/02A01P5/00A01N47/40A01N47/24A01N47/22A01N43/24A01N51/00A01N47/02A01N53/08A01N47/38A01N37/44A01N35/10A01N47/12A01N43/36
Inventor 梅向东董梦雅宁君张涛张兰祥司伟杰
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI