Chitosan double-network quick response-type injectable hydrogel and preparation method thereof

A technology of chitosan and water injection, applied in the direction of instruments, analytical materials, measuring devices, etc., can solve the problems of poor mechanical properties of temperature-sensitive gels, unfavorable rapid prototyping, and long response time, and achieve good thermal stability and short transition time control, short response time

Active Publication Date: 2014-07-23
IMEIK TECH DEV CO LTD
View PDF3 Cites 39 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the shortcoming of chitosan thermosensitive gel is that response time is longer, and its solidification time under 37 ℃ physiological environment is not less than 8 minutes (Wu Guangsheng et al., Journal of Dental Endodontics and Periodontology, 2010, 20 (11) , 614); and the mechanical properties of thermosensitive gels are poor, because the formation of the gel network relies on physical interactions such as hydrogen bonds and electrostatic attr...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chitosan double-network quick response-type injectable hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: gel forming method of gel and detection of gel forming time by inversion method

[0027]Weigh 3.0 g of chitosan powder (deacetylation degree 96%, molecular weight 100 kDa), dissolve it in 50 mL of 0.1 mol / L hydrochloric acid solution, and obtain a chitosan solution with a mass fraction of 6%. Take out 9mL of this solution, and add 1mL of sodium glycerophosphate solution with a mass fraction of 50% (in which β-sodium glycerophosphate accounts for 90% of the solid powder of sodium glycerophosphate) dropwise in an ice-water bath at 0°C. After the addition is complete, at this time The pH value of the solution is about 7.2, and the solution is stored at 4°C, and this solution is used as solution A. Weigh 0.11 g of glutaraldehyde (mass ratio to chitosan in liquid A is 0.02:1) and dissolve it in 1 mL of water, and this solution is used as liquid B.

[0028] Put liquid A and liquid B into tube A and tube B respectively, where the maximum volume of tube A is 10 m...

Embodiment 2

[0029] Example 2: Detection of gelation time by cone-plate rotational rheometer

[0030] Weigh 3.0 g of chitosan powder (deacetylation degree 96%, molecular weight 100 kDa), dissolve it in 50 mL of 0.1 mol / L hydrochloric acid solution, and obtain a chitosan solution with a mass fraction of 6%. Take out 9mL of this solution, and add 1mL of sodium glycerophosphate solution with a mass fraction of 50% (in which β-sodium glycerophosphate accounts for 90% of the solid powder of sodium glycerophosphate) dropwise in an ice-water bath at 0°C. After the addition is complete, at this time The pH value of the solution is about 7.2, and the solution is stored at 4°C, and this solution is used as solution A. Weigh 0.11 g of glutaraldehyde (mass ratio to chitosan in liquid A is 0.02:1) and dissolve it in 1 mL of water, and this solution is used as liquid B.

[0031] Put liquid A and liquid B into tube A and tube B respectively, where the maximum volume of tube A is 10 mL, and the maximum v...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Elastic modulusaaaaaaaaaa
Elastic modulusaaaaaaaaaa
Login to view more

Abstract

The invention relates to chitosan double-network quick response-type injectable hydrogel and a preparation method thereof. The injectable hydrogel is prepared from chitosan or derivatives of the chitosan and sodium glycerophosphate serving as raw materials, and dialdehyde compounds or diepoxy compounds serving as crosslinking agents, wherein the mass ratio of the chitosan to the sodium glycerophosphate is 1:(0.5-10); the mass ratio of the crosslinking agents to the chitosan is (0.01-1):1. The method comprises the following steps: evenly mixing a hydrochloric acid aqueous solution of the chitosan with a sodium glycerophosphate solution in the environment at -1 to 5 DEG C, so as to obtain a solution of which the pH is 7-7.2, and evenly mixing the solution with a crosslinking solution at 35-37 DEG C. Transformation from a sol state to a gel state can be quickly finished under a specific condition, the process is irreversible, and the transition time is controllable. The chitosan double-network quick response-type injectable hydrogel has the advantages of simple reaction condition, short response time, good thermal stability of gel, high mechanical strength, good biocompatibility and the like. The chitosan double-network quick response-type injectable hydrogel is applied to the fields such as tissue filling and repairing, biological scaffolds, scar resistance and anti-adhesion, biogel, and quickly molding or three-dimensional printing materials and the like.

Description

technical field [0001] The invention relates to a chitosan double-network fast-response injectable hydrogel and a preparation method thereof. Combining temperature-sensitive gels with chemical cross-linking methods to prepare chitosan double-network fast-response injectable hydrogels. By this method, the obtained chitosan double-network rapid-response gel can quickly complete the transition from the sol state to the gel state under specific conditions, the process is irreversible, and the transition time is controllable. The invention has the advantages of simple reaction conditions, short response time, good thermal stability of the gel, high mechanical strength, good biocompatibility and the like. The invention relates to the fields of tissue filling and repair, biological scaffolds, anti-scar and anti-adhesion, biological glue, rapid prototyping or three-dimensional printing materials and the like. Background technique [0002] Chitosan (chitosan, CS) is the product of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08J3/24C08L5/08C08K5/053G01N11/00
Inventor 简军李睿智
Owner IMEIK TECH DEV CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap