Heparin sodium injection and preparation method thereof

A technology of heparin sodium and injection, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of enhanced toxic and side effects, affecting stability, and reducing drug efficacy, so as to improve stability, The effect of maintaining stability and simple formula

Inactive Publication Date: 2014-08-06
CHENGDU HAITONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Heparin sodium is easily hydrolyzed under acidic conditions, and it is easy to oxidize with oxidants in the production process to inactivate and affect stability (see: Zuo Yong, Pan Xunhai. Research on factors affecting the stability of heparin sodium[J]. Journal of Sichuan Institute of Technology , 2009, 22 (

Method used

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  • Heparin sodium injection and preparation method thereof
  • Heparin sodium injection and preparation method thereof
  • Heparin sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A heparin sodium injection, the injection consists of the following components:

[0023] Heparin sodium 25g, sodium chloride 80g, add water for injection to 10000ml, adjust pH to 5.8-6.8 with sodium hydroxide or hydrochloric acid.

Embodiment 2

[0025] A heparin sodium injection, the injection consists of the following components:

[0026] Heparin sodium 350g, sodium chloride 100g, add water for injection to 10000ml, adjust pH to 5.8-6.8 with sodium hydroxide or hydrochloric acid.

Embodiment 3

[0028] A heparin sodium injection, the injection consists of the following components:

[0029] Heparin sodium 50g, sodium chloride 85g, add water for injection to 10000ml, adjust pH to 5.8-6.8 with sodium hydroxide or hydrochloric acid.

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PUM

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Abstract

The invention discloses a heparin sodium injection. The injection is prepared from the following components in parts by weight: 25-300 parts of heparin sodium, 80-100 parts of sodium chloride and the balance of injection water, wherein the pH of the injection is regulated to 5.8-6.8 with sodium hydroxide or hydrochloric acid. The invention further discloses a preparation method of the injection. The injection is formed by combining heparin sodium, sodium chloride, injection water, nitrogen and a packaging bottle, wherein the nitrogen is saturated, and the injection is packaged by an ampoule bottle or a tube-type bottle. The heparin sodium injection is simple in formula; compared with the prior art, the heparin sodium injection, in the range of dosage portion and pH value, has the advantages of impurity amount reduction and high product quality, is simple in preparation process and stable in quality, and is suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and relates to an injection, in particular to a preparation method capable of increasing the stability of heparin sodium injection. Background technique [0002] Heparin sodium is the sodium salt of aminodextran sulfate extracted from the intestinal mucosa of pigs or cattle. It is a mucopolysaccharide substance and belongs to an anticoagulant drug. It can be taken up by vascular endothelial cells after entering the human body. It is commonly used clinically Prevention and treatment of thrombosis or embolism diseases (such as myocardial infarction, thrombophlebitis, pulmonary embolism, etc.); disseminated intravascular coagulation (DIC) caused by various reasons; also used in hemodialysis, extracorporeal circulation, catheterization, microvascular surgery Anticoagulant treatment of certain blood specimens or instruments during operations such as Heparin sodium is easily hydroly...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/727
Inventor 李晓琳刘冬丹张安玲
Owner CHENGDU HAITONG PHARMA
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