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Compound medicine composition containing bilastine and dimemorfan phosphate

A technology of dimethylphene phosphate and a composition, which is applied in the field of medicine and achieves the effects of fast onset, high safety and high bioavailability

Inactive Publication Date: 2014-08-27
HEFEI IND PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More preferably 20:10:200

Method used

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  • Compound medicine composition containing bilastine and dimemorfan phosphate
  • Compound medicine composition containing bilastine and dimemorfan phosphate
  • Compound medicine composition containing bilastine and dimemorfan phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Bilastine + Dimethyrphane Phosphate + Acetaminophen Granules (according to 1000 bags)

[0044] components

Dosage

Bilastine

5.0g

Dimethylorphinyl Phosphate

10.0g

Acetaminophen

200.0g

lactose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1.0g

fragrance

4.0g

[0045] Preparation:

[0046] Pass Bilastine, Dimethyrphan Phosphate, Acetaminophen, Lactose, and Aspartame through 80 mesh sieve respectively, mix well, dissolve carmine in water, make soft material, granulate with 20 mesh sieve, and dry , 18-mesh sieve, add essence and magnesium stearate, mix well, and divide into bags.

Embodiment 2

[0048] Bilastine + Dimethyrphan Phosphate + Paracetamol Tablets (Based on 1000 Tablets)

[0049] components

Dosage

[0050] Bilastine

10.0g

Dimethylorphinyl Phosphate

10.0g

Acetaminophen

200.0g

microcrystalline cellulose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1.0g

fragrance

4.0g

[0051] Preparation:

[0052] Pass Bilastine, Dimethyrphane Phosphate, Acetaminophen, Microcrystalline Cellulose, and Aspartame through 80-mesh sieve respectively, mix well, dissolve carmine in water, make soft material, and make soft material through 20-mesh sieve granules, dried, sieved with 18 mesh, added essence and magnesium stearate, mixed evenly, and then pressed into tablets.

Embodiment 3

[0054] Bilastine + Dimethyrphane Phosphate + Acetaminophen Solution (according to 1000 bottles)

[0055] components

Dosage

Bilastine

20.0g

Dimethylorphinyl Phosphate

30.0g

Acetaminophen

200.0g

sodium benzoate

3.0g

aspartame

20.0g

sodium bisulfite

2.0g

fragrance

4.0g

water

10000ml

[0056] Preparation:

[0057] Dissolve bilastine, dimethylorphane phosphate, and acetaminophen in an appropriate amount of water, heat and stir to dissolve them, then add sodium benzoate, aspartame, sodium bisulfite and essence, filter and add water to the prescribed amount, stir Divide evenly.

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PUM

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Abstract

The invention relates to the field of medicines, and in particular relates to a compound medicine composition containing bilastine, dimemorfan phosphate and paracetamol, and a preparation method of the medicine composition. The pharmacodynamic tests show that the three components take a synergistic effect into play for preventing cold, and thus the medicine composition can be applied to clinical treatment of cold.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound pharmaceutical composition containing bilastine, dimethylorphin phosphate and acetaminophen and a preparation method thereof. Background technique [0002] Flu is a common frequently-occurring disease, mostly caused by respiratory tract infection. Dry throat, itchy throat or burning sensation, followed by sneezing, nasal congestion, nasal discharge, sore throat, dull taste, poor breathing, hoarseness, coughing, etc. Clinically, due to the complexity of the pathogenesis of colds, symptomatic treatment is mainly used at present to relieve various discomfort symptoms brought by colds to patients. [0003] The mechanism of action of non-steroidal anti-inflammatory drugs is mainly to inhibit cyclooxygenase, reduce the synthesis of prostaglandins, and have antipyretic, analgesic, and anti-inflammatory effects. These drugs mainly include acetaminophen, ibuprofen, and indole Mexicin,...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61P11/14A61P29/00A61P31/16A61K31/454A61K31/167
Inventor 刘为中何广卫陈娟
Owner HEFEI IND PHARMA INST
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