Unlock instant, AI-driven research and patent intelligence for your innovation.

Water-soluble multifunctional CoFe2O4@MnFe2O4@polypyrrole satellite structure nanomaterial and preparation method and application thereof

A cofe2o4mnfe2o4, pyrrole satellite technology, applied in the field of nanomaterials, to achieve the effect of uniform shape, good biocompatibility, and less toxic and side effects

Inactive Publication Date: 2014-08-27
SHANGHAI NORMAL UNIVERSITY
View PDF1 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the etiology and pathogenesis of malignant tumors are still unknown, there is no simple treatment or drug that can cure all tumors, and most tumors require comprehensive treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-soluble multifunctional CoFe2O4@MnFe2O4@polypyrrole satellite structure nanomaterial and preparation method and application thereof
  • Water-soluble multifunctional CoFe2O4@MnFe2O4@polypyrrole satellite structure nanomaterial and preparation method and application thereof
  • Water-soluble multifunctional CoFe2O4@MnFe2O4@polypyrrole satellite structure nanomaterial and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of CoFe 2 o 4 MnFe 2 o 4 For magnetic composite nanomaterials, refer to the literature Journal of the American Chemical Society2004126(1), 273-279.

Embodiment 2

[0028] CoFe prepared in Example 1 2 o 4 MnFe 2 o 4 200 mg of nanomaterials were dispersed in 20 mL of n-hexane. Weigh 0.14gNOBF 4 , dissolved in 20 mL of chloroform. The above two solutions were mixed and reacted for 5 minutes, then centrifuged, washed once with ethanol and water, and dispersed in 8 mL of secondary water to obtain water-soluble CoFe 2 o 4 MnFe 2 o 4 nanomaterials.

Embodiment 3

[0030] Weigh 0.8g polyvinyl alcohol (PVA) and dissolve it in 10mL of secondary water to make a solution, then weigh 0.8g FeCl 3 ·6H 2 O solution in it, forming PVA and FeCl 3 mixed solution. The above mixed solution was mixed with the solution obtained in Example 2 and mechanically stirred for 12 h. Subsequently, 0.2 mL of pyrrole monomer was slowly added to the above solution under stirring, and reacted for 24 hours. After the reaction was completed, 40 mL of absolute ethanol was added to the reaction system, and the product was centrifuged, washed three times with absolute ethanol, and finally dispersed in secondary water.

[0031] figure 1 This is the TEM image of the material prepared in this example. It can be seen from the figure that the synthesized material has a spherical structure, uniform shape, and an average particle size of 70 nm.

[0032] figure 2Be the infrared spectrogram of making material in the present embodiment, wherein 1554 and 1450cm -1 The char...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a water-soluble multifunctional CoFe2O4@MnFe2O4@polypyrrole satellite structure nanomaterial and a preparation method and application thereof. The specific preparation method comprises the following steps: exchanging oil-soluble CoFe2O4@MnFe2O4@ nanoparticles serving as a raw material with a NOBF4 ligand to turn the oil-soluble CoFe2O4@MnFe2O4 into water-soluble nanoparticles; and finally wrapping the water-soluble CoFe2O4@MnFe2O4 nanoparticles with polypyrrole in a satellite form through a surface polymerization method. The obtained product has very high stability and biocompatibility, can be applied to magnetic imaging, photo-thermal and magnetic-thermal treatment, can be used for killing cancer cells, and is a multifunctional magnetic nanomaterial.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to a water-soluble multifunctional CoFe 2 o 4 MnFe 2 o 4 Polypyrrole satellite structure nanomaterials and their application in combined photothermal and magnetic thermal therapy for cancer cells. Background technique [0002] Cancer is the largest public health problem in the world. The treatment methods for malignant tumors mainly include shell therapy, radiation therapy, and chemical drug therapy. Adjuvant therapy methods include tumor biotherapy, heating therapy, cryotherapy, interventional therapy, photodynamic therapy, electrochemical treatment etc. Since the etiology and pathogenesis of malignant tumors are still unknown, there is no simple treatment or drug that can cure all tumors, and most tumors require comprehensive treatment. Tumor thermotherapy, as a therapeutic method with clear curative effect, is gaining widespread attention and recognition in the academic circles....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/12A61P35/00
Inventor 周治国王俊李向远王力张浩朱永吉杨仕平
Owner SHANGHAI NORMAL UNIVERSITY