Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oil-in-water compound apramycin nanoemulsion

A technology of apramycin and oil-in-water type, which is applied in the field of medicine, can solve the problems of inability to obtain curative effect, single effect of apramycin, and unsatisfactory preparation type, so as to achieve better antibacterial effect and maintain blood medicine Concentration and pharmacological effects, and the effect of improving bioavailability

Active Publication Date: 2016-08-24
HENAN SOAR VETERINARY PHARMA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition to the unsatisfactory types of existing preparations, apramycin alone has a single effect and cannot obtain a more ideal curative effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oil-in-water compound apramycin nanoemulsion
  • Oil-in-water compound apramycin nanoemulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of oil-in-water type compound apramycin nanoemulsion, its percentage by weight is composed of: apramycin 7.6%, rhubarb extract 6.3%, EL-40 (surfactant) 24%, ethanol (cosurfactant ) 4%, ethyl acetate (oil) 13%, distilled water 45.1%.

[0025] Weigh 6.3g of rhubarb extract and dissolve in 45.1g of distilled water; weigh 7.6g of apramycin, 24g of EL-40, and 4g of ethanol and stir evenly at room temperature (25°C), then slowly drop in the dissolved rhubarb extract of distilled water. As the amount of distilled water increases, the viscosity of the system increases; when the amount of distilled water added makes the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state, and at this time It is colorless and transparent compound apramycin nanoemulsion.

Embodiment 2

[0027] An oil-in-water type compound apramycin nanoemulsion, which is composed of: 5.3% apramycin, 9.5% rhubarb extract, 25% EL-40 (surfactant), 1,2-propanediol ( co-surfactant) 15%, ethyl oleate (oil) 14%, distilled water 31.2%.

[0028] Its preparation method refers to embodiment 1.

Embodiment 3

[0030] An oil-in-water type compound apramycin nanoemulsion, which is composed of: 1.2% apramycin, 4.3% rhubarb extract, 30% RH-40 (surfactant), glycerol (surface aid) active agent) 15%, isopropyl myristate (oil) 19%, distilled water 30.5%.

[0031] Its preparation method refers to embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Oil-in-water compound apramycin nanoemulsion belongs to the field of medical technology, and its weight percentage is composed of: apramycin 1%-18%, rhubarb extract 1%-20%, and surfactant 15%-40% , Co-surfactant 1% to 25%, oil 1% to 20%, distilled water 20% to 80%. The compound apramycin bacteriostatic nanoemulsion of the present invention has a narrow emulsion particle size distribution, a transparent system, good stability, low surface tension, good fluidity and convenient administration. The combination of rhubarb extract and apramycin has a better antibacterial effect, and it is made into a nanoemulsion, which is easier to be absorbed by the body and can reduce the amount and frequency of use of drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel antibacterial drug—oil-in-water compound apramycin nanoemulsion. Background technique [0002] Apramycin, also known as apramycin, is a new aminoglycoside veterinary antibiotic produced by Streptomyces obscurus. Apramycin was successfully developed by the United States in the 1980s. It has a strong antibacterial effect on Gram-negative bacteria, especially Escherichia coli and Salmonella, which are resistant to other antibiotics. Bacteria (some Streptococcus), Treponema and some Mycoplasma also have good antibacterial effect. Apramycin is characterized by a wide antibacterial spectrum and is not easy to produce drug resistance. It can be used for infections caused by chicken Escherichia coli, Salmonella and mycoplasma. As a drug-type feed additive, apramycin can significantly promote weight gain and improve feed conversion rate, and is widely used in the fi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/708A61P31/04A61K31/7036
Inventor 孙江宏王胜乐管倩
Owner HENAN SOAR VETERINARY PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com