Long-circulating and targeting synergistic multifunctional anti-tumor targeting nano-drug carrier

Abstract

The invention provides a long-circulating and targeting synergistic multifunctional anti-tumor targeting nano-drug carrier. The carrier is composed of a composite micelle which has a grain size of 30-200nm and is even in distribution, wherein the composite micelle is composed of two amphiphilic block copolymers, including a pH-responsive amphiphilic block copolymer of which the hydrophyllic terminal is modified by a targeting group and an amphiphilic block copolymer of which the hydrophyllic terminal is PEG; the composite micelle is of a core-shell structure at pH 7.4, the core layer is composed of the hydrophobic terminals of the amphiphilic block copolymers, while the shell layer is composed of PEG and the targeting group-modified pH-responsive hydrophobic terminal. The long-circulating and targeting synergistic multifunctional anti-tumor targeting nano-drug carrier has the advantages that the surface structure of the drug carrier can be flexibly controlled by changing the proportions of the different block copolymers, the targeting group has specific targeting effect on tumor cells, and the drug carrier has responsible release capacity, excellent biocompatibility and biodegradability; the preparation process of the drug carrier is simple and easy to operate.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and nanomedicine, in particular to a multifunctional anti-tumor targeting nano drug carrier with long circulation and targeting synergy. Background technique [0002] Cancer is a malignant disease that affects human health. In the past three decades, the incidence of cancer in the world has increased at a rate of 3-5% per year, seriously endangering people's physical and mental health. The current treatment strategy for tumors is a combination of chemotherapy, surgical resection, radiotherapy and biological therapy. Among them, drug chemotherapy is one of the main means of treating tumors. The anti-tumor chemotherapy drugs used are still mainly small molecule cytotoxic drugs, and these drugs are widely distributed in the body after administration. At the same time, the vast majority of anti-tumor drugs are hydrophobic, and few of them can reach tumor tissues after intravenous administration, ...

AI Technical Summary

Problems solved by technology

Nevertheless, most of the current PEG decapping studies are still at the cellular level, and in vivo validation has not yet been achieved.

At the same time, the shelling process and mechanism of shelling are relatively complicated, and the scope of application is narrow

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