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Application of castanapetmine in preparation of anti-AIDS drugs

A technology of anti-AIDS and drugs, applied in the field of medicine

Inactive Publication Date: 2014-10-01
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through literature search, it has not been seen that sorghine has been used in the preparation of anti-AIDS drugs in China

Method used

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  • Application of castanapetmine in preparation of anti-AIDS drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of chestnut sourine

[0025] Take 500g of dried leaf powder of Dahuabudou, put it in an extraction kettle, add methanol as an entrainer at a solid-to-liquid volume ratio of 5:2, and feed in liquid CO at a pressure of 22MPa and a temperature of 38°C 2 , CO 2 The flow rate is 4.5ml / g crude drug / min, extract for 120min, analyze at a pressure of 7MPa and a temperature of 32°C, collect the extract, add 15g of diatomaceous earth to stir for decolorization, filter to obtain a decolorization solution, and concentrate to a relative density of 1.12, above eluted with petroleum ether-ethyl acetate 3:14 to obtain the crude sourine of chestnut seed; with methanol at a volume ratio of 19:38:45 -Acetonitrile-water is the mobile phase, the crude product is dissolved in the mobile phase, injected into the preparative high-performance liquid chromatograph, the flow rate is controlled to be 20ml / min, the target fraction is collected, prepared continuously, and freeze-drie...

Embodiment 2

[0045] Tablet: 40g of chestnut soycine, 135g of starch, 25g of chenodeoxycholate, granulated and compressed into 1000 tablets. Dosage: Adults take 1 tablet at a time, 2 times a day.

Embodiment 3

[0047] Capsules: 40g of chestnut sourine, 135g of starch, 25g of chitosan, mixed well, made into 1000 capsules. Dosage: Adults take 1 capsule at a time, 2 times a day.

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Abstract

The invention discloses application of castanapetmine in preparation of anti-AIDS drugs. By virtue of an in vitro cytotoxicity test and an HIV in vitro inhibit assay, anti-HIV effects of the chestnut seed spectabiline are observed, and the results indicate that the c castanapetmine has a certain inhibiting effect for HIV-1 standard strain, clinical strain and pseudovirus, has activity for inhibiting HIV-1 virus replication. The castanapetmine and the medically acceptable auxiliaries are prepared into an anti-HIV drug, wherein a dosage form of the drug is one of injection, capsule, tablet, granule, pill, mixture and oral liquid.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of sowine in the preparation of anti-AIDS drugs. Background technique [0002] Chestnut sourine (Castanospermine) is from the leguminous plant Alexa grandiflora An indole alkaloid active ingredient isolated from the leaves of Ducke. Modern pharmacological studies have shown that sowine can inhibit α-glucoside Ⅰ, Ⅱ and change glycogen metabolism in rats; inhibit the growth of HIV-1 and HIV-2, and inhibit the reproduction of HIV in human cells. AZT combined treatment of AIDS; antiviral effect, the IC50 of murine leukemia virus is 1.0μg / mL; inhibition of tumor metastasis, intraperitoneal injection of 500mg / kg once a day to Lewis lung cancer mice, on the 18th day, the average tumor weight was inhibited by 25% and 40%, the average inhibition of metastatic lesions is 49% and 50%; anti-inflammatory effect, oral administration of 60-65mg / (kg·d) in rats has anti-arthritis effect; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P31/18
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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