Sodium alginate microcapsule for tumor microwave hyperthermia technology, and preparation method and application thereof
A technology of sodium alginate and microwave hyperthermia, which is applied in the direction of microcapsules, capsule delivery, antineoplastic drugs, etc., can solve the problems of insufficient development and application, in-depth research of microwave hyperthermia, and difficult choice of materials, etc., to achieve Good clinical application value, improving the efficiency of diagnosis and treatment, and the effect of good treatment effect
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Embodiment 1
[0046] (1) Preparation of core material solution:
[0047] Stir and dissolve sodium alginate in deionized water to obtain a 1wt% sodium alginate solution, add sodium chloride to the sodium alginate solution as the core material, the mass ratio of sodium chloride to sodium alginate is 1:10, stir and disperse evenly ;
[0048] (2) Emulsification step to form a W / O emulsion:
[0049] Take the mixed solution of sodium alginate and sodium chloride obtained in step (1) into an Erlenmeyer flask, add liquid paraffin and emulsifier in turn, the volume ratio of the water phase to the oil phase is 1:10, the emulsifier used is Span80, and the emulsifier The volume fraction is 0.05%, and magnetically stirred for 30 minutes to obtain a homogeneous milky white W / O emulsion;
[0050] (3) microcapsule wall curing step:
[0051] In the W / O emulsion that step (2) obtains, add calcium chloride as solidifying agent, stir magnetically for 30 minutes, form stable microcapsule wall;
[0052] (4) ...
Embodiment 2
[0057] (1) Preparation of core material solution:
[0058] Stir and dissolve sodium alginate in deionized water to obtain a 10wt% sodium alginate solution, add potassium chloride to the sodium alginate solution as the core material, the mass ratio of potassium chloride to sodium alginate is 1:5, stir and disperse evenly ;
[0059] (2) Emulsification step to form a W / O emulsion:
[0060] Take the mixed solution of sodium alginate and potassium chloride obtained in step (1) into the Erlenmeyer flask, add liquid paraffin and emulsifier in turn, the volume ratio of the water phase and the oil phase is 1:5, the emulsifier used is Span80, emulsifying The volume fraction of the agent is 0.5%, and magnetic stirring is carried out for 30 minutes to obtain a homogeneous milky white W / O emulsion;
[0061] (3) microcapsule wall curing step:
[0062] In the W / O emulsion that step (2) obtains, add calcium chloride as solidifying agent, stir magnetically for 30 minutes, form stable microc...
Embodiment 3
[0068] (1) Preparation of core material solution:
[0069] Stir and dissolve sodium alginate in deionized water to obtain a 5wt% sodium alginate solution, add ammonium chloride to the sodium alginate solution as the core material, the mass ratio of ammonium chloride to sodium alginate is 1:10, stir and disperse evenly ;
[0070] (2) Emulsification step to form a W / O emulsion:
[0071] Take the mixed solution of sodium alginate and ammonium chloride obtained in step (1) into an Erlenmeyer flask, add liquid paraffin and emulsifier in sequence, the volume ratio of the water phase to the oil phase is 1:1, the emulsifier used is Span80, emulsifying The volume fraction of the agent is 0.1%, and magnetic stirring is carried out for 30 minutes to obtain a homogeneous milky white W / O emulsion;
[0072] (3) microcapsule wall curing step:
[0073] In the W / O emulsion that step (2) obtains, add calcium chloride as solidifying agent, stir magnetically for 30 minutes, form stable microca...
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