Sodium alginate microcapsule for tumor microwave hyperthermia technology, and preparation method and application thereof

A technology of sodium alginate and microwave hyperthermia, which is applied in the direction of microcapsules, capsule delivery, antineoplastic drugs, etc., can solve the problems of insufficient development and application, in-depth research of microwave hyperthermia, and difficult choice of materials, etc., to achieve Good clinical application value, improving the efficiency of diagnosis and treatment, and the effect of good treatment effect

Active Publication Date: 2014-10-01
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although microwave hyperthermia technology has the characteristics of non-invasive or minimally invasive and good safety, its huge potential has not been fully developed and applied at present, mainly because the research related to microwave hyperthermia is not in-depth, such as microwave sensitization. Difficult choice of material
In the past, materials such as magnetic nanoparticles used for hyperthermia in vivo have poor biocompatibility and have certain toxicity to organisms.

Method used

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  • Sodium alginate microcapsule for tumor microwave hyperthermia technology, and preparation method and application thereof
  • Sodium alginate microcapsule for tumor microwave hyperthermia technology, and preparation method and application thereof
  • Sodium alginate microcapsule for tumor microwave hyperthermia technology, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Preparation of core material solution:

[0047] Stir and dissolve sodium alginate in deionized water to obtain a 1wt% sodium alginate solution, add sodium chloride to the sodium alginate solution as the core material, the mass ratio of sodium chloride to sodium alginate is 1:10, stir and disperse evenly ;

[0048] (2) Emulsification step to form a W / O emulsion:

[0049] Take the mixed solution of sodium alginate and sodium chloride obtained in step (1) into an Erlenmeyer flask, add liquid paraffin and emulsifier in turn, the volume ratio of the water phase to the oil phase is 1:10, the emulsifier used is Span80, and the emulsifier The volume fraction is 0.05%, and magnetically stirred for 30 minutes to obtain a homogeneous milky white W / O emulsion;

[0050] (3) microcapsule wall curing step:

[0051] In the W / O emulsion that step (2) obtains, add calcium chloride as solidifying agent, stir magnetically for 30 minutes, form stable microcapsule wall;

[0052] (4) ...

Embodiment 2

[0057] (1) Preparation of core material solution:

[0058] Stir and dissolve sodium alginate in deionized water to obtain a 10wt% sodium alginate solution, add potassium chloride to the sodium alginate solution as the core material, the mass ratio of potassium chloride to sodium alginate is 1:5, stir and disperse evenly ;

[0059] (2) Emulsification step to form a W / O emulsion:

[0060] Take the mixed solution of sodium alginate and potassium chloride obtained in step (1) into the Erlenmeyer flask, add liquid paraffin and emulsifier in turn, the volume ratio of the water phase and the oil phase is 1:5, the emulsifier used is Span80, emulsifying The volume fraction of the agent is 0.5%, and magnetic stirring is carried out for 30 minutes to obtain a homogeneous milky white W / O emulsion;

[0061] (3) microcapsule wall curing step:

[0062] In the W / O emulsion that step (2) obtains, add calcium chloride as solidifying agent, stir magnetically for 30 minutes, form stable microc...

Embodiment 3

[0068] (1) Preparation of core material solution:

[0069] Stir and dissolve sodium alginate in deionized water to obtain a 5wt% sodium alginate solution, add ammonium chloride to the sodium alginate solution as the core material, the mass ratio of ammonium chloride to sodium alginate is 1:10, stir and disperse evenly ;

[0070] (2) Emulsification step to form a W / O emulsion:

[0071] Take the mixed solution of sodium alginate and ammonium chloride obtained in step (1) into an Erlenmeyer flask, add liquid paraffin and emulsifier in sequence, the volume ratio of the water phase to the oil phase is 1:1, the emulsifier used is Span80, emulsifying The volume fraction of the agent is 0.1%, and magnetic stirring is carried out for 30 minutes to obtain a homogeneous milky white W / O emulsion;

[0072] (3) microcapsule wall curing step:

[0073] In the W / O emulsion that step (2) obtains, add calcium chloride as solidifying agent, stir magnetically for 30 minutes, form stable microca...

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Abstract

The invention discloses a sodium alginate microcapsule for tumor microwave hyperthermia technology. The diameter of the microcapsule is 1-10 microns, and the shell thickness of the microcapsule is 100-1000 nm. According to the invention, the sodium alginate microcapsule is firstly applied to the technical field of tumor microwave hyperthermia, and an excellent curative effect is obtained, so that the diagnosis and treatment efficiency is greatly improved, and an excellent clinical application value is provided.

Description

technical field [0001] The invention relates to the field of microcapsule technology and its biological application. More specifically, it relates to a sodium alginate microcapsule used in microwave hyperthermia technology for tumors and its preparation and application. Background technique [0002] At present, cancer has become one of the major diseases leading to human death (Nanoscale, 2012, 4, 330-342, Nanoscale, 2013, 5, 12409-12424). According to the World Cancer Report 2014 by the World Health Organization, the number of cancer patients and deaths in the world increased disturbingly in 2012, with more than 14 million new cases of cancer worldwide, increasing year by year to 19 million in 2025. It will reach 24 million people by 2035. The report also shows that developing countries in Africa, Asia, and Central and South America have the most serious cancer incidence. In 2012, there were 14 million new cancer cases and 8.2 million deaths worldwide. Among them, China...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/50A61K47/36A61P35/00
Inventor 孟宪伟史海堂付长慧任湘菱任俊
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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