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Membrane filtration process method of meleumycin

A technology of mebamycin and process method, which is applied in the direction of chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the difficulty of transportation and treatment of fungus residue, affect product quality and yield, and require a lot of manpower and material resources and other issues, to achieve the effect of environmental protection treatment, improvement of labor efficiency, and fast filtration speed

Inactive Publication Date: 2014-10-22
CHONGQING DAXIN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The plate and frame filter press process has several disadvantages: first, the traditional plate and frame filter consumes a lot of manpower and material resources; Elemental zinc, the water content of the bacteria residue after plate and frame pressure filtration is as high as 65-80%. The high water content and heavy metal salts bring great difficulties to the transportation and treatment of the bacteria residue, especially the inclusion of antibiotic residues into hazardous solid waste Management, in the situation of increasing requirements for environmental protection, this solid-liquid separation method is increasingly showing its disadvantages in the production of mebelamycin; third, plate and frame pressure filtration cannot remove macromolecular soluble proteins, sugars, and pigments and other impurities, the quality of the filtrate is poor, and it is prone to emulsification during subsequent extraction, which affects product quality and yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 50 tons of mebamycin fermented liquid is adjusted to pH4.0 with oxalic acid, then filter with a ceramic membrane filter with a molecular weight cut-off of 0.1um of 100,000 to obtain 40 tons of filtrate, and then use 2 times the volume of concentrated bacterial residue Purified water with pH 4.1 was used for top washing, and 60 tons of filtrates were combined. The filtrate was adjusted to pH9.5 with sodium hydroxide solution, and 6.0m 3 The butyl acetate was mixed evenly, and the heavy liquid was separated and removed by a disc centrifuge to obtain a butyl acetate extract. Add a phosphoric acid solution with a pH of 1.8 under stirring, the amount added is 30% of the volume of butyl acetate, and after fully stirring evenly, let it stand for stratification, and the mebelamycin is transferred from the organic phase of butyl acetate to the lower aqueous phase. Separate the lower layer solution. The phase inversion solution was adjusted to pH 8.5 with sodium hydroxide solut...

Embodiment 2

[0040]Adjust 50 tons of mebamycin fermented liquid to pH 3.7 with oxalic acid, then filter with a ceramic membrane filter with a molecular weight cut-off of 0.1um to obtain 40.5 tons of filtrate, and then use 2 times the volume of concentrated bacterial residue Purified water with pH 4.2 was used for top washing, and 61 tons of filtrates were combined. The filtrate was adjusted to pH9.39 with sodium hydroxide solution, and 6.1m 3 The butyl acetate was mixed evenly, and the heavy liquid was separated and removed by a disc centrifuge to obtain a butyl acetate extract. Add the phosphoric acid solution of pH 1.82 under stirring, the addition amount is 34% of the butyl acetate volume, after fully stirring evenly, let it stand for stratification, and the mebelamycin is transferred from the butyl acetate organic phase to the lower aqueous phase, Separate the lower layer solution. The phase inversion solution was adjusted to pH 8.3 with sodium hydroxide solution, and a large number ...

Embodiment 3

[0043] 50 tons of mebamycin fermented liquid is adjusted to pH 4.3 with oxalic acid, and then filter with a ceramic membrane filter with a molecular weight cut-off of 0.1um to obtain 39.8 tons of filtrate, and then use 2 times the volume of concentrated bacterial residue Purified water with pH 3.9 was used for top washing, and 60 tons of filtrates were combined. The filtrate was adjusted to pH9.7 with sodium hydroxide solution, and 6.2m 3 The butyl acetate was mixed evenly, and the heavy liquid was separated and removed by a disc centrifuge to obtain a butyl acetate extract. Add a phosphoric acid solution with a pH of 1.79 under stirring, the amount added is 37% of the volume of butyl acetate, and after fully stirring evenly, let it stand for stratification, and the mebelamycin is transferred from the butyl acetate organic phase to the lower aqueous phase. Separate the lower layer solution. The phase inversion solution was adjusted to pH 8.2 with sodium hydroxide solution, a...

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Abstract

The invention discloses a membrane filtration process method of meleumycin, and belongs to a method for extracting and producing antibiotics by solid-liquid separation of a fermentation broth. A flat ultrafiltration membrane, a roll type ultrafiltration membrane or a tubular ultrafiltration membrane is used to filter the fermentation broth to carry out the solid-liquid separation, to obtain a filter solution with relatively high transmittance; the filter solution is subjected to extraction and phase inversion; finally a phase inversed solution is crystallized and then separated by a centrifugal machine; and a crystal is dried to obtain a meleumycin finished product. By using the membrane filtration to replace a conventional plate-frame pressure filtration process, the process method has the following advantages and positive effects of fast filtration speed, good filtration quality, high transmittance, and significantly increased pressure filtration yield, eradicates extraction and emulsion phenomenon, and has high yield of finished product and good quality finished product. Besides, the membrane filtration technology is not complex in investment and reconstruction, is few in additional devices, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of antibiotics, in particular to a membrane filtration process method of mebelamycin. Background technique [0002] Meleumycin (Meleumycin) is a multicomponent sixteen-membered macrolide antibiotic containing medemycin A 1 , Kitamycin A 6 , Midecamycin A 2 , Kitamycin A 4 、A 8 Equal small components, the molecular formula is C 41 h 67 NO 15 .C 40 h 65 NO 15 , the molecular weight is 1613.92. [0003] Mebamycin is prepared by fermenting and extracting a kind of Streptomyces. The existing technology is to add hydrochloric acid or oxalic acid to the fermented liquid to acidify the fermented liquid, then add zinc sulfate and yellow blood salt to flocculate and pass through plate and frame filter press, and the press filter liquid is extracted and Invert the phase, then heat up and crystallize under alkaline conditions, separate the crystals and dry to obtain the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
Inventor 杨德荣谢云张洪兰唐亚雄张葵雷川洋
Owner CHONGQING DAXIN PHARMA
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