Preparation method of nano-silver composite antibacterial agent

A composite antibacterial agent and nano-silver technology, which is applied in the field of preparation of nano-silver composite antibacterial agent, can solve the problems of insufficient stability of silver ions and unsatisfactory fungal inhibition effect, and achieve the effects of low toxicity, safe use performance, and simple experimental operation

Active Publication Date: 2014-11-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to propose a kind of preparation method of nano-silver composite antibacterial agent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dilute 10 parts to a concentration of 1×10 -4 g / ml of benzalkonium bromide solution was added dropwise to 10 parts with a concentration of 1.5×10 -3 g / ml AgNO 3 solution, stir evenly to obtain mixed system A. Dilute 50 parts to a concentration of 1 x 10 -5 g / ml sodium borohydride and 50 parts at a concentration of 1 x 10 - 4 The benzalkonium bromide solution of g / ml was stirred and mixed to obtain the mixed system B. Add the mixed system B to the mixed system A dropwise, and control the addition within 1.5h, stir evenly to obtain the nano-silver solution. Get 10 parts of nano-silver solution, add 1 part of 1 μg / ml butylparaben, stir at room temperature and use concentration as 0.1mol / L NaOH solution or 0.1mol / L HCl solution to adjust the pH value to 4.5 to obtain Nano silver composite antibacterial agent.

Embodiment 2

[0029] Dilute 50 parts to a concentration of 2 x 10 -4 g / ml of benzalkonium bromide solution was added dropwise to 20 parts with a concentration of 1.5×10 -3 g / ml AgNO 3 solution, stir evenly to obtain mixed system A. Dilute 50 parts to a concentration of 1 x 10 -5 g / ml of hydrazine hydrate and 50 parts at a concentration of 2 x 10 - 4 The benzalkonium bromide solution of g / ml was stirred and mixed to obtain the mixed system B. Add the mixed system B to the mixed system A dropwise, and control the addition within 1.5h, stir evenly to obtain the nano-silver solution. Get 10 parts of nano-silver solution, add 1 part of 1 μg / ml butylparaben, stir at room temperature and use concentration as 0.1mol / L NaOH solution or 0.1mol / L HCl solution to adjust the pH value to 4.5 to obtain Nano silver composite antibacterial agent.

Embodiment 3

[0031] The concentration of 50 parts is 3×10 -4 g / ml of benzalkonium bromide solution was added dropwise to 50 parts with a concentration of 1.5×10 -3 g / ml AgNO 3 solution, stir evenly to obtain mixed system A. Dilute 100 parts to a concentration of 1 x 10 -5 g / ml sodium borohydride and 50 parts at a concentration of 3 x 10 - 4 The benzalkonium bromide solution of g / ml was stirred and mixed to obtain the mixed system B. Add the mixed system B to the mixed system A dropwise, and control the addition within 1.5h, stir evenly to obtain the nano-silver solution. Take 20 parts of nano-silver solution, add 5 parts of 2 μg / ml butylparaben and 2 parts of 2 μg / ml isothiazolinone, stir well at room temperature and use a concentration of 0.1mol / L NaOH solution or a concentration of 0.1mol / L HCl solution to adjust the pH value to 4.5 to obtain a nano-silver composite antibacterial agent.

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Abstract

The invention discloses a preparation method of a nano-silver composite antibacterial agent. The invention is characterized in that the nano-silver composite antibacterial agent is formed by combining a nano-silver solution and an organic antibacterial agent which have synergistic effect and adduction effect according to a certain ratio. The structure and performance of the antibacterial agent after combination are stable, and the antibacterial agent has more rapid, efficient and broad-spectrum antibacterial performance. The minimal inhibitory concentration (MIC) of the antibacterial agent for inhibiting escherichia coli, Enterobacter hormaechei, staphylococcus aureus, bacillus subtilis, Rhodotorula mucilaginosa, penicillium and Aspergillus niger is only 1-10 microgram/ml. The preparation method of the nano-silver composite antibacterial agent is characterized in that the nano-silver in the nano-silver composite antibacterial agent has monodispersity and there is no agglomeration phenomenon. The preparation method has advantages of ingenious conception, simple experimental operation, high operationality and short period, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of nano-antibacterial materials, and in particular relates to a preparation method of a nano-silver composite antibacterial agent with broad-spectrum antibacterial properties, high efficiency and stability. Background technique [0002] Nano antibacterial materials are a new class of materials developed on the basis of inorganic antibacterial materials and nanomaterials. Among them, nano-silver has the advantages of high antibacterial performance, good heat resistance, not easy to produce drug resistance and high safety, and it is a hot spot in the research and application of antibacterial materials. In recent years, a variety of inorganic antibacterial materials containing nano-silver have come out, and some of them have been used commercially. A. S., et al. Ultradilute Ag-aquasols with extraordinary bacterial properties: role of the system Ag-O-H 2 O [J]. Materials research innovations 2007, 11(1): 3-11....

Claims

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Application Information

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IPC IPC(8): A01N59/16A01P3/00A01P1/00A01N37/40A01N31/16A01N43/80
Inventor 陈武勇杨威特唐秋月李慧张金伟
Owner SICHUAN UNIV
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