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Preparation method of belladonna extract

The technology of belladonna extract and belladonna grass is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc. Low effect, less alkaloid loss and simple process

Inactive Publication Date: 2018-09-14
HUNAN UNIV OF SCI & ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Above-mentioned each method, process is complicated, and the alkaloid extraction that belladonna contains is incomplete, takes a long time, and ethanol consumption is big

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Get belladonna coarse powder 100 grams, be that the dilute sulfuric acid solution of mass concentration is 0.5% be solvent extraction three times, add the quality of dilute sulfuric acid solution each time to be 600g, extract 3 hours. Combine the extracts, concentrate to a relative density of about 1.2, dissolve 1.5 grams of sodium hydroxide with 2 milliliters of water, add sodium hydroxide solution and 95% ethanol under stirring, until the ethanol concentration reaches 65%, let stand, take the supernatant, After neutralization with dilute sulfuric acid, it was concentrated under reduced pressure to a thick paste and dried at low temperature to obtain 8.7 g of solid.

[0016] Determination of atropine content reached 2.97% in terms of atropine sulfate.

Embodiment 2

[0018] Get 100 grams of belladonna coarse powder, extract three times with a dilute hydrochloric acid solution with a mass concentration of 0.3%, add 1000 g of a dilute sulfuric acid solution each time, and extract for 3 hours. Combine the extracts, concentrate to a relative density of about 1.3, dissolve 1 gram of sodium hydroxide with 2 milliliters of water, add sodium hydroxide solution and 95% ethanol under stirring, until the ethanol concentration reaches 70%, let it stand, and take the supernatant, After neutralization with dilute sulfuric acid, it was concentrated under reduced pressure to a thick paste and dried at low temperature to obtain 8.3 g of solid.

[0019] Determination of atropine content reached 3.62% in terms of atropine sulfate.

Embodiment 3

[0021] Get 100 grams of belladonna coarse powder, extract three times with a dilute sulfuric acid solution with a mass concentration of 1%, add 800 g of a dilute sulfuric acid solution each time, and extract for 3 hours. Combine the extracts, concentrate to a relative density of about 1.1, stir 3.5 grams of calcium hydroxide and dissolve it with 5 milliliters of water, add calcium hydroxide solution and 95% ethanol under stirring until the ethanol concentration reaches 60%, let it stand, and take the supernatant , after neutralization with dilute sulfuric acid, concentrated under reduced pressure to a thick paste, and dried at low temperature to obtain 10.5 g of solid.

[0022] Determination of atropine content reached 2.66% in terms of atropine sulfate.

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Abstract

The invention relates to a preparation method of a traditional Chinese medicine extract, and in particular relates to a preparation method of a belladonna extract. The method comprises the following steps: carrying out reflux extraction on coarse belladonna powder thrice by taking a sulfuric acid aqueous solution as a solvent, concentrating an extracting solution, adding an inorganic base and 95% ethyl alcohol and standing to obtain a supernatant; neutralizing the supernatant with a dilute acid, carrying out reduced pressure concentration on the supernatant until forming a thick paste, thereby obtaining the belladonna extract. The method is simple in process, less in time consumption and low in cost, and ensures that the extraction ratio of alkaloid in belladonna is high and the loss of the alkaloid in an alcohol precipitation process is less. The content of atropine in the prepared belladonna extract is more than 30% higher than that of the atropine prepared in the prior art.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of belladonna extract. Background technique [0002] The belladonna extract obtained through the processing of belladonna is an anticholinergic drug, which can relieve smooth muscle spasm and inhibit gland secretion, and is widely used in the treatment of gastric and duodenal ulcers and gastrointestinal, renal and biliary colic drugs; The compatibility of eggplant extract with vitamin U and aluminum hydroxide is a medicine with better effects in treating stomach pain, flatulence and gastric acid. [0003] According to "Chinese Pharmacopoeia" (page 397 of the 2010 edition), the preparation method of belladonna extract is: get 1000 grams of belladonna coarse powder, use 85% ethanol as a solvent, and soak it at a rate of 1-3ml per minute after 48 hours of immersion. Slowly percolate, collect about 3000ml of the initial percolatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81
Inventor 姜红宇何福林黄光文湛雪辉
Owner HUNAN UNIV OF SCI & ENG
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