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Grinding method of viscous drug zirconium beads

A grinding method and viscous technology, which is applied in the field of pharmaceutical grinding and dispersion, can solve the problems of affecting the grinding quality and drug stability, accelerating the wear and breaking of beads, and affecting the stability of drugs, etc., so as to be beneficial to human body absorption and low production cost , the effect of ensuring drug safety

Active Publication Date: 2016-06-15
SHANGHAI YANAN PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used drug grinding methods include high-pressure impact, homogeneous cutting, etc.; but when applied to viscous drugs, the grinding fineness is not ideal, and it also affects the stability of the drug.
When grinding with grinding beads, when the drug slurry is too thick, it is easy to cause accumulation of grinding beads and direct contact with the wear parts of the grinding machine to accelerate the wear and breakage of the beads, which in turn affects the grinding quality and the stability of the drug.

Method used

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  • Grinding method of viscous drug zirconium beads
  • Grinding method of viscous drug zirconium beads
  • Grinding method of viscous drug zirconium beads

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0032] This embodiment relates to the preparation of zirconium beads (yttria-stabilized zirconia microspheres with a diameter of 1.0 to 2.0 mm) used in the viscous drug zirconium bead grinding method; the method specifically includes the following steps:

[0033] a. Press Y 2 o 3 Content is the ratio of 3mol%, configuration ZrO(NO 3 ) 2 .2H 2 O and Y (NO 3 ) 3 .6H 2 O mixed solution is the mother liquor; take ZrO(NO 3 ) 2 The concentrations are 0.25mol / L, 0.75mol / L, 1.5mol / L respectively;

[0034] b. At 80°C, add chitosan and pectin, adjust the pH value to 1, age and polymerize to form a gel, and dry to obtain a precursor;

[0035] ZrO(NO 3 ) 2 The infrared spectrum of the corresponding precursor when the concentration is 0.75mol / L is as follows figure 1 As shown, the stretching vibration peak of O-H in the gel is around the wave number 3410 / cm, and the stretching vibration peak of -COOH at 1630 / cm is enhanced compared with chitosan and pectin, and at 1422cm -1 Co...

Embodiment 2

[0049] This embodiment relates to a method for grinding viscous drug zirconium beads, specifically using the yttria-stabilized zirconia microbeads with a diameter of 2mm prepared in Example 1 for grinding, specifically: putting the zirconium beads into a rotating disk In the stainless steel container, after adding the viscous drug, start the rotating disc to drive the zirconium beads to roll up and down for grinding, the grinding speed is 800-2800 rpm; the grinding time is adjusted according to the viscosity of the viscous drug.

[0050] Taking nifedipine as an example, the grinding experiment was carried out. Nifedipine belongs to poorly soluble drugs, limited by its solubility characteristics, it has the problems of low dissolution rate and low bioavailability. In order to improve the bioavailability, the particle size is reduced by grinding, the effective dissolution area of ​​the drug is increased, and the dissolution rate of the drug is increased. Grinding efficiency and...

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Abstract

The invention discloses a method for grinding viscous medicine zirconium beads; the method comprises the following steps: preparing round zirconium beads with a diameter of 1.0-2.0 mm; putting the zirconium beads into a stainless steel container equipped with a rotating disk , After adding the viscous drug, start the rotating disk to drive the zirconium beads to roll up and down for grinding, and the grinding speed is 800-2800 rpm. The zirconium beads are made of Y 2 o 3 -ZrO 2 Yttria-stabilized zirconia microbeads formed by powder rolling and sintering. The invention adopts the corresponding technology of combining high-hardness zirconium beads to solve the problem of grinding and dispersing viscous drugs, so that the drugs can be ultra-fine and stable, and the safety of the drugs can be ensured.

Description

technical field [0001] The invention relates to medicine grinding and dispersing technology, in particular to a viscous medicine zirconium bead grinding method. Background technique [0002] Grinding media can be divided into glass beads, ceramic beads (including zirconia silicate beads, zirconia beads, alumina beads) etc. according to different materials. Due to the difference in chemical composition and manufacturing process, the crystal structure of the grinding beads is determined. The dense crystal structure ensures the high strength, high wear resistance and low oil absorption of the beads. The different percentages of various ingredients determine the specific gravity of the grinding beads. The high specific gravity provides a guarantee for high grinding efficiency; the chemical composition of the grinding beads will have a certain impact on the performance of the slurry during the grinding process. Therefore, in addition to considering In addition to low wear rates,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B02C17/10C04B35/48C04B35/622
Inventor 王学亮
Owner SHANGHAI YANAN PHARM
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