Preparation method of biocompatible silicone rubber

A silicone rubber and affinity technology, which is applied in the field of polymer material surface modification, can solve the problems of poor silicone rubber affinity, reduce bacterial adhesion, etc., achieve short processing time, improve hydrophilicity, and reduce viscosity. Additive effect

Inactive Publication Date: 2014-12-10
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the disadvantages of poor affinity of silicone rubber in the prior art, and provide a method for preparing biocompatible silicone rubber. First, hydroxyl-terminated polydimethylsiloxane is mixed with a crosslinking agent Under the action of further cross-linking, the room temperature vulcanized silicone rubber is obtained; then the silicone rubber is treated with plasma to fix the initiator on the surface of the silicone rubber, and the surface-induced atom transfer radical polymerization is used to initiate on the surface of the silicone rubber with the surface-fixed initiator. Polymerization reaction of polar acrylamide, so as to modify the surface of silicone rubber to achieve the purpose of reducing bacterial adhesion, and prepare biocompatible silicone rubber materials

Method used

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  • Preparation method of biocompatible silicone rubber

Examples

Experimental program
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Embodiment 1

[0027] (1) Preparation of room temperature vulcanized silicone rubber

[0028] A: The hydroxyl-terminated polydimethylsiloxane is completely dissolved in tetrahydrofuran, and precipitated in anhydrous methanol, the upper waste liquid is filtered off, and dried in a vacuum oven to obtain purified polydimethylsiloxane oxane.

[0029] B: Weigh 40.0 g, add the polydimethylsiloxane purified in A into a three-necked flask, and stir well to make it evenly mixed. The oil bath was stirred at 110° C. under vacuum for 2 hours, and 2.8 g of methyl tributylketoxime silane (D-30) and 0.40 g of γ-aminopropyl triethoxysilane (KH570) were added. Continue to vacuumize and stir for 0.5h, add 0.2g of dibutyltin dilaurate (DBTL), and vacuumize and stir for 15min, then pour the silica gel into a 2mm thick mold. Vulcanize 2week at room temperature.

[0030] (2) Initiator immobilized on the surface of silicone rubber

[0031] A: Cut the prepared room temperature vulcanized silicone rubber into 1×...

Embodiment 2

[0041] (1) Preparation of deoxime type room temperature vulcanized silicone rubber

[0042] A: The hydroxyl-terminated polydimethylsiloxane is completely dissolved in tetrahydrofuran, and precipitated in anhydrous methanol, the upper waste liquid is filtered off, and dried in a vacuum oven to obtain purified polydimethylsiloxane oxane.

[0043] B: Weigh 40.0 g, add the polydimethylsiloxane purified in A into a three-necked flask, and stir well to make it evenly mixed. Vacuum and stir in an oil bath at 110°C for 1 hour, then add 2.8 g of methyl tributylketoxime silane (D-30) and 4.00 g of γ-aminopropyl triethoxysilane (KH570). Continue to vacuumize and stir for 1 hour, add 0.4 g of dibutyltin dilaurate (DBTL), and vacuumize and stir for 30 minutes, then pour the silica gel into a mold with a thickness of 2 mm. Vulcanize 7d at room temperature.

[0044] (2) Initiator immobilized on the surface of silicone rubber

[0045] A: Cut the prepared room temperature vulcanized silico...

Embodiment 3

[0050] The preparation method of silicone rubber, immobilization initiator on the surface of silicone rubber and grafting PAAM on the surface of silicone rubber is similar to that of Example 1, except that the plasma treatment time is 7 minutes, and the surface grafting reaction time is 24 hours.

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Abstract

The invention provides a preparation method of biocompatible silicone rubber. The method comprises the following steps: (1) fully stirring polydimethylsiloxane, adding a mixed crosslinking agent of a deoximation type crosslinking agent and a dealcoholization type crosslinking agent, continuously vacuumizing and stirring, adding a catalyst and vulcanizing at room temperature; (2) treating room temperature vulcanized silicone rubber by virtue of plasmas and generating hydroxyl active sites on the surface of the silicone rubber; adding silicone rubber and organic amine treated by plasma into a nonpolar solvent, stirring under an icy salt bath, dropwise adding a mixed liquid containing a brominating agent and a nonpolar solvent, removing the icy salt bath, raising to room temperature, and continuously stirring in a dark place to obtain silicone rubber with a bromine group on the surface; and (3) putting the silicone rubber with the bromine group on the surface, an acrylamide monomer and a CuCl/bpy catalyst in a reaction container, injecting a degassed solvent into the reaction container by virtue of an injector, and putting the reaction container in a constant temperature oil bath to react; and washing and drying to obtain hydrophilic silicone rubber grafted with polyacrylamide on the surface.

Description

technical field [0001] The invention relates to a preparation method of bio-affinity silicone rubber, which belongs to the field of surface modification of polymer materials. technical background [0002] Silicone rubber is the largest and most widely used category of silicone products. Because of its good high and low temperature resistance, weather resistance, physiological inertia and other advantages, it is widely used in national defense, medical and health, industrial and agricultural production and people's daily life, and plays an increasingly important role in modern medicine. effect. [0003] After vulcanization, silicone rubber has good mechanical properties, chemical stability, physiological inertness and other advantages, so it has good application prospects in the field of biomedical materials. At present, silicone rubber is widely used in biomedical fields such as artificial lungs, retinal implants, artificial dura mater, artificial heart valve accessories, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08J7/12C08J3/24C08L83/06
Inventor 姜彦瞿鹏张洪文
Owner CHANGZHOU UNIV
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