A three-dimensional patch used for nerve regeneration and epidural restoration and a preparing method thereof

A technology of nerve regeneration and patch, applied in medical science, prosthesis, etc., can solve problems such as acidosis

Inactive Publication Date: 2014-12-24
冯淑芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation of bacterial cellulose into acidic substances, long-term accumulation will lead to acidosis

Method used

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  • A three-dimensional patch used for nerve regeneration and epidural restoration and a preparing method thereof
  • A three-dimensional patch used for nerve regeneration and epidural restoration and a preparing method thereof
  • A three-dimensional patch used for nerve regeneration and epidural restoration and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 0.1g of bacterial cellulose to 9.9g of N-methylmorpholine-N-oxide (NMMO) aqueous solution, first swell at room temperature for 0.5h, then raise the temperature to 120°C and dissolve for 3h until a uniform translucent brown solution. Finally, put it in a vacuum oven, vacuumize and defoam at 30°C, and wait for spinning.

[0032] The bacterial cellulose solution prepared above is passed through a wet spinning machine and double-diffused in water to spin regenerated bacterial cellulose fibers. Finally, the obtained fibers are washed and dried for use. The prepared regenerated bacterial cellulose fibers were braided to prepare a support layer for three-dimensional nerve regeneration and a dura mater patch with a size of 15 cm×4 cm×0.5 cm.

[0033] Put the bacterial cellulose support layer into an acetic acid solution with a deacylation degree of 95% and a molecular weight of 1.5 million chitosan prepared with 1%, carry out plasma reaction through the air in the plasma ...

Embodiment 2

[0036]Add 0.4g of bacterial cellulose to 9.6g of N-methylmorpholine-N-oxide (NMMO) aqueous solution, first swell at room temperature for 5 hours, then raise the temperature to 80°C and dissolve for 8 hours until a uniform transparent brown color is obtained solution. Finally, put it into a vacuum oven, vacuumize and defoam at 50°C, and wait for spinning.

[0037] The bacterial cellulose solution prepared above is passed through a wet spinning machine and double-diffused in NMMO aqueous solution to spin regenerated bacterial cellulose fibers. Finally, the obtained fibers are washed and dried for use. The prepared regenerated bacterial cellulose fibers were woven to form a support layer of a three-dimensional patch with a size of 8 cm×8 cm×0.1 cm.

[0038] Put the bacterial cellulose support layer into the acetic acid solution prepared with 6% deacylation degree of 75% and chitosan with a molecular weight of 500,000, and carry out plasma reaction through the oxygen flow in the...

Embodiment 3

[0041] like figure 1 Shown is a three-dimensional patch for nerve regeneration and dura mater prepared in Example 1 of the present invention, the support layer is made of regeneration-based bacterial fibers with high Young's modulus, high tensile strength and excellent shape maintenance ability Plain weaving; the breaking strength of the bracket is 500CN, the breaking elongation is 30%, the knotting breaking strength is 400CN, and the knotting breaking elongation is 20%.

[0042] The middle layer is coated with antibacterial enhanced deacetylation degree 75%, chitosan with a molecular weight of 2 million is dissolved in 2% acetic acid solution and coated on the regenerated bacterial cellulose patch.

[0043] The outer layer is composed of cross-linked sodium hyaluronic acid with anti-adhesion, strong water holding capacity and water permeability, dissolved in water, coated on the regenerated bacterial cellulose support patch, and dried in vacuum.

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Abstract

The objective of the invention is to provide a three-dimensional patch used for nerve regeneration and epidural restoration and a preparing method thereof. A supporting layer is formed by weaving regenerated bacterial cellulose with a high Young modulus, high tensile strength and excellent shape maintaining capability. A middle layer is formed by covering with a chitosan membrane with high antibacterial performance. An outer layer comprises crosslinked sodium hyaluronate with antiblocking performance, high water binding capacity and water and air permeability. In addition, the bacterial cellulose has high water binding capacity and water and air permeability. The inside of the bacterial cellulose is free of conventional circular holes and has micro channels with different dimensions and large voids, thus guaranteeing that neutrophils in a human body can pass through the voids of a patching screen to phagocytose bacteria easily causing infection, facilitating healing of a wound part and not causing infection of the wound part. The patch is degradable fiber, so that the patch is not needed to be taken out by another operation and pain of patients is reduced.

Description

technical field [0001] The patent of the present invention relates to a three-dimensional patch for nerve regeneration and dura mater repair and its preparation method, in particular to the application of the nerve and dura mater patch fabric prepared by tissue engineering technology in the treatment of medical non-supporting tissue and dura mater. Background technique [0002] Cellulose is an attractive natural biopolymer material whose fibrous structure is morphologically identical to the collagen fibers that make up the nerve head. Its interconnected microstructure scaffold has high porosity and is ideal for nerve regeneration and dura mater repair. The structural characteristics of nanofibers are similar to those of the extracellular matrix of tissues. They have extremely high specific surface area, are more conducive to cell adhesion and growth, have better cell adhesion ability and cell activity, and can act on tissue engineering nerve materials. Bacterial cellulose h...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54
Inventor 冯淑芹
Owner 冯淑芹
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