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A kind of chitosan/gelatin/nano-silver conductive antibacterial biomaterial and preparation method thereof

A biomaterial, nano-silver technology, applied in the direction of electrolytic coating, nanotechnology, coating, etc., can solve the problems of uneven surface, poor mechanical properties, rough structure, etc., and achieve a simple preparation method, simple steps, and easy control Effect

Inactive Publication Date: 2016-09-14
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the deposition layer obtained by electrodeposition of chitosan is generally thinner and has poor mechanical properties, and because the cathode has H 2 The deposited layer often contains a large number of bubbles, which leads to uneven surface and rough structure of the material, and it is difficult to remove the deposited layer from the electrode completely.

Method used

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  • A kind of chitosan/gelatin/nano-silver conductive antibacterial biomaterial and preparation method thereof
  • A kind of chitosan/gelatin/nano-silver conductive antibacterial biomaterial and preparation method thereof
  • A kind of chitosan/gelatin/nano-silver conductive antibacterial biomaterial and preparation method thereof

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Embodiment 1

[0039] A kind of chitosan / gelatin / nano-silver conductive antibacterial biological material, the preparation method is as follows:

[0040] 1) Preparation of nano-silver dispersion: weigh 0.19g NaBH 4 Add to 25mL deionized water, sonicate at room temperature for 5 minutes to get NaBH 4 Solution (concentration is 0.2mol / L), standby; Weigh 0.14gAgNO 3 Add to 200mL deionized water (concentration is 4mmol / L), stir and dissolve at room temperature, then add to the obtained AgNO 3 Add 0.06g of sodium citrate to the solution, and then add NaBH dropwise to the solution at a rate of 2 drops / second under constant temperature magnetic stirring at 25°C. 4 Solution, stop dripping until the solution turns yellowish brown, continue to stir and react for 8 hours; then centrifuge the reacted solution, wash the precipitate with ethanol and acetone for 3 times, and dry it in vacuum at 40°C for 10h to obtain nano-silver; 2.0 ×10 -2 Add 1 g of nano silver into 10 mL of distilled water, and soni...

Embodiment 2

[0050] A kind of chitosan / gelatin / nano-silver conductive antibacterial biological material, the preparation method is as follows:

[0051] 1) Preparation of nano-silver dispersion: weigh 0.15g NaBH 4 Add to 20mL deionized water, sonicate at room temperature for 3 minutes to get NaBH 4 Solution (concentration is 0.2mol / L), standby; Weigh 0.1gAgNO 3 Add to 100mL deionized water (concentration is 5mmol / L), stir and dissolve at room temperature, then add to the obtained AgNO 3 Add 0.05g of sodium citrate to the solution, and then add NaBH dropwise to the solution at a rate of 3 drops / second under constant temperature magnetic stirring at 20°C. 4 Solution, stop dripping until the solution turns yellowish brown, continue to stir and react for 6 hours; then centrifuge the reacted solution, wash the precipitate with ethanol and acetone twice, and dry it in vacuum at 35°C for 15h to obtain nano-silver; ×10 -3 Add nanometer silver into 15mL distilled water, ultrasonic 20 minutes, ob...

Embodiment 3

[0059] A kind of chitosan / gelatin / nano-silver conductive antibacterial biological material, the preparation method is as follows:

[0060] 1) Preparation of nano-silver dispersion: weigh 0.15g NaBH 4 Add to 40mL deionized water, sonicate at room temperature for 8 minutes to get NaBH 4 Solution (concentration is 0.1mol / L), standby; Weigh 0.15gAgNO 3 Add to 300mL deionized water (concentration is 3mmol / L), stir and dissolve at room temperature, then add to the obtained AgNO 3 Add 0.07g of sodium citrate to the solution, and then add NaBH dropwise to the solution at a rate of 4 drops / second under constant temperature magnetic stirring at 30°C. 4 Solution, stop dripping until the solution turns yellowish brown, continue to stir and react for 10 hours; then centrifuge the reacted solution, wash the precipitate with ethanol and acetone 4 times, and dry it in vacuum at 45°C for 8h to obtain nano-silver; 5.0 ×10 -2 Add 1 g of nano silver into 10 mL of distilled water, and ultrason...

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Abstract

The invention relates to a chitosan / gelatin / nano-silver conductive antibacterial biological material and a preparation method thereof. The steps of the preparation method are as follows: (1) prepare chitosan solution; (2) prepare electrodeposition solution; (3) prepare chitosan / gelatin / nano-silver conductive antibacterial biomaterial: use titanium alloy sheet as cathode, platinum sheet as The anode is immersed in the electrodeposition solution prepared in step (2). After the electrodeposition is completed, the titanium alloy sheet with the deposition layer is taken out for cleaning, and then immersed in 1-ethyl-3-[3- In the aqueous solution of dimethylaminopropyl] carbodiimide hydrochloride, the reaction is completed and post-processed to obtain the chitosan / gelatin / nano-silver conductive antibacterial biological material. The preparation method of the invention has the characteristics of simple operation, easy control, simple equipment, mild reaction conditions, etc., and the prepared material has good biocompatibility and biodegradability, and has electrical conductivity and excellent antibacterial activity.

Description

technical field [0001] The invention relates to the preparation of biological materials, in particular to a chitosan / gelatin / nano-silver conductive antibacterial biological material and a preparation method thereof. Background technique [0002] Electrodeposition technology provides a new method for constructing functional film materials on the surface of conductive materials, which has potential application value in many technical fields [Soft matter, 2013, 9(9): 2703-2710]. Compared with the traditional technology, the electrodeposition technology is simple and easy to operate, and the preparation conditions are mild, and the performance of the deposited film can be adjusted by changing the deposition voltage, deposition time, deposition solution concentration, etc., and has time and space selectivity. Chitosan is the deacetylation product of chitin, which has good biocompatibility and biodegradability, and is widely used in the field of biomedicine. In addition, chitosan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D15/00B82Y40/00
Inventor 王艺峰郭雪成潘瑞浩韩笛陈涛郭萌萌耿增华
Owner WUHAN UNIV OF TECH
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