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Preparation method of cyclodextrin inclusion compound liposome with whitening effect

A whitening effect, cyclodextrin technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as difficulty in wide use and affecting product color, and achieve improved stability, high water solubility, and convenient use Effect

Active Publication Date: 2015-01-28
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the daisy flower extract is exposed to the air, it is easy to change from light yellow to dark brown, which affects the color tone of the final product
Although the daisy flower extract has good whitening effect, it is difficult to widely use it in whitening cosmetics due to the problem of discoloration

Method used

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  • Preparation method of cyclodextrin inclusion compound liposome with whitening effect
  • Preparation method of cyclodextrin inclusion compound liposome with whitening effect
  • Preparation method of cyclodextrin inclusion compound liposome with whitening effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method of cyclodextrin inclusion compound liposome with whitening effect, adopts the following steps:

[0047] A: Weigh 1g of Haematococcus pluvialis extract, 3g of Laminaria cuneiformis extract and 10g of hydroxypropyl-β-cyclodextrin according to the mass ratio of 1:3:10;

[0048] B: Mix the Haematococcus pluvialis extract and the kelp kelp extract weighed in step A, pour the resulting mixture into analytical pure ethanol and stir and dissolve to obtain an ethanol solution. The mass ratio of the mixture to ethanol is 1:5;

[0049] C: Add the hydroxypropyl-β-cyclodextrin weighed in step A into deionized water, stir slowly at room temperature until dissolved to obtain an aqueous cyclodextrin solution, and the hydroxypropyl-β-cyclodextrin The mass ratio with deionized water is 1:10;

[0050] D: Mix the ethanol solution obtained in step B with the cyclodextrin aqueous solution obtained in step C, stir evenly and let stand for 1 hour, centrifuge for 30 minut...

Embodiment 2

[0056] A preparation method of cyclodextrin inclusion compound liposome with whitening effect, adopts the following steps:

[0057] A: Weigh 1g of Haematococcus pluvialis extract, 5g of Laminaria kelp extract and 15g of hydroxypropyl-β-cyclodextrin according to the mass ratio of 1:5:15;

[0058] B: Mix the Haematococcus pluvialis extract and the kelp kelp extract weighed in step A, pour the resulting mixture into analytical pure ethanol and stir and dissolve to obtain an ethanol solution. The mass ratio of the mixture to ethanol is 1:5;

[0059] C: Add the hydroxypropyl-β-cyclodextrin weighed in step A into deionized water, stir slowly at room temperature until dissolved to obtain an aqueous cyclodextrin solution, and the hydroxypropyl-β-cyclodextrin The mass ratio with deionized water is 1:10;

[0060] D: Mix the ethanol solution obtained in step B with the cyclodextrin aqueous solution obtained in step C, stir evenly and let stand for 1 hour, centrifuge for 30 minutes at a...

Embodiment 3

[0066] A preparation method of cyclodextrin inclusion compound liposome with whitening effect, adopts the following steps:

[0067] A: Weigh 1g Haematococcus pluvialis extract, 4g Laminaria kelp extract and 12g hydroxypropyl-β-cyclodextrin according to the mass ratio of 1:4:12;

[0068] B: Mix the Haematococcus pluvialis extract and the kelp kelp extract weighed in step A, pour the resulting mixture into analytical pure ethanol and stir and dissolve to obtain an ethanol solution. The mass ratio of the mixture to ethanol is 1:5;

[0069] C: Add the hydroxypropyl-β-cyclodextrin weighed in step A into deionized water, stir slowly at room temperature until dissolved to obtain an aqueous cyclodextrin solution, and the hydroxypropyl-β-cyclodextrin The mass ratio with deionized water is 1:10;

[0070] D: Mix the ethanol solution obtained in step B with the cyclodextrin aqueous solution obtained in step C, stir evenly and let stand for 1 hour, centrifuge for 30 minutes at a speed of...

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Abstract

The invention relates to a preparation method of a cyclodextrin inclusion compound liposome with a whitening effect. The method comprises the following steps: A, weighing extract of haematococcus pluvialis and extract of laminaria ochroleuca to prepare an ethanol solution; B, weighing hydroxypropyl-beta-cyclodextrin to prepare an aqueous solution of cyclodextrin; C, uniformly mixing the ethanol solution and the aqueous solution of cyclodextrin, centrifuging to filter out precipitates and carrying out liquid drying to obtain a cyclodextrin inclusion compound; D, weighing hydrogenated polydecene, hydrogenated lecithin and sucrose dilaurate, mixing and heating to obtain a liquid oil phase; E, weighing the cyclodextrin inclusion compound, palmaria palmata extract, pancratium zeylanicum extract, daisy extract and deionized water, mixing and heating to obtain a liquid water phase; F, adding the liquid oil phase into the liquid water phase to carry out homogenizing so as to obtain liposome suspension; G, freezing and drying to obtain the cyclodextrin inclusion compound liposome with the whitening effect. According to the preparation method, various active matters can be simultaneously loaded; the technical defect of poor compatibility between various active matters is overcome; percutaneous permeability and slow-release property of the active matters are improved.

Description

Technical field [0001] The present invention involves the field of lipid system preparation of cyclical seizure compounds, and specially involves a preparation method of a whitening cymbal concentration compound liposuction. Background technique [0002] The wedge -based kelp (LAMINARIA Ochroleuca) extract, the manufacturer is the French Biotech Marine company, which is rich in bacteria -like amino acids. It can protect DNA from ultraviolet damage and reduce the aging and dark phenomenon caused by sunlight.The wedge -based kelp extract is oil -soluble, but the nature of its anti -ultraviolet ingredients is unstable, and it is exposed to the semi -half -half period below the indoor light. There are great problems in the application. [0003] Palmaria Palmata extract, the manufacturer is French Silab, rich in FLORIDOSIDE and isofloridoside, which can reduce the transit of keratinic cells to the skin pigmentation, thereby reducing skin pigmentation.EssenceThe palm leaf tree is used ...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/14A61K8/73A61Q19/02
Inventor 蒋丽刚毕永贤陈斌殷海琴陈玉燕刘丽仙张甜
Owner PROYA COSMETICS
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