Tablet containing grifola frondosa and preparation method thereof
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A technology of Grifola frondosa and Grifola frondosa polysaccharides, applied in the field of medicine, can solve the problems of not meeting the quality requirements of drugs, unqualified dissolution rate, fast moisture absorption of Grifola frondosa, etc., to ensure long-term stable storage, ensure consistency, improve The effect of formability and yield
Inactive Publication Date: 2015-02-25
CHENGDU YILUKANG MEDICAL TECH & SERVICE
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[0007] The purpose of the present invention is to overcome the technical defects of Grifola frondosa in the process of the prior art, such as fast moisture absorption, poor compressibility, unqualified dissolution rate during storage, and failure to meet the quality requirements of medicines, and provide a kind of ash frondosa with stable properties. The tree flower oral preparation provides a simple and controllable process for the preparation of this stable preparation, which is suitable for large-scale production
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Embodiment 1
[0033] Accurately weigh: Grifola frondosa polysaccharide 500g, crospovidone 40g, magnesium stearate 5g, gastric soluble coating premix 25g. Grifola frondosa polysaccharide and crospovidone are pulverized, passed through a 80-mesh sieve, mixed and dry-granulated to obtain granules; added magnesium stearate that has been weighed, and mixed; then, under the condition that the ambient humidity is less than 45%. The next steps are: tableting, coating, and subpackaging to obtain 1000 tablets of Grifola frondosa.
Embodiment 2
[0035] Accurately weigh: Grifola frondosa 500g, crospovidone 60g, magnesium stearate 5g, silicon dioxide 5g, gastric soluble coating premix 25g. Grifola frondosa polysaccharide, crospovidone and silicon dioxide were pulverized, passed through an 80-mesh sieve, mixed and dry-granulated to obtain granules; Under the condition of less than 45%, sequentially: tableting, coating, sub-packaging, 1000 tablets of Grifola frondosa tablets are obtained.
Embodiment 3
[0037] Accurately weigh: Grifola frondosa 500g, copovidone S63040g, crospovidone 60g, magnesium stearate 5g, silicon dioxide 5g, sodium stearyl fumarate 5g, gastric soluble coating premix 35g. Grifola frondosa polysaccharide, crospovidone, copovidone S630, silicon dioxide, and sodium stearyl fumarate were pulverized, passed through an 80-mesh sieve, mixed and dry-granulated to obtain granules; Magnesium fatty acid, mixed evenly; then, under the condition that the ambient humidity is less than 45%, sequentially: tableting, coating, and subpackaging to obtain 1000 tablets of Grifola frondosa.
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Abstract
The invention discloses a tablet containing grifola frondosa. The tablet mainly comprises the following components in parts by weight: 500 parts of grifola frondosa polysaccharide, 40-60 parts of crosslinked povidone, 10-30 parts of copovidone S630, 5-10 parts of silicon dioxide, 5-10 parts of a lubricating agent and 25-50 parts of a gastric soluble type coating premixing agent. According to the tablet disclosed by the invention, characteristics of raw material medicines are combined, and povidone series auxiliary materials which have good compatibility with the tablet are screened; and meanwhile, a tablet compression chamber is specially controlled, so that an unexpected effect can be achieved, and the forming performance and yield of tablet cores and the stability of the tablet cores in a storage period can be significantly improved; and the tablet is simple in overall process and high in finished product yield, is suitable for large-scale production, and has relatively large application values.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a tablet containing grifola frondosa and a preparation method thereof. Background technique [0002] Grifolafrondosa (Fr) S.F.Gray, also known as Chestnut Mushroom and Bayleaf Polypore, is called "Maitake" in Japan; it belongs to Basidiomycetes and Polyporaceae in taxonomy, and is a rare medicinal and edible species. Edible fungi. It is delicious in taste, rich in nutrition, and contains many active substances. Grifola frondosa polysaccharide is the most important type of active ingredient, which can be used as a biological response modifier (BRM). Grifola frondosa polysaccharides have a wide range of physiological activities such as enhancing immune function, inhibiting tumors, anti-HIV virus, stabilizing blood pressure, lowering blood sugar, and improving fat metabolism. [0003] The chemical components of Grifola frondosa are mainly isolated from the fruiting b...
Claims
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Application Information
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