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Medicinal adhesive and preparation method thereof

An adhesive and polyacrylate technology, applied in surgical adhesives, applications, medical science and other directions, can solve the problems of unstable molding products, unsatisfactory curing speed, and difficulty in controlling dosage, etc., to improve product stability and curing. Moderate speed, easy to add effects

Active Publication Date: 2015-02-25
美迪科(上海)包装材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing medical adhesives, due to the imperfect formula and generally use SO2 as a polymerization inhibitor, are difficult to control the dosage, making the molded product unstable, the curing speed is not ideal during use, and the adhesive strength is not enough. Moreover, during use Prone to albinism, highly irritating to the human body, causing a burning sensation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A medical adhesive, comprising in parts by weight: 3 parts of polyacrylate, 2 parts of tragacanth gum, 1 part of polymethacrylate, 2 parts of squalane, 3 parts of benzoyl peroxide, and glycerol trirosin 4 parts of acid esters, 2 parts of dimethyl sebacate, 1 part of hydroquinone, 3 parts of p-toluenesulfonic acid, 2 parts of dioctyl phthalate, 1 part of tricalcium phosphate, 3 parts of sodium alginate .

[0017] The preparation method of above-mentioned medical adhesive, comprises the following steps:

[0018] Step 1: Pour the polyacrylate, tragacanth, polymethacrylate and squalane into the stirring tank, the vacuum degree of the stirring tank is 0.08MPa, stir evenly, heat the stirring tank to 100°C, and then add the Benzoyl oxide and glyceryl triabietic acid ester, stir evenly, and cool to room temperature to obtain mixture I;

[0019] Step 2, pour dimethyl sebacate, hydroquinone, p-toluenesulfonic acid, dioctyl phthalate, tricalcium phosphate and sodium alginate int...

Embodiment 2

[0022] A medical adhesive, comprising in parts by weight: 4 parts of polyacrylate, 3 parts of tragacanth gum, 2 parts of polymethacrylate, 3 parts of squalane, 5 parts of benzoyl peroxide, and glycerol trirosin 6 parts of acid ester, 3 parts of dimethyl sebacate, 2 parts of hydroquinone, 5 parts of p-toluenesulfonic acid, 4 parts of dioctyl phthalate, 2 parts of tricalcium phosphate, 4 parts of sodium alginate .

[0023] The preparation method of above-mentioned medical adhesive, comprises the following steps:

[0024] Step 1: Pour the polyacrylate, tragacanth, polymethacrylate and squalane into the stirring tank, the vacuum degree of the stirring tank is 0.09MPa, stir evenly, heat the stirring tank to 110°C, and then add the Benzoyl oxide and glyceryl triabietic acid ester, stir evenly, and cool to room temperature to obtain mixture I;

[0025] Step 2, pour dimethyl sebacate, hydroquinone, p-toluenesulfonic acid, dioctyl phthalate, tricalcium phosphate and sodium alginate i...

Embodiment 3

[0028] A medical adhesive, comprising in parts by weight: 7 parts of polyacrylate, 5 parts of tragacanth gum, 4 parts of polymethacrylate, 5 parts of squalane, 9 parts of benzoyl peroxide, and glycerol trirosin 7 parts of acid ester, 6 parts of dimethyl sebacate, 4 parts of hydroquinone, 7 parts of p-toluenesulfonic acid, 6 parts of dioctyl phthalate, 3 parts of tricalcium phosphate, 7 parts of sodium alginate .

[0029] The preparation method of above-mentioned medical adhesive, comprises the following steps:

[0030] Step 1: Pour the polyacrylate, tragacanth, polymethacrylate and squalane into the stirring tank, the vacuum degree of the stirring tank is 0.1MPa, stir evenly, heat the stirring tank to 100°C, and then add the Benzoyl oxide and glyceryl triabietic acid ester, stir evenly, and cool to room temperature to obtain mixture I;

[0031] Step 2, pour dimethyl sebacate, hydroquinone, p-toluenesulfonic acid, dioctyl phthalate, tricalcium phosphate and sodium alginate in...

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Abstract

The invention provides a medicinal adhesive and a preparation method thereof. The medicinal adhesive comprises polyacrylate, tragacanth, polymethacrylate, squalane, benzoyl peroxide, rosin triglyceride, dimethyl sebacate, p-dihydroxybenzene, p-benzene methane sulfonic acid, dioctyl phthalate, tricalcium phosphate and sodium alginate. The preparation method of the medicinal adhesive comprises the following steps: firstly mixing polyacrylate, tragacanth, polymethacrylate and squalane, then adding benzoyl peroxide and rosin triglyceride, and stirring to obtain a mixture I; then mixing dimethyl sebacate, p-dihydroxybenzene, p-benzene methane sulfonic acid, dioctyl phthalate, tricalcium phosphate and sodium alginate to obtain a mixture II, and then mixing the mixture I and the mixture II, heating, insulating, and cooling to room temperature, so that the medicinal adhesive is obtained. The medicinal adhesive has the advantages of moderate curing speed, long stabilization time and strong bonding strength.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and particularly relates to a medical adhesive and a preparation method thereof. Background technique [0002] The use of medical adhesives dates back centuries. At first, animal glue was obtained from animal skin, tendon and cartilage. The ancient Romans first used a mixture called medicinal adhesives in Egypt around 3000 BC, and later the ancient Greeks prepared a medicinal plaster-like mixture from olive oil, lead oxide and water. In 1845, one of the first patents was granted for a natural rubber pressure-sensitive adhesive for use as a surgical adhesive tape. In 1936, the German Kulzeer Co company sold dental adhesives with methyl methacrylate (MMA) as the main body. In 1959, the United States Eastman910 fast adhesive (α-methyl cyanoacrylate) came out, realizing the great revolution of surgical operation from sewing, tying to bonding. In 1960, Charnly first successfully ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/18A61L15/58
CPCA61L24/00A61L24/02A61L24/06A61L24/08C08L5/04C08L5/00C08L33/08C08L33/10
Inventor 郭玉芹李永超刘乐峰
Owner 美迪科(上海)包装材料有限公司
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