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Online rapid detection method of herba andrographis concentrated decolorization process

A detection method and technology of Andrographis paniculata, applied in the field of process analysis, can solve problems such as unreported, and achieve the effects of stable product quality, easy operation, and good model prediction ability.

Active Publication Date: 2015-03-04
ZHEJIANG UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

At present, the quality control in the key process of traditional Chinese medicine production is applied to the research of online ultraviolet technology. There are some literature patents, such as patents (patent application number: 201320490161.4, 201310350212.8), etc. The research is on the rapid detection of online ultraviolet in the extraction process of traditional Chinese medicine. , the literature has reports such as "Rapid Analysis Technology of Danhong Extract Quality Based on UV Spectrum-Yan Binjun", but there is no report on the use of online UV for the concentration and decolorization of Andrographis paniculata.

Method used

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  • Online rapid detection method of herba andrographis concentrated decolorization process

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Experimental program
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Effect test

Embodiment 1

[0027] 1. Install an online UV detection device

[0028] see figure 1 , the online ultraviolet detection device is composed of the following parts: the online ultraviolet detection system mainly includes a heating device 1, a reaction kettle 2, a peristaltic pump 3, a filter 4, a sampling port 5, a flow cell 6, an ultraviolet-visible light source 7, an online Ultraviolet spectrometer 8, workbench 9, circulation pipeline 10, cooling pump 11, distillate receiving bottle 12, reaction kettle 2 is connected to peristaltic pump 3, filter 4, sampling port 5, flow cell 6 through circulation pipeline 10 to form a loop , the ultraviolet-visible light source 7, the flow cell 6, the online ultraviolet spectrometer 8, and the workbench 9 are connected in series. One end of the cooling pump 11 is connected to the reaction kettle 2, and the other end is connected to the distillate receiving bottle 12.

[0029] The solution in the reaction kettle 2 is introduced into the circulation pipeline...

Embodiment 2

[0045] According to the method of Example 1, the difference lies in the establishment of a quantitative calibration model for dehydroandrographolide.

[0046] 1. Select the same sample data as in Example 1

[0047] Among the 9 batches of experimental data, batch 5 is taken as the verification set, and the remaining batches participate in the establishment of the calibration model. Before modeling, the abnormal spectrum and the measured data are discriminated, and the abnormal points are eliminated to improve the performance of the model.

[0048] 2. Establishment of a Quantitative Calibration Model for Dehydroandrographolide

[0049] The partial least square method of TQ Analyst software was used to establish a quantitative model for the content of dehydroandrographolide, and the collected spectral data was correlated with the lactone content measured by high performance liquid chromatography. After calculation and processing by TQ software, dehydroandrographolide is modeled...

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Abstract

The invention provides an online rapid detection method of a herba andrographis concentrated decolorization process. An online UV detection device is installed, a concentrated solution sample and a corresponding online UV spectrum are collected, the content of a quality control index in a sample solution is detected by using a high performance liquid chromatography and a partial least squares method is used for establishing a quantitative calibration model and the test is implemented. The model established by the invention has good calibration and prediction abilities, and has the advantages that the contents of andrographolide and dehydroandrographolide in the herba andrographis extract concentrated decolorization process can be detected more quickly and accurately compared with the traditional analysis method; the detection method is favorable for improving the quality control level of traditional Chinese medicine products in the production process, and the stability and the reliability of product quality are ensured.

Description

technical field [0001] The invention belongs to the technical field of process analysis, and in particular relates to an on-line ultraviolet spectrum rapid detection method in the concentration and decolorization process of Andrographis paniculata paniculata. Background technique [0002] The process of concentration and decolorization of Andrographis paniculata extract is one of the main production processes of Andrographis paniculata Chinese patent medicine, which is closely related to the efficacy and quality stability of the patent medicine. In industrial production, the medicinal material of Andrographis paniculata is extracted with 95% ethanol to obtain the extract, which is concentrated by heating and decolorized by adding medicinal activated carbon. Andrographolide and dehydroandrographolide are the main components in this process. Because the content of active ingredients in different parts of Andrographis paniculata is different, the initial concentration of each ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33G01N30/02
Inventor 金叶陈佳善刘雪松吴永江陈勇
Owner ZHEJIANG UNIV
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